High frequency electrical stimulation paces fast spiking interneurons and modulates cellular information processing
- 1Department of Biomedical Engineering, Boston University
- 2Department of Neuroscience, Erasmus Medical University Center
Abstract
High frequency intracranial electrical stimulation is routinely used in the clinic, but its therapeutic mechanisms are unclear. Since most neurons cannot follow fast inputs, high frequency neuromodulation is theorized to disrupt pathological dynamics, therefore creating functional informational lesion. However, fast spiking interneurons (FSIs) fire rapidly and thus may be differentially engaged by high frequency neuromodulation. To understand how intracranial electrical stimulation impacts FSIs and their ability to process inputs, we measured the real-time effect of stimulation using cellular voltage imaging in awake mice. We report that visual cortex FSIs, but not motor cortex ones, are reliably paced by high frequency 140 Hz stimulation, though suppressed by low frequency 40 Hz stimulation. Furthermore, 140 Hz stimulation powerfully reduces the amplitude of visual flicker-evoked FSI responses. Thus, high-frequency neuromodulation leads to brain-region dependent pacing of FSIs and modulates their cellular processing of inputs.
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BibTeX
@article{fabris2026high,
title = {{High frequency electrical stimulation paces fast spiking interneurons and modulates cellular information processing}},
author = {Pierre Fabris and Eric Lowet and Krishnakanth Kondabolu and Yangyang Wang and Yuxin Zhou and Erynne San Antonio and Xue Han},
journal = {Communications Biology},
year = {2026},
month = jul,
doi = {10.1038/s42003-026-10539-8},
url = {https://doi.org/10.1038/s42003-026-10539-8},
note = {CC BY},
}
RIS
TY - JOUR
TI - High frequency electrical stimulation paces fast spiking interneurons and modulates cellular information processing
AU - Pierre Fabris
AU - Eric Lowet
AU - Krishnakanth Kondabolu
AU - Yangyang Wang
AU - Yuxin Zhou
AU - Erynne San Antonio
AU - Xue Han
PY - 2026
DA - 2026/07/01
JO - Communications Biology
DO - 10.1038/s42003-026-10539-8
UR - https://doi.org/10.1038/s42003-026-10539-8
AB - High frequency intracranial electrical stimulation is routinely used in the clinic, but its therapeutic mechanisms are unclear. Since most neurons cannot follow fast inputs, high frequency neuromodulation is theorized to disrupt pathological dynamics, therefore creating functional informational lesion. However, fast spiking interneurons (FSIs) fire rapidly and thus may be differentially engaged by high frequency neuromodulation. To understand how intracranial electrical stimulation impacts FSIs and their ability to process inputs, we measured the real-time effect of stimulation using cellular voltage imaging in awake mice. We report that visual cortex FSIs, but not motor cortex ones, are reliably paced by high frequency 140 Hz stimulation, though suppressed by low frequency 40 Hz stimulation. Furthermore, 140 Hz stimulation powerfully reduces the amplitude of visual flicker-evoked FSI responses. Thus, high-frequency neuromodulation leads to brain-region dependent pacing of FSIs and modulates their cellular processing of inputs.
SN - 2399-3642
ER -