Skip to content
DraconiticResearch
Search Sources API
203,948 studies31 sourcesUpdated 43 min ago
Peer-reviewedCC BY-NC 4.0International Journal of Women's Health

Plasma Cell Cheilitis vs Actinic Cheilitis: A Comparative Case Study of Lips Lesions Characteristics and Histopathological Features

  • Nadya Jeihan Riyani1
  • Nuri Fitriasari2
  • Nelly Nainggolan3
  • Dewi Zakiawati4
4 affiliations
  1. 1Oral Medicine Residency Program, Department of Oral Medicine, Faculty of Dentistry, Universitas Padjadjaran, Bandung, West Java, Indonesia
  2. 2Oral Health Polyclinic, Oral Medicine Division, Dr. Hasan Sadikin Central General Hospital, Bandung, West Java, Indonesia
  3. 3Oral Health Polyclinic, Oral Medicine Division, Harapan Bunda Hospital, Bandar Jaya, Lampung, Indonesia
  4. 4Department of Oral Medicine, Faculty of Dentistry, Universitas Padjadjaran, Bandung, West Java, Indonesia
Read full textPDFDOICite

Abstract

Background: Plasma cell cheilitis (PCC) and actinic cheilitis (AC) represent two clinically distinct lip disorders that share overlapping features, posing diagnostic challenges for clinicians. PCC is a rare inflammatory condition characterized by erythematous plaques or ulcerations with dense dermal plasma cell infiltrates, while AC manifests as chronic sun-induced lip changes with potential malignant transformation. Despite affecting similar clinical features and risk factor, these conditions differ fundamentally in histopathological findings.

Purpose: This comparative case study analyzes the diagnostic complexities of PCC and AC.

Case Report: Case 1: A 60-year-old female came to the Oral Medicine Department with persistent lip erosion that had not healed for a year, reporting pain and bleeding. Clinical features and sun-exposure-related occupation suggested actinic cheilitis. Case 2: A 37-year-old woman came to the Oral Medicine Department presented with a recurring erosive lesion on her lower lip persisting for eight years, characterized by pain, dryness, and a thickened white border, and suspected as ulcerative oral lichen planus with actinic cheilitis and recurrent herpes labialis as differential diagnosis.

Case Management: Case 1: Incisional biopsy showed an ulcerated, fibrocollagenous connective tissue stroma, lymphoplasmacytic infiltration, and inflammatory cells with no malignant signs. Case 2: The patient’s biopsy revealed mild-to-moderate dysplasia alongside thickened skin layers and inflammation involving immune cells. Both cases were treated with topical corticosteroids and antibiotics, yielding significant improvement.

Conclusions: This comparative case report highlights the diagnostic complexities of PCC and AC through their parallel clinical presentations, emphasizing that lesion morphology and histopathological examination are essential in guiding accurate diagnosis and appropriate management. Long-term follow-up is warranted for both conditions, given the malignant transformation potential of AC and the recurrence tendency of PCC.

Related

  1. Comparative histopathological and immunohistochemical features of central nervous system and pulmonary tuberculosis: an exploratory retrospective study.
    Kaili Su, Junjun Liu, Runrui Wu +7
    Frontiers in cellular and infection microbiologyPeer-reviewedCC BYFull textSurgery & anaesthesiaEurope PMC
  2. Calcimimetic therapy modified the radiological, surgical, and histopathological features of a parathyroid adenoma
    JCEM case reportsPeer-reviewedCC BY-NC-NDFull textEndocrinology & metabolismEurope PMC
  3. Dermoscopic and Histopathological Features of Nonfamilial Multiple Trichoepitheliomas: A Case Report
    Lalla Safia Echarif, Maryem Aboudourib, Abdeljalil Ouaaziz +2
    CureusPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  4. Histopathological and virus-associated features of Boid Inclusion Body Disease in Boa constrictor
    M. Bogner, E. Dervas, S. De Neck +4
    bioRxivPreprintAll rights reservedFull textGeneral medicinebioRxiv
  5. Meta-analysis of the histopathological features of surgically removed aortas classified according to the SCVP and AECVP consensus documents
    Eemeli Jämsen, David Kalfeřt, Tero Halmesmäki +3
    American heart journal plus : cardiology research and practicePeer-reviewedCC BYFull textCardiovascular medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{riyani2026plasma,
  title = {{Plasma Cell Cheilitis vs Actinic Cheilitis: A Comparative Case Study of Lips Lesions Characteristics and Histopathological Features}},
  author = {Nadya Jeihan Riyani and Nuri Fitriasari and Nelly Nainggolan and Dewi Zakiawati},
  journal = {International Journal of Women's Health},
  year = {2026},
  month = oct,
  doi = {10.2147/ijwh.s631974},
  url = {https://doi.org/10.2147/ijwh.s631974},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Plasma Cell Cheilitis vs Actinic Cheilitis: A Comparative Case Study of Lips Lesions Characteristics and Histopathological Features
AU  - Nadya Jeihan Riyani
AU  - Nuri Fitriasari
AU  - Nelly Nainggolan
AU  - Dewi Zakiawati
PY  - 2026
DA  - 2026/10/30
JO  - International Journal of Women's Health
DO  - 10.2147/ijwh.s631974
UR  - https://doi.org/10.2147/ijwh.s631974
AB  - Background: Plasma cell cheilitis (PCC) and actinic cheilitis (AC) represent two clinically distinct lip disorders that share overlapping features, posing diagnostic challenges for clinicians. PCC is a rare inflammatory condition characterized by erythematous plaques or ulcerations with dense dermal plasma cell infiltrates, while AC manifests as chronic sun-induced lip changes with potential malignant transformation. Despite affecting similar clinical features and risk factor, these conditions differ fundamentally in histopathological findings.  Purpose: This comparative case study analyzes the diagnostic complexities of PCC and AC.  Case Report: Case 1: A 60-year-old female came to the Oral Medicine Department with persistent lip erosion that had not healed for a year, reporting pain and bleeding. Clinical features and sun-exposure-related occupation suggested actinic cheilitis. Case 2: A 37-year-old woman came to the Oral Medicine Department presented with a recurring erosive lesion on her lower lip persisting for eight years, characterized by pain, dryness, and a thickened white border, and suspected as ulcerative oral lichen planus with actinic cheilitis and recurrent herpes labialis as differential diagnosis.  Case Management: Case 1: Incisional biopsy showed an ulcerated, fibrocollagenous connective tissue stroma, lymphoplasmacytic infiltration, and inflammatory cells with no malignant signs. Case 2: The patient’s biopsy revealed mild-to-moderate dysplasia alongside thickened skin layers and inflammation involving immune cells. Both cases were treated with topical corticosteroids and antibiotics, yielding significant improvement.  Conclusions: This comparative case report highlights the diagnostic complexities of PCC and AC through their parallel clinical presentations, emphasizing that lesion morphology and histopathological examination are essential in guiding accurate diagnosis and appropriate management. Long-term follow-up is warranted for both conditions, given the malignant transformation potential of AC and the recurrence tendency of PCC.
SN  - 1179-1411
ER  -