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Peer-reviewedCC BYEJHaem

Recurrent Steroid-Responsive Epiglottitis Following Cord Blood Transplantation: A Case Report.

  • Ryo Nakagawa1
  • Koichi Onodera1
  • Hikaru Kon1
  • Mizuki Watanabe1
  • Hiroaki Abe1
  • Eiji Ogawa1
  • Hikaru Kumagai1
  • Toaki Maeda1
  • Akihisa Kawajiri1
  • Shunsuke Hatta1
  • Risako Kakuta2
  • Noriko Fukuhara1
1 more authors
  • Hideo Harigae1
  1. 1Department of Hematology Tohoku University Hospital Sendai Miyagi Japan.
  2. 2Department of Otolaryngology, Head and Neck Surgery Tohoku University Hospital Sendai Miyagi Japan.
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Abstract

Epiglottitis is an acute inflammation of the epiglottis, typically caused by bacterial infections and potentially life-threatening due to rapid airway obstruction. There are extremely rare case reports of epiglottitis as a complication following allogeneic stem cell transplantation (allo-SCT). We report a 56-year-old female case with adult T-cell lymphoma (ATL) who suffered from recurrent epiglottitis after cord blood transplantation (CBT). Her epiglottitis was refractory to empirical antibiotic therapy. However, it responded promptly to corticosteroids, preventing the development of severe respiratory failure. This report implicated the importance of recognizing non-infectious epiglottic inflammation in the setting of transplantation and cellular therapy. Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.

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Cite

BibTeXRIS
BibTeX
@article{nakagawa2026recurrent,
  title = {{Recurrent Steroid-Responsive Epiglottitis Following Cord Blood Transplantation: A Case Report.}},
  author = {Ryo Nakagawa and Koichi Onodera and Hikaru Kon and Mizuki Watanabe and Hiroaki Abe and Eiji Ogawa and Hikaru Kumagai and Toaki Maeda and Akihisa Kawajiri and Shunsuke Hatta and Risako Kakuta and Noriko Fukuhara and Hideo Harigae},
  journal = {EJHaem},
  year = {2026},
  month = oct,
  doi = {10.1002/jha2.70441},
  url = {https://europepmc.org/article/MED/42910346},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Recurrent Steroid-Responsive Epiglottitis Following Cord Blood Transplantation: A Case Report.
AU  - Ryo Nakagawa
AU  - Koichi Onodera
AU  - Hikaru Kon
AU  - Mizuki Watanabe
AU  - Hiroaki Abe
AU  - Eiji Ogawa
AU  - Hikaru Kumagai
AU  - Toaki Maeda
AU  - Akihisa Kawajiri
AU  - Shunsuke Hatta
AU  - Risako Kakuta
AU  - Noriko Fukuhara
AU  - Hideo Harigae
PY  - 2026
DA  - 2026/10/21
JO  - EJHaem
DO  - 10.1002/jha2.70441
UR  - https://europepmc.org/article/MED/42910346
AB  - Epiglottitis is an acute inflammation of the epiglottis, typically caused by bacterial infections and potentially life-threatening due to rapid airway obstruction. There are extremely rare case reports of epiglottitis as a complication following allogeneic stem cell transplantation (allo-SCT). We report a 56-year-old female case with adult T-cell lymphoma (ATL) who suffered from recurrent epiglottitis after cord blood transplantation (CBT). Her epiglottitis was refractory to empirical antibiotic therapy. However, it responded promptly to corticosteroids, preventing the development of severe respiratory failure. This report implicated the importance of recognizing non-infectious epiglottic inflammation in the setting of transplantation and cellular therapy. Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.
SN  - 2688-6146
ER  -