Associations of Lifestyle‐Related Factors and Psoriatic Arthritis Disease Activity: The Dutch South West Psoriatic Arthritis Study
10 affiliations
- 1Erasmus Medical Center Rotterdam South Holland the Netherlands
- 2Albert Schweitzer Hospital Dordrecht South Holland the Netherlands
- 3Maasstad Hospital Rotterdam South Holland the Netherlands
- 4Haga Hospital the Hague South Holland the Netherlands
- 5Amphia Hospital Breda North Brabant the Netherlands
- 6Reumazorg Zuid West Nederland Roosendaal North Brabant the Netherlands
- 7Frisius Medical Center Leeuwarden Friesland the Netherlands
- 8Admiraal De Ruyter Hospital Goes Zeeland the Netherlands
- 9Reinier de Graaf Hospital Delft South Holland the Netherlands
- 10Franciscus Gasthuis and Vlietland Rotterdam South Holland the Netherlands
Abstract
Objective: This study aims to investigate lifestyle‐related factors in patients with psoriatic arthritis (PsA) and their association with disease activity measurements.
Methods: This multicenter cohort included 938 patients who were newly diagnosed with PsA between 2013 and 2023. A composite lifestyle risk score (range 0 to 5) was calculated using five lifestyle‐related factors assessed at baseline (body mass index, waist circumference, smoking, alcohol consumption, physical activity). Higher scores indicate the presence of more lifestyle‐related risk factors. One‐year disease activity outcomes included PsA Disease Activity Score (PASDAS), disease activity in PsA (DAPSA), PASDAS and DAPSA low disease activity (LDA) and remission, and minimal disease activity (MDA).
Results: The rate of obesity was 33%, abdominal obesity was 51%, current smoking was 19%, and alcohol consumption was 72%, with 3% of patients physically inactive. Using multivariable analyses, a higher lifestyle risk score was associated with higher PASDAS (β 0.15; 95% confidence interval [CI] 0.08–0.23), and lower odds for achieving PASDAS‐LDA (odds ratio [OR] 0.59; 95% CI 0.45–0.77), and MDA (OR 0.72; 95% CI 0.57–0.90) at one‐year follow‐up. Similar associations were observed for DAPSA (β 1.18; 95% CI 0.65–1.71) and DAPSA‐LDA (OR 0.74; 95% CI 0.59–0.92). Analysis of individual factors showed that general obesity, abdominal obesity, and smoking were significantly associated with higher PASDAS and DAPSA and lower odds for achieving PASDAS‐LDA and MDA.
Conclusion: Lifestyle‐related risk factors were prevalent in patients with PsA. The associations among lifestyle‐related factors and PsA disease activity, mainly obesity and smoking, provide a foundation to address lifestyle in PsA care.
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BibTeX
@article{hojeij2026associations,
title = {{Associations of Lifestyle‐Related Factors and Psoriatic Arthritis Disease Activity: The Dutch South West Psoriatic Arthritis Study}},
author = {Batoul Hojeij and Ilja Tchetverikov and Marc R. Kok and Marijn Vis and Yvonne Goekoop‐Ruiterman and Jessica Bijsterbosch and Paul Baudoin and Reinhard Bos and Jos H. van der Kaap and Petra Kok and Lindy‐Anne Korswagen and Jolanda J. Luime},
journal = {Arthritis Care \& Research},
year = {2026},
month = may,
doi = {10.1002/acr.80080},
url = {https://doi.org/10.1002/acr.80080},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Associations of Lifestyle‐Related Factors and Psoriatic Arthritis Disease Activity: The Dutch South West Psoriatic Arthritis Study
AU - Batoul Hojeij
AU - Ilja Tchetverikov
AU - Marc R. Kok
AU - Marijn Vis
AU - Yvonne Goekoop‐Ruiterman
AU - Jessica Bijsterbosch
AU - Paul Baudoin
AU - Reinhard Bos
AU - Jos H. van der Kaap
AU - Petra Kok
AU - Lindy‐Anne Korswagen
AU - Jolanda J. Luime
PY - 2026
DA - 2026/05/16
JO - Arthritis Care & Research
DO - 10.1002/acr.80080
UR - https://doi.org/10.1002/acr.80080
AB - Objective: This study aims to investigate lifestyle‐related factors in patients with psoriatic arthritis (PsA) and their association with disease activity measurements. Methods: This multicenter cohort included 938 patients who were newly diagnosed with PsA between 2013 and 2023. A composite lifestyle risk score (range 0 to 5) was calculated using five lifestyle‐related factors assessed at baseline (body mass index, waist circumference, smoking, alcohol consumption, physical activity). Higher scores indicate the presence of more lifestyle‐related risk factors. One‐year disease activity outcomes included PsA Disease Activity Score (PASDAS), disease activity in PsA (DAPSA), PASDAS and DAPSA low disease activity (LDA) and remission, and minimal disease activity (MDA). Results: The rate of obesity was 33%, abdominal obesity was 51%, current smoking was 19%, and alcohol consumption was 72%, with 3% of patients physically inactive. Using multivariable analyses, a higher lifestyle risk score was associated with higher PASDAS (β 0.15; 95% confidence interval [CI] 0.08–0.23), and lower odds for achieving PASDAS‐LDA (odds ratio [OR] 0.59; 95% CI 0.45–0.77), and MDA (OR 0.72; 95% CI 0.57–0.90) at one‐year follow‐up. Similar associations were observed for DAPSA (β 1.18; 95% CI 0.65–1.71) and DAPSA‐LDA (OR 0.74; 95% CI 0.59–0.92). Analysis of individual factors showed that general obesity, abdominal obesity, and smoking were significantly associated with higher PASDAS and DAPSA and lower odds for achieving PASDAS‐LDA and MDA. Conclusion: Lifestyle‐related risk factors were prevalent in patients with PsA. The associations among lifestyle‐related factors and PsA disease activity, mainly obesity and smoking, provide a foundation to address lifestyle in PsA care.
SN - 2151-464X
SN - 2151-4658
ER -