Application of relative elastic modulus in patients with liver metastases from colorectal cancer receiving first-line treatment
- 1Department of Oncology,Nanjing First Hospital,Nanjing Medical University,Nanjing,Jiangsu 210006,China
Abstract
Objective To investigate the correlation of relative elastic modulus(rEM)of liver metastases and clinical characteristics with prognosis in patients with colorectal cancer liver metastases(CRLM). Methods Clinical data of 30 patients with CRLM who received first-line chemotherapy at Nanjing First Hospital from September 2023 to March 2024 were retrospectively analyzed. Two-dimensional shear wave elastography(2D-SWE)was used to measure the elastic modulus of liver metastatic lesions and adjacent normal liver parenchyma,and the rEM was calculated. Using the median rEM of 2.07 as the cut-off value,all patients were divided into the high rEM group(rEM>2.07)and the low rEM group(rEM≤2.07). Baseline characteristics were compared between the two groups. The Kaplan-Meier method was used to plot survival curves,and the log-rank test was applied to compare intergroup survival differences. Univariate and multivariate Cox regression analyses were performed to identify independent risk factors for progression-free survival(PFS)and overall survival(OS)in CRLM patients. Results Patients in the high rEM group had significantly better prognosis compared to the low rEM group. The median PFS was 11.5 months in the high rEM group versus 5.1 months in the low rEM group(P=0.032),and the median OS was 20.1 months versus 10.0 months(P=0.041). Multivariate Cox regression analysis demonstrated that low rEM was an independent risk factor for both PFS(HR=0.248,95%CI:0.094-0.657,P=0.005)and OS(HR=0.163,95%CI:0.058-0.462,P=0.001)in CRLM patients. Conclusion The rEM measured by 2D-SWE is closely associated with the prognosis of patients with CRLM. Low rEM indicates poor prognosis,which can provide a reference for clinical risk stratification and therapeutic decision-making.
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BibTeX
@article{yuhan2026application,
title = {{Application of relative elastic modulus in patients with liver metastases from colorectal cancer receiving first-line treatment}},
author = {ZHOU Yuhan and WEI Xiaowei},
journal = {Zhongguo linchuang yanjiu},
year = {2026},
month = oct,
doi = {10.13429/j.cnki.cjcr.2026.10.040},
url = {https://doi.org/10.13429/j.cnki.cjcr.2026.10.040},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Application of relative elastic modulus in patients with liver metastases from colorectal cancer receiving first-line treatment
AU - ZHOU Yuhan
AU - WEI Xiaowei
PY - 2026
DA - 2026/10/26
JO - Zhongguo linchuang yanjiu
DO - 10.13429/j.cnki.cjcr.2026.10.040
UR - https://doi.org/10.13429/j.cnki.cjcr.2026.10.040
AB - Objective To investigate the correlation of relative elastic modulus(rEM)of liver metastases and clinical characteristics with prognosis in patients with colorectal cancer liver metastases(CRLM). Methods Clinical data of 30 patients with CRLM who received first-line chemotherapy at Nanjing First Hospital from September 2023 to March 2024 were retrospectively analyzed. Two-dimensional shear wave elastography(2D-SWE)was used to measure the elastic modulus of liver metastatic lesions and adjacent normal liver parenchyma,and the rEM was calculated. Using the median rEM of 2.07 as the cut-off value,all patients were divided into the high rEM group(rEM>2.07)and the low rEM group(rEM≤2.07). Baseline characteristics were compared between the two groups. The Kaplan-Meier method was used to plot survival curves,and the log-rank test was applied to compare intergroup survival differences. Univariate and multivariate Cox regression analyses were performed to identify independent risk factors for progression-free survival(PFS)and overall survival(OS)in CRLM patients. Results Patients in the high rEM group had significantly better prognosis compared to the low rEM group. The median PFS was 11.5 months in the high rEM group versus 5.1 months in the low rEM group(P=0.032),and the median OS was 20.1 months versus 10.0 months(P=0.041). Multivariate Cox regression analysis demonstrated that low rEM was an independent risk factor for both PFS(HR=0.248,95%CI:0.094-0.657,P=0.005)and OS(HR=0.163,95%CI:0.058-0.462,P=0.001)in CRLM patients. Conclusion The rEM measured by 2D-SWE is closely associated with the prognosis of patients with CRLM. Low rEM indicates poor prognosis,which can provide a reference for clinical risk stratification and therapeutic decision-making.
SN - 1674-8182
ER -