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Peer-reviewedCC BY-NC-ND 4.0ACS Omega

New Citrinin and Coumarin Derivatives from a Marine-Derived Penicillium sp. RCDB006

  • Qun Li1
  • Wu Ruan1
  • Yangrong Zhao2
  • Yihui Pan2
  • Lingbin Lin1
  • Wei Wu2
  • Wenjia Huang1
  • Xiaozhen Wang1
  • Guangli Deng1
  • Junfeng Wang2
  • Cai-Guang Yang2
  • Yi Chen2
1 more authors
  • Ming-Wei Wang1,3,4,5
5 affiliations
  1. 1Research Center for Deepsea Bioresources , ,
  2. 2Chinese Academy of Sciences , , ,
  3. 3Fudan University , , ,
  4. 4Shanghai Jiao Tong University School of Medicine , , ,
  5. 5Hainan Medical University , , ,
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Abstract

One new citrinin derivative (1) and four new coumarins (2–5), along with seven known compounds, were isolated from a deep-sea-derived fungus Penicillium sp. RCDB006 in the sediments of the Diamantina Fracture Zone, the second deepest trench in the Indian Ocean. Comprehensive spectroscopic analyses (NMR and HRESIMS) established the planar structures. Furthermore, the absolute configurations of compounds 1–5 were assigned by comparing experimental and calculated ECD data, alongside X-ray crystallographic analysis. These compounds were evaluated for antibacterial and antiproliferative activities against a panel of Gram-positive and Gram-negative bacteria, as well as two cancer cell lines. Compound 9 exhibited modest bactericidal activity and also inhibited the growth of human acute myeloid leukemia (MV4–11) and colorectal cancer (SW620) cells with IC50 values of 34.36 and 36.50 μM, respectively.

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Cite

BibTeXRIS
BibTeX
@article{li2026citrinin,
  title = {{New Citrinin and Coumarin Derivatives from a Marine-Derived Penicillium sp. RCDB006}},
  author = {Qun Li and Wu Ruan and Yangrong Zhao and Yihui Pan and Lingbin Lin and Wei Wu and Wenjia Huang and Xiaozhen Wang and Guangli Deng and Junfeng Wang and Cai-Guang Yang and Yi Chen and Ming-Wei Wang},
  journal = {ACS Omega},
  year = {2026},
  month = oct,
  doi = {10.1021/acsomega.6c05300},
  url = {https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c05300/5461062/New-Citrinin-and-Coumarin-Derivatives-from-a},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - New Citrinin and Coumarin Derivatives from a Marine-Derived Penicillium sp. RCDB006
AU  - Qun Li
AU  - Wu Ruan
AU  - Yangrong Zhao
AU  - Yihui Pan
AU  - Lingbin Lin
AU  - Wei Wu
AU  - Wenjia Huang
AU  - Xiaozhen Wang
AU  - Guangli Deng
AU  - Junfeng Wang
AU  - Cai-Guang Yang
AU  - Yi Chen
AU  - Ming-Wei Wang
PY  - 2026
DA  - 2026/10/29
JO  - ACS Omega
DO  - 10.1021/acsomega.6c05300
UR  - https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c05300/5461062/New-Citrinin-and-Coumarin-Derivatives-from-a
AB  - One new citrinin derivative (1) and four new coumarins (2–5), along with seven known compounds, were isolated from a deep-sea-derived fungus Penicillium sp. RCDB006 in the sediments of the Diamantina Fracture Zone, the second deepest trench in the Indian Ocean. Comprehensive spectroscopic analyses (NMR and HRESIMS) established the planar structures. Furthermore, the absolute configurations of compounds 1–5 were assigned by comparing experimental and calculated ECD data, alongside X-ray crystallographic analysis. These compounds were evaluated for antibacterial and antiproliferative activities against a panel of Gram-positive and Gram-negative bacteria, as well as two cancer cell lines. Compound 9 exhibited modest bactericidal activity and also inhibited the growth of human acute myeloid leukemia (MV4–11) and colorectal cancer (SW620) cells with IC50 values of 34.36 and 36.50 μM, respectively.
SN  - 2470-1343
ER  -