Cubosome integrated with polymeric carbon nitride and cisplatin: in vivo biodistribution and in vitro photodynamic therapy studies.
11 affiliations
- 1Department of Medical Research, Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, 40403, Taiwan.
- 2Department of Obstetrics and Gynecology, Asia University Hospital, Taichung, 41354, Taiwan.
- 3Graduate Institute of Biomedical Sciences, School of Medicine, China Medical University, Taichung, 40403, Taiwan.
- 4Instrument Center, Office of Research and Development, National Chung Hsing University, Taichung, 402227, Taiwan.
- 5Institute of Chemistry, Academia Sinica, Taipei, 115201, Taiwan.
- 6Department of Chemistry, National Chung Hsing University, Taichung, 402227, Taiwan.
- 7Department of Chemistry, Lady Brabourne College, Kolkata, 700017, India.
- 8Department of Obstetrics and Gynecology, Asia University Hospital, Taichung, 41354, Taiwan. [email protected].
- 9Department of Medical Research, Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, 40403, Taiwan. [email protected].
- 10Graduate Institute of Biomedical Sciences, School of Medicine, China Medical University, Taichung, 40403, Taiwan. [email protected].
- 11Office of Research and Development, Asia University, Taichung, 41354, Taiwan. [email protected].
Abstract
Cubosome based lipid nanoparticles have emerged as a premier system for drug loading and delivery. Their outstanding preclinical results underscore the importance of precision medicine for developing next generation nanomedicines. We have reported a novel engineered route for insitu formation and hybridization of cubosome based nanomaterial (lipid-g-C₃N₄-cisplatin nanoparticle), integrated with polymeric carbon nitride and cisplatin. Using an interfacial aqueous organic phase drive, we have successfully achieved cubic architecture with particle diameters of 150-200 nm. Cryogenic electron microscopy confirmed about structural integrity, while zeta potential measurements indicated to the stability with a near positive surface charge. Electron paramagnetic resonance spin trapping experiments demonstrated to the capacity of generating reactive oxygen species, specifically peroxide and superoxide. C57BL/6 mice intravenously injected with the nanoparticle which have shown preferential biodistribution in the lungs (0.09 ug Pt/g), liver (0.03 ug Pt/g), kidneys (0.06 ug Pt/g), and plasma (0.012 ug Pt/ml). The nanoparticle accumulation have exhibited a minimum in the thymus, heart, spleen, and intestines. Under dark conditions, IC₅₀ was 176.2 µg/mL for A549 cells, 139.1 µg/mL for Tong cells, and 279.3 µg/mL for HEK-293T cells. The efficacy of photodynamic therapy observed at concentrations of 50-200 µg/mL for A549 cells and 100-200 µg/mL for Tong and HEK-293T cells, highlighting that the efficiency of nanoplatform towards oncological applications in the organs of lungs, liver, and kidneys.
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BibTeX
@article{abbas2026cubosome,
title = {{Cubosome integrated with polymeric carbon nitride and cisplatin: in vivo biodistribution and in vitro photodynamic therapy studies.}},
author = {Sk Jahir Abbas and Shiraz Mehmood and Yen-Hsien Li and Sabina Yesmin and Cheng-Kuan Su and Nayim Sepay and Chih-Sheng Chiang and Wei-Chun Chang and Yao-Ching Hung and Wen-Lung Ma},
journal = {Discover nano},
year = {2026},
month = oct,
doi = {10.1186/s11671-026-05076-6},
url = {https://europepmc.org/article/MED/42955194},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Cubosome integrated with polymeric carbon nitride and cisplatin: in vivo biodistribution and in vitro photodynamic therapy studies.
AU - Sk Jahir Abbas
AU - Shiraz Mehmood
AU - Yen-Hsien Li
AU - Sabina Yesmin
AU - Cheng-Kuan Su
AU - Nayim Sepay
AU - Chih-Sheng Chiang
AU - Wei-Chun Chang
AU - Yao-Ching Hung
AU - Wen-Lung Ma
PY - 2026
DA - 2026/10/28
JO - Discover nano
DO - 10.1186/s11671-026-05076-6
UR - https://europepmc.org/article/MED/42955194
AB - Cubosome based lipid nanoparticles have emerged as a premier system for drug loading and delivery. Their outstanding preclinical results underscore the importance of precision medicine for developing next generation nanomedicines. We have reported a novel engineered route for insitu formation and hybridization of cubosome based nanomaterial (lipid-g-C₃N₄-cisplatin nanoparticle), integrated with polymeric carbon nitride and cisplatin. Using an interfacial aqueous organic phase drive, we have successfully achieved cubic architecture with particle diameters of 150-200 nm. Cryogenic electron microscopy confirmed about structural integrity, while zeta potential measurements indicated to the stability with a near positive surface charge. Electron paramagnetic resonance spin trapping experiments demonstrated to the capacity of generating reactive oxygen species, specifically peroxide and superoxide. C57BL/6 mice intravenously injected with the nanoparticle which have shown preferential biodistribution in the lungs (0.09 ug Pt/g), liver (0.03 ug Pt/g), kidneys (0.06 ug Pt/g), and plasma (0.012 ug Pt/ml). The nanoparticle accumulation have exhibited a minimum in the thymus, heart, spleen, and intestines. Under dark conditions, IC₅₀ was 176.2 µg/mL for A549 cells, 139.1 µg/mL for Tong cells, and 279.3 µg/mL for HEK-293T cells. The efficacy of photodynamic therapy observed at concentrations of 50-200 µg/mL for A549 cells and 100-200 µg/mL for Tong and HEK-293T cells, highlighting that the efficiency of nanoplatform towards oncological applications in the organs of lungs, liver, and kidneys.
SN - 2731-9229
ER -