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Peer-reviewedCC BY-NC 3.0Chemical Science

Counterion modulation of aza-BODIPY aggregation behaviour for boosted sonodynamic therapy

  • You Dou1,2
  • Guoyan Fang3
  • Junhua Zhang2
  • Yuting Wang4
  • Yuntao Li1
  • Sheng Qiu1
  • Jun Li5
  • Yao Sun4,6
  • Junrong Li2
6 affiliations
  1. 1Department of Neurosurgery, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University (Huzhou Central Hospital), Huzhou Key Laboratory of Basic Research and Clinical Translation for Neuromodulation Huzhou 313099 China
  2. 2College of Chemistry, Central China Normal University Wuhan 430079 China
  3. 3Clinical Laboratory, Wuhan Jinyintan Hospital Wuhan 430070 China
  4. 4National Key Laboratory of Agricultural Microbiology, College of Biomedicine and Health, Huazhong Agricultural University Wuhan 430070 China
  5. 5College of Chemistry, Huazhong Agricultural University Wuhan 430070 China
  6. 6Hubei Jiangxia Laboratory Wuhan 430020 China
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Abstract

Small-molecule based sonosensitizers hold great promise for deep-seated tumor therapy, yet their structure–activity relationships (SARs) remained largely unexplored, hindering their further biomedical applications. Herein, we propose a counterion-engineering strategy to modulate the aggregation behaviour of aza-BODIPY dyes, thereby achieving high-performance sonodynamic therapy (SDT). We demonstrated that Cl−-paired aza-BODIPY dye (BT-Cl) formed nanoparticles with the smallest hydrodynamic diameter and yielded the highest levels of reactive oxygen species (ROS). BT-Cl NPs also displayed potent sonodynamic cytotoxicity toward both 4T1 and U87-MG cells. Consequently, BT-Cl exhibited excellent tumor growth inhibition with minimal side effects. Overall, this work underscored the critical role of noncovalent ion-pairing interactions in governing small-molecule sonosensitizer aggregation and provided a facile approach for the rational design of high-efficiency sonosensitizers.

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Cite

BibTeXRIS
BibTeX
@article{dou2026counterion,
  title = {{Counterion modulation of aza-BODIPY aggregation behaviour for boosted sonodynamic therapy}},
  author = {You Dou and Guoyan Fang and Junhua Zhang and Yuting Wang and Yuntao Li and Sheng Qiu and Jun Li and Yao Sun and Junrong Li},
  journal = {Chemical Science},
  year = {2026},
  month = sep,
  doi = {10.1039/d6sc05519b},
  url = {https://doi.org/10.1039/d6sc05519b},
  note = {CC BY-NC 3.0},
}
RIS
TY  - JOUR
TI  - Counterion modulation of aza-BODIPY aggregation behaviour for boosted sonodynamic therapy
AU  - You Dou
AU  - Guoyan Fang
AU  - Junhua Zhang
AU  - Yuting Wang
AU  - Yuntao Li
AU  - Sheng Qiu
AU  - Jun Li
AU  - Yao Sun
AU  - Junrong Li
PY  - 2026
DA  - 2026/09/01
JO  - Chemical Science
DO  - 10.1039/d6sc05519b
UR  - https://doi.org/10.1039/d6sc05519b
AB  - Small-molecule based sonosensitizers hold great promise for deep-seated tumor therapy, yet their structure–activity relationships (SARs) remained largely unexplored, hindering their further biomedical applications. Herein, we propose a counterion-engineering strategy to modulate the aggregation behaviour of aza-BODIPY dyes, thereby achieving high-performance sonodynamic therapy (SDT). We demonstrated that Cl−-paired aza-BODIPY dye (BT-Cl) formed nanoparticles with the smallest hydrodynamic diameter and yielded the highest levels of reactive oxygen species (ROS). BT-Cl NPs also displayed potent sonodynamic cytotoxicity toward both 4T1 and U87-MG cells. Consequently, BT-Cl exhibited excellent tumor growth inhibition with minimal side effects. Overall, this work underscored the critical role of noncovalent ion-pairing interactions in governing small-molecule sonosensitizer aggregation and provided a facile approach for the rational design of high-efficiency sonosensitizers.
SN  - 2041-6520
SN  - 2041-6539
ER  -