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Peer-reviewedCC BY-NC-ND 4.0BMC Musculoskeletal Disorders

Effects of MRI-based EBQ and VBQ on adjacent segment degeneration and clinical outcomes after PLIF

  • Guohui Liu1
  • Xiuwei Zhang2
  • Chunhe Sha1
  • Zhuoyi Wu1
  • Bo Lv3
  1. 1Department of Orthopedics, Shanghai Jing’an District Zhabei Central Hospital, Shanghai, China
  2. 2Department of Orthopedics, The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, Xuzhou, China
  3. 3Department of Traumatic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, No. 150, Jimo Road, Pudong New Area, Shanghai, China
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Abstract

Objective: To explore the main and interaction effects of EBQ and VBQ on postoperative ASD, cage subsidence and clinical outcomes in L4/5 PLIF patients.

Methods: A total of 186 L4/5 PLIF patients were enrolled and followed up for at least 2 years. Using a 2 × 2 factorial design, patients were stratified into four groups according to their EBQ and VBQ scores. Preoperative baseline data, follow-up imaging parameters, and functional scores were collected to analyze EBQ/VBQ’s main and interaction effects on primary (ASD, cage subsidence) and secondary outcomes.

Results: No significant differences in preoperative baseline data were noted among the four 2 × 2 factorial design-stratified groups. VBQ and EBQ showed a significant interaction on ASD and cage subsidence incidence, with higher rates in the high-VBQ group. High-EBQ elevated rates only under high-VBQ condition. VBQ and EBQ exerted significant main effects on PT, FSA, LL and JOA scores without interaction, and only EBQ affected SS significantly. Neither VBQ nor EBQ affected disc height, ROM, Pfirrmann grades, VAS-leg scores at L3/4 and L5/S1 segments. VBQ and EBQ interacted significantly on VAS-back and ODI scores. In high-VBQ status, high-EBQ patients had higher scores than low-EBQ ones, and the same trend held in high-EBQ status.

Conclusion: EBQ and VBQ exert a significant interaction effect on ASD, cage subsidence, VAS-back and ODI scores after L4/5 PLIF, with VBQ serving as the core regulatory factor.

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Cite

BibTeXRIS
BibTeX
@article{liu2026effects,
  title = {{Effects of MRI-based EBQ and VBQ on adjacent segment degeneration and clinical outcomes after PLIF}},
  author = {Guohui Liu and Xiuwei Zhang and Chunhe Sha and Zhuoyi Wu and Bo Lv},
  journal = {BMC Musculoskeletal Disorders},
  year = {2026},
  month = aug,
  doi = {10.1186/s12891-026-10303-3},
  url = {https://doi.org/10.1186/s12891-026-10303-3},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Effects of MRI-based EBQ and VBQ on adjacent segment degeneration and clinical outcomes after PLIF
AU  - Guohui Liu
AU  - Xiuwei Zhang
AU  - Chunhe Sha
AU  - Zhuoyi Wu
AU  - Bo Lv
PY  - 2026
DA  - 2026/08/08
JO  - BMC Musculoskeletal Disorders
DO  - 10.1186/s12891-026-10303-3
UR  - https://doi.org/10.1186/s12891-026-10303-3
AB  - Objective: To explore the main and interaction effects of EBQ and VBQ on postoperative ASD, cage subsidence and clinical outcomes in L4/5 PLIF patients.  Methods: A total of 186 L4/5 PLIF patients were enrolled and followed up for at least 2 years. Using a 2 × 2 factorial design, patients were stratified into four groups according to their EBQ and VBQ scores. Preoperative baseline data, follow-up imaging parameters, and functional scores were collected to analyze EBQ/VBQ’s main and interaction effects on primary (ASD, cage subsidence) and secondary outcomes.  Results: No significant differences in preoperative baseline data were noted among the four 2 × 2 factorial design-stratified groups. VBQ and EBQ showed a significant interaction on ASD and cage subsidence incidence, with higher rates in the high-VBQ group. High-EBQ elevated rates only under high-VBQ condition. VBQ and EBQ exerted significant main effects on PT, FSA, LL and JOA scores without interaction, and only EBQ affected SS significantly. Neither VBQ nor EBQ affected disc height, ROM, Pfirrmann grades, VAS-leg scores at L3/4 and L5/S1 segments. VBQ and EBQ interacted significantly on VAS-back and ODI scores. In high-VBQ status, high-EBQ patients had higher scores than low-EBQ ones, and the same trend held in high-EBQ status.  Conclusion: EBQ and VBQ exert a significant interaction effect on ASD, cage subsidence, VAS-back and ODI scores after L4/5 PLIF, with VBQ serving as the core regulatory factor.
SN  - 1471-2474
ER  -