Skip to content
DraconiticResearch
Search Sources API
182,549 studies31 sourcesUpdated 58 min ago
Peer-reviewedCC BY-NCCell adhesion & migration

FMOD marks a low-malignancy epithelial state in prostate cancer: an ECM-related prognostic signature with single-cell and functional validation.

  • Zhen Li1
  • Xinyang Cai2
  • Yichi Zhang3
  • Ning Pan3
  • Jianjun Luo1
  • Yuanwei Li1
  • Xi Guo1
  1. 1Department of Urology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China.
  2. 2Department of Urology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yatsen University Cancer Center, Guangzhou, China.
  3. 3The First Affiliated Hospital of Hunan Normal University, Health Science Center of Hunan Normal University, Changsha, China.
Read full textPDFDOICite

Abstract

Extracellular matrix (ECM) remodeling promotes prostate cancer progression, while the prognostic value and cellular context of ECM-related genes (ERGs) remain unclear. A 4-gene ERG signature for disease-free interval prediction was built using TCGA-PRAD data, and the hub gene Fibromodulin (FMOD) was validated in an external cohort via scRNA-seq, bulk deconvolution and siRNA knockdown. The signature stratified patient prognosis, and FMOD exerted the strongest protective effect. Despite higher bulk expression in tumor tissues, FMOD predicted better clinical outcomes. FMOD was enriched in a low-chromosomal-instability, low-proliferation epithelial subpopulation with enhanced stromal-immune crosstalk, and FMOD knockdown boosted cancer cell proliferation and colony formation. FMOD identifies a low-malignancy epithelial state linked to favorable prostate cancer prognosis, supporting cell state-resolved validation of ECM-related prognostic biomarkers.

Related

  1. An interpretable machine-learning signature predicts early triple-negative breast cancer recurrence but adds no prognostic value beyond clinicopathological factors in external validation
    Haocheng Nan, Rong Di, Xiaorong Kou +1
    Scientific ReportsPeer-reviewedCC BY-NC-ND 4.0Full textOncologyCrossref
  2. Kinase-based molecular subtyping and a prognostic risk model in colorectal cancer with functional validation of PLK4
    Chao Shen, Changmin Ding, Xiaofeng Han +1
    Translational cancer researchPeer-reviewedCC BY-NC-NDFull textGeneral medicineEurope PMC
  3. An Eight-Gene Metabolic Prognostic Signature in Head and Neck Squamous Cell Carcinoma: Cross-Cohort Evaluation, Single-Cell Analysis, and Preliminary Functional Evaluation of PYGL and G6PD.
    Wanyi Kou, Ruixin Guo, Yifan Zhang +10
    Journal of CancerPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  4. Prognostic Value of the Modified Endothelial Activation and Stress Index (m-EASIX) for 90-Day Mortality in Patients with Moderate-to-Severe Hypercalcemia of Malignancy
    Nevriye Gül Ada Tak, Hikmet Öztop, Fazıl Çağrı Hunutlu
    Journal of clinical medicinePeer-reviewedCC BYFull textGeneral medicineEurope PMC
  5. Electrophysiological signature of stroke recovery: investigating EEG biomarkers for prognostic insights
    Majid Khalili-Ardali, Vivek Sharma, Tarandeep Singh Mandahar +3
    Frontiers in strokePeer-reviewedCC BYFull textGeneral medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{li2026fmod,
  title = {{FMOD marks a low-malignancy epithelial state in prostate cancer: an ECM-related prognostic signature with single-cell and functional validation.}},
  author = {Zhen Li and Xinyang Cai and Yichi Zhang and Ning Pan and Jianjun Luo and Yuanwei Li and Xi Guo},
  journal = {Cell adhesion \& migration},
  year = {2026},
  month = oct,
  doi = {10.1080/19336918.2026.2728740},
  url = {https://europepmc.org/article/MED/42904786},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - FMOD marks a low-malignancy epithelial state in prostate cancer: an ECM-related prognostic signature with single-cell and functional validation.
AU  - Zhen Li
AU  - Xinyang Cai
AU  - Yichi Zhang
AU  - Ning Pan
AU  - Jianjun Luo
AU  - Yuanwei Li
AU  - Xi Guo
PY  - 2026
DA  - 2026/10/21
JO  - Cell adhesion & migration
DO  - 10.1080/19336918.2026.2728740
UR  - https://europepmc.org/article/MED/42904786
AB  - Extracellular matrix (ECM) remodeling promotes prostate cancer progression, while the prognostic value and cellular context of ECM-related genes (ERGs) remain unclear. A 4-gene ERG signature for disease-free interval prediction was built using TCGA-PRAD data, and the hub gene Fibromodulin (FMOD) was validated in an external cohort via scRNA-seq, bulk deconvolution and siRNA knockdown. The signature stratified patient prognosis, and FMOD exerted the strongest protective effect. Despite higher bulk expression in tumor tissues, FMOD predicted better clinical outcomes. FMOD was enriched in a low-chromosomal-instability, low-proliferation epithelial subpopulation with enhanced stromal-immune crosstalk, and FMOD knockdown boosted cancer cell proliferation and colony formation. FMOD identifies a low-malignancy epithelial state linked to favorable prostate cancer prognosis, supporting cell state-resolved validation of ECM-related prognostic biomarkers.
SN  - 1933-6918
SN  - 1933-6926
ER  -