Practice patterns for chronic hypoparathyroidism: data from patients and physicians in France
Abstract
Context. Recent guidelines have provided recommendations for the care of patients with chronic hypoparathyroidism. Very little is known about actual physicians’ practices or their adherence to such guidelines. Objective. To describe the practice patterns and their compliance with international guidelines. Design. Cohort studies: Épi-Hypo (118 Physicians and 107 patients, from 09/2016 to 12/2019) and ePatients (110 patients, November 2019). Methods. Internet-based cohorts involving all settings at a nationwide level (France). Participants were i) physicians treating patients with chronic hypoparathyroidism and patients with chronic hypoparathyroidism either participating in the ii) Épi-Hypo study (Épi-Hypo 2019 patients) or iii) Hypoparathyroidism France, the national representative association (ePatients). Results. The physicians’ specialties were mainly endocrinology (61%), nephrology (28%), family medicine (2.5%), pediatrics (2.5%), rheumatology (2%) or miscellaneous (4%). Forty-five percent were practicing in public universities. The median number of pharmaceutical drug classes prescribed was 3 per patient. The combination of active vitamin D and calcium salt was given to 59% and 58% of ePatients and Épi-Hypo 2019 patients, respectively. Eighty-five percent of ePatients and 87% of physicians reported monitoring plasma calcium concentrations at a steady state at least twice a year. In 32% and 26% of cases, respectively, ePatients and physicians reported being fully in accordance with international guidelines that recommend targeting symptoms, plasma calcium and phosphate values, and urine calcium excretion. Conclusions. The care of patients with chronic hypoparathyroidism involves physicians with very different practices, so guidelines should include and target not only endocrinologists. Full adherence to the guidelines is low in France.
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BibTeX
@article{bertocchio2026practice,
title = {{Practice patterns for chronic hypoparathyroidism: data from patients and physicians in France}},
author = {Jean-Philippe Bertocchio and Natalie Grosset and Lionel Groussin and Peter Kamenicky and Fabrice Larceneux and Anne Lienhardt-Roussie and Agnès Linglart and Gérard Maruani and Eric Miralli and François Pattou and Riyad N.H. Seervai and Coralie Sido and Caroline Silve and Aurélie Vilfaillot and Antoine Tabarin and Marie-Christine Vantyghem and Pascal Houillier},
journal = {Endocrine Connections},
year = {2026},
month = sep,
doi = {10.1530/ec-21-0350},
url = {https://hal.sorbonne-universite.fr/hal-03510866v3},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Practice patterns for chronic hypoparathyroidism: data from patients and physicians in France
AU - Jean-Philippe Bertocchio
AU - Natalie Grosset
AU - Lionel Groussin
AU - Peter Kamenicky
AU - Fabrice Larceneux
AU - Anne Lienhardt-Roussie
AU - Agnès Linglart
AU - Gérard Maruani
AU - Eric Miralli
AU - François Pattou
AU - Riyad N.H. Seervai
AU - Coralie Sido
AU - Caroline Silve
AU - Aurélie Vilfaillot
AU - Antoine Tabarin
AU - Marie-Christine Vantyghem
AU - Pascal Houillier
PY - 2026
DA - 2026/09/14
JO - Endocrine Connections
DO - 10.1530/ec-21-0350
UR - https://hal.sorbonne-universite.fr/hal-03510866v3
AB - Context. Recent guidelines have provided recommendations for the care of patients with chronic hypoparathyroidism. Very little is known about actual physicians’ practices or their adherence to such guidelines. Objective. To describe the practice patterns and their compliance with international guidelines. Design. Cohort studies: Épi-Hypo (118 Physicians and 107 patients, from 09/2016 to 12/2019) and ePatients (110 patients, November 2019). Methods. Internet-based cohorts involving all settings at a nationwide level (France). Participants were i) physicians treating patients with chronic hypoparathyroidism and patients with chronic hypoparathyroidism either participating in the ii) Épi-Hypo study (Épi-Hypo 2019 patients) or iii) Hypoparathyroidism France, the national representative association (ePatients). Results. The physicians’ specialties were mainly endocrinology (61%), nephrology (28%), family medicine (2.5%), pediatrics (2.5%), rheumatology (2%) or miscellaneous (4%). Forty-five percent were practicing in public universities. The median number of pharmaceutical drug classes prescribed was 3 per patient. The combination of active vitamin D and calcium salt was given to 59% and 58% of ePatients and Épi-Hypo 2019 patients, respectively. Eighty-five percent of ePatients and 87% of physicians reported monitoring plasma calcium concentrations at a steady state at least twice a year. In 32% and 26% of cases, respectively, ePatients and physicians reported being fully in accordance with international guidelines that recommend targeting symptoms, plasma calcium and phosphate values, and urine calcium excretion. Conclusions. The care of patients with chronic hypoparathyroidism involves physicians with very different practices, so guidelines should include and target not only endocrinologists. Full adherence to the guidelines is low in France.
SN - 2049-3614
ER -