Prognostic value of C-reactive protein-albumin-lymphocyte (CALLY) score and CRP-albumin ratio on mortality in patients diagnosed with pulmonary thromboembolism
- 1lazig Fethi Sekin City Hospital, Emergency Medicine, Elazığ, Türkiye
Abstract
BackgroundAcute pulmonary embolism (PE) requires rapid risk stratification to predict early mortality. We aimed to evaluate the prognostic value of the C-reactive protein-albumin-lymphocyte (CALLY) index and C-reactive protein-to-albumin ratio (CAR) in predicting in-hospital mortality among patients with PE.MethodsThis retrospective, single-center Study Included 399 Patients Diagnosed with Acute PE Between 2021 and 2025. the Clinical Characteristics and Baseline Laboratory Parameters Were Analyzed. Receiver Operating Characteristic (ROC) Curves Were Used to Determine the Optimal Biomarker cut-offs. Univariate and Multivariate Logistic Regression Models Were Constructed to Evaluate the Independent Predictors of MortalityResultsNon-survivors (n=88,22.0%) had significantly lower CALLY indices (0.71 vs. 1.56,p<0.001) and higher CAR values (2.37 vs. 0.93,p<0.001) than survivors (n=311,78.0%). The AUC was 0.655 for CALLY (<1.17 cut-off; 69.1% sensitivity, 57.7% specificity, 86.4% NPV) and 0.643 for CAR (>3.28 cut-off; 42.0% sensitivity, 83.2% specificity, 83.2% NPV) (DeLong test, p=0.582). In multivariate models adjusted for age, sex, and serum creatinine, both a low CALLY index (<1.17; aOR=2.54,95%CI:1.46−4.50,p=0.001) and a high CAR (>3.28; aOR=3.02,95%CI:1.66−5.50,p<0.001) served as independent predictors of in-hospital mortality.ConclusionThe baseline CALLY index is a simple, cost-effective, and readily Accessible Biomarker That Independently Predicts in-hospital mortality in Patients with Acute PE. A CALLY Index <1.17 Provides Moderate Sensitivity for Early Emergency Department Risk Stratification, though its overall discriminative performance is modest
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BibTeX
@article{aydemir2026prognostic,
title = {{Prognostic value of C-reactive protein-albumin-lymphocyte (CALLY) score and CRP-albumin ratio on mortality in patients diagnosed with pulmonary thromboembolism}},
author = {Ahmet Mert Aydemir},
journal = {Frontiers in Medicine},
year = {2026},
month = oct,
doi = {10.3389/fmed.2026.1944670},
url = {https://doi.org/10.3389/fmed.2026.1944670},
note = {CC BY},
}
RIS
TY - JOUR
TI - Prognostic value of C-reactive protein-albumin-lymphocyte (CALLY) score and CRP-albumin ratio on mortality in patients diagnosed with pulmonary thromboembolism
AU - Ahmet Mert Aydemir
PY - 2026
DA - 2026/10/26
JO - Frontiers in Medicine
DO - 10.3389/fmed.2026.1944670
UR - https://doi.org/10.3389/fmed.2026.1944670
AB - BackgroundAcute pulmonary embolism (PE) requires rapid risk stratification to predict early mortality. We aimed to evaluate the prognostic value of the C-reactive protein-albumin-lymphocyte (CALLY) index and C-reactive protein-to-albumin ratio (CAR) in predicting in-hospital mortality among patients with PE.MethodsThis retrospective, single-center Study Included 399 Patients Diagnosed with Acute PE Between 2021 and 2025. the Clinical Characteristics and Baseline Laboratory Parameters Were Analyzed. Receiver Operating Characteristic (ROC) Curves Were Used to Determine the Optimal Biomarker cut-offs. Univariate and Multivariate Logistic Regression Models Were Constructed to Evaluate the Independent Predictors of MortalityResultsNon-survivors (n=88,22.0%) had significantly lower CALLY indices (0.71 vs. 1.56,p<0.001) and higher CAR values (2.37 vs. 0.93,p<0.001) than survivors (n=311,78.0%). The AUC was 0.655 for CALLY (<1.17 cut-off; 69.1% sensitivity, 57.7% specificity, 86.4% NPV) and 0.643 for CAR (>3.28 cut-off; 42.0% sensitivity, 83.2% specificity, 83.2% NPV) (DeLong test, p=0.582). In multivariate models adjusted for age, sex, and serum creatinine, both a low CALLY index (<1.17; aOR=2.54,95%CI:1.46−4.50,p=0.001) and a high CAR (>3.28; aOR=3.02,95%CI:1.66−5.50,p<0.001) served as independent predictors of in-hospital mortality.ConclusionThe baseline CALLY index is a simple, cost-effective, and readily Accessible Biomarker That Independently Predicts in-hospital mortality in Patients with Acute PE. A CALLY Index <1.17 Provides Moderate Sensitivity for Early Emergency Department Risk Stratification, though its overall discriminative performance is modest
SN - 2296-858X
ER -