Non-haematologic alloimmune manifestations following paediatric haematopoietic stem cell transplantation: a case series.
- 1Department of Paediatric Haematology and Bone Marrow Transplant, Manchester University NHS Foundation Trust, Manchester, UK. [email protected].
- 2Department of Paediatric Haematology and Bone Marrow Transplant, Manchester University NHS Foundation Trust, Manchester, UK.
Abstract
Non-haematological alloimmune manifestations following haematopoeitic stem cell transplant are rare, but contribute to significant morbidity and mortality in paediatric transplant recipients. Current literature is limited to case reports of individual patients. Often, diagnosis can be challenging and conditions require multiple lines of therapy. We describe three unique cases of non-haematological alloimmune manifestations from a single centre in the UK, which demonstrates the breadth of alloimmunity in paediatric transplant patients from isolated single organ disease, to widespread systemic alloimmune disease necessitating second haematopoietic stem cell transplant. Early consideration of such manifestations is essential to facilitate appropriate diagnosis and initiation of targeted therapies to improve patient outcomes.
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BibTeX
@article{cahill2026nonhaematologic,
title = {{Non-haematologic alloimmune manifestations following paediatric haematopoietic stem cell transplantation: a case series.}},
author = {Hilary Cahill and Ramya Hanasoge-Nataraj and Oana Mirci-Danicar and Omima Mustafa and Robert F Wynn and Srividhya Senthil},
journal = {Annals of hematology},
year = {2026},
month = sep,
doi = {10.1007/s00277-026-07252-1},
url = {https://europepmc.org/article/MED/42911405},
note = {CC BY},
}
RIS
TY - JOUR
TI - Non-haematologic alloimmune manifestations following paediatric haematopoietic stem cell transplantation: a case series.
AU - Hilary Cahill
AU - Ramya Hanasoge-Nataraj
AU - Oana Mirci-Danicar
AU - Omima Mustafa
AU - Robert F Wynn
AU - Srividhya Senthil
PY - 2026
DA - 2026/09/01
JO - Annals of hematology
DO - 10.1007/s00277-026-07252-1
UR - https://europepmc.org/article/MED/42911405
AB - Non-haematological alloimmune manifestations following haematopoeitic stem cell transplant are rare, but contribute to significant morbidity and mortality in paediatric transplant recipients. Current literature is limited to case reports of individual patients. Often, diagnosis can be challenging and conditions require multiple lines of therapy. We describe three unique cases of non-haematological alloimmune manifestations from a single centre in the UK, which demonstrates the breadth of alloimmunity in paediatric transplant patients from isolated single organ disease, to widespread systemic alloimmune disease necessitating second haematopoietic stem cell transplant. Early consideration of such manifestations is essential to facilitate appropriate diagnosis and initiation of targeted therapies to improve patient outcomes.
SN - 0939-5555
SN - 1432-0584
ER -