The coefficient of variation of CT values for predicting lymph node metastasis in extrahepatic cholangiocarcinoma
- 1Department of Digestive and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan
- 2Department of Surgery, Keio University School of Medicine, Tokyo, Japan
Abstract
Preoperative prediction of lymph node metastasis (LNM) in extrahepatic cholangiocarcinoma (ECC) is crucial for surgical strategies and prognosis, as current imaging methods are insufficient. A total of 149 ECC patients who underwent curative resection were retrospectively analyzed. We measured the Coefficient of Variation (CV) of CT values, ADC of MRI, and SUVmax of PET/CT from multiple lymph nodes. Diagnostic performance for LNM prediction was evaluated using ROC curve analysis. The CV of CT values was the most powerful independent predictor of LNM. Its AUC (0.829) was superior to MRI ADC (0.666) and PET/CT SUVmax (0.701). The CV of CT values showed a sensitivity of 72.8%, specificity of 72.9%, and accuracy of 72.9%. In conclusion, The CV of CT values is a promising and effective parameter for preoperatively predicting LNM in ECC. This can potentially improve patient selection for neoadjuvant therapies and surgical planning.
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BibTeX
@article{chiba2026coefficient,
title = {{The coefficient of variation of CT values for predicting lymph node metastasis in extrahepatic cholangiocarcinoma}},
author = {Naokazu Chiba and Yuta Abe and Hirotaka Kojima and Ryota Suda and Masashi Nakagawa and Shigeto Ochiai and Takahiro Gunji and Toru Sano and Satoshi Tabuchi and Tetsuo Ishizaki and Shigeyuki Kawachi},
journal = {PLOS One},
year = {2026},
month = sep,
doi = {10.1371/journal.pone.0357578},
url = {https://doi.org/10.1371/journal.pone.0357578},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - The coefficient of variation of CT values for predicting lymph node metastasis in extrahepatic cholangiocarcinoma
AU - Naokazu Chiba
AU - Yuta Abe
AU - Hirotaka Kojima
AU - Ryota Suda
AU - Masashi Nakagawa
AU - Shigeto Ochiai
AU - Takahiro Gunji
AU - Toru Sano
AU - Satoshi Tabuchi
AU - Tetsuo Ishizaki
AU - Shigeyuki Kawachi
PY - 2026
DA - 2026/09/11
JO - PLOS One
DO - 10.1371/journal.pone.0357578
UR - https://doi.org/10.1371/journal.pone.0357578
AB - Preoperative prediction of lymph node metastasis (LNM) in extrahepatic cholangiocarcinoma (ECC) is crucial for surgical strategies and prognosis, as current imaging methods are insufficient. A total of 149 ECC patients who underwent curative resection were retrospectively analyzed. We measured the Coefficient of Variation (CV) of CT values, ADC of MRI, and SUVmax of PET/CT from multiple lymph nodes. Diagnostic performance for LNM prediction was evaluated using ROC curve analysis. The CV of CT values was the most powerful independent predictor of LNM. Its AUC (0.829) was superior to MRI ADC (0.666) and PET/CT SUVmax (0.701). The CV of CT values showed a sensitivity of 72.8%, specificity of 72.9%, and accuracy of 72.9%. In conclusion, The CV of CT values is a promising and effective parameter for preoperatively predicting LNM in ECC. This can potentially improve patient selection for neoadjuvant therapies and surgical planning.
SN - 1932-6203
ER -