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PreprintCC BYChemRxiv

Earth-abundant 3d metal-catalyzed enantioselective catalysis towards the functionalization of E/Zalkenes mixtures.

  • Guillaume Delestras1
  • John Henry Reed2
  • Coralie Duchemin1
  1. 1Institut des Sciences Chimiques de Rennes (ISCR, UMR 6226), Univ. Rennes, CNRS, 263 Avenue du Général Leclerc, Rennes Cedex, 35042
  2. 2Process Chemistry R&D, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, Allschwil, Switzerland, CH-4123
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Abstract

Enantioselective catalysis transforming alkenes to chiral molecules have been a breakthrough in the field of organic synthesis. Though a major challenge persists. The “privileged” chiral catalyst capacities depend on the geometry of the olefin substrate which can be either E or Z. Enantioselective catalysis allowing to convert both alkene stereoisomers to a single chiral molecule promises sustainable synthetic routes and novel mechanistic strategies towards chiral molecule synthesis. Enantioselective methods towards the functionalization of E/Z-alkenes, which has largely taken advantages of the recent development of earth-abundant 3d metal catalysis, are covered in this revue. An emphasis on the mechanisms accounting for the observed stereoconvergence and enantioselectivity is proposed.

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Cite

BibTeXRIS
BibTeX
@misc{delestras2026earthabundant,
  title = {{Earth-abundant 3d metal-catalyzed enantioselective catalysis towards the functionalization of E/Zalkenes mixtures.}},
  author = {Guillaume Delestras and John Henry Reed and Coralie Duchemin},
  howpublished = {ChemRxiv},
  year = {2026},
  month = oct,
  doi = {10.26434/chemrxiv.15010148/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010148/v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Earth-abundant 3d metal-catalyzed enantioselective catalysis towards the functionalization of E/Zalkenes mixtures.
AU  - Guillaume Delestras
AU  - John Henry Reed
AU  - Coralie Duchemin
PY  - 2026
DA  - 2026/10/09
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15010148/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010148/v1
AB  - Enantioselective catalysis transforming alkenes to chiral molecules have been a breakthrough in the field of organic synthesis. Though a major challenge persists. The “privileged” chiral catalyst capacities depend on the geometry of the olefin substrate which can be either E or Z. Enantioselective catalysis allowing to convert both alkene stereoisomers to a single chiral molecule promises sustainable synthetic routes and novel mechanistic strategies towards chiral molecule synthesis. Enantioselective methods towards the functionalization of E/Z-alkenes, which has largely taken advantages of the recent development of earth-abundant 3d metal catalysis, are covered in this revue. An emphasis on the mechanisms accounting for the observed stereoconvergence and enantioselectivity is proposed.
ER  -