Elderly-Onset Sarcoidosis and the Influence of Age on Clinical Phenotypes: A Multicentre Analysis from the SARCOGEAS Registry

@article{garciagonzalez2026elderlyonset,
  title = {{Elderly-Onset Sarcoidosis and the Influence of Age on Clinical Phenotypes: A Multicentre Analysis from the SARCOGEAS Registry}},
  author = {María García-González and Carlos Feijoo-Massó and Alejandra Flores-Chávez and Guillem Policarpo-Torres and Ricardo Gómez de la Torre and Begoña de Escalante Yangüela and Jesús Miguel López-Dupla and Cristina Soler-I-Ferrer and Eva Fonseca-Aizpuru and Andrés González-García and Rosana Rouco and Salvador García Morillo and Ana Alguacil and Ana Noblejas-Mozo and Mariona Bonet and María Barrientos and Antonio-J. Chamorro and Borja De Miguel-Campo and Maria Gracia Cruz Caparrós and Miriam Akasbi Montalvo and Alex Mayer-Fuentes and Manuel Ramos-Casals and Pilar Brito-Zerón},
  journal = {Journal of Clinical Medicine},
  year = {2026},
  month = oct,
  doi = {10.3390/jcm15218355},
  url = {https://www.mdpi.com/2077-0383/15/21/8355},
  note = {CC BY 4.0},
}

TY  - JOUR
TI  - Elderly-Onset Sarcoidosis and the Influence of Age on Clinical Phenotypes: A Multicentre Analysis from the SARCOGEAS Registry
AU  - María García-González
AU  - Carlos Feijoo-Massó
AU  - Alejandra Flores-Chávez
AU  - Guillem Policarpo-Torres
AU  - Ricardo Gómez de la Torre
AU  - Begoña de Escalante Yangüela
AU  - Jesús Miguel López-Dupla
AU  - Cristina Soler-I-Ferrer
AU  - Eva Fonseca-Aizpuru
AU  - Andrés González-García
AU  - Rosana Rouco
AU  - Salvador García Morillo
AU  - Ana Alguacil
AU  - Ana Noblejas-Mozo
AU  - Mariona Bonet
AU  - María Barrientos
AU  - Antonio-J. Chamorro
AU  - Borja De Miguel-Campo
AU  - Maria Gracia Cruz Caparrós
AU  - Miriam Akasbi Montalvo
AU  - Alex Mayer-Fuentes
AU  - Manuel Ramos-Casals
AU  - Pilar Brito-Zerón
PY  - 2026
DA  - 2026/10/27
JO  - Journal of Clinical Medicine
DO  - 10.3390/jcm15218355
UR  - https://www.mdpi.com/2077-0383/15/21/8355
AB  - Background/Objectives: To determine the proportion of elderly-onset sarcoidosis (EOS) and to assess the influence of age at diagnosis on pulmonary and extrapulmonary manifestations. Methods: Retrospective multicentre study using the Spanish SARCOGEAS registry, including adults with sarcoidosis diagnosed across 36 hospitals. EOS was defined as diagnosis at ≥65 years. Associations between clinical features and age were assessed using multivariable logistic and linear regression models, including sex-stratified analyses. Results: Among 2187 patients (mean age 48.6 ± 15.2 years, 61.36% women), 358 (16.37%) had EOS. In multivariable analyses, female sex (OR 1.86; β +5.02 years), White ethnicity (OR 5.43; β +4.85 years), and renal involvement (OR 2.29; β +6.86 years) were independently associated with EOS and older age at diagnosis, whereas cutaneous (OR 0.49; β −3.50 years), articular or bone (OR 0.37; β −3.10 years), and neurological involvement (OR 0.49; β −2.47 years) were associated with non-EOS and younger age at diagnosis. Exploratory sex-stratified analyses suggested additional patterns: in women, calcium metabolism abnormalities were associated with EOS (OR 1.74) and older age at diagnosis (β +4.91 years), and ear–nose–throat involvement was associated with older age at diagnosis (β +5.74 years). Regarding pulmonary involvement, CT-based Scadding stage II was associated with younger age at diagnosis (β −3.75 years) in women and CT-based Scadding stage IV with older age at diagnosis (β +6.57 years) in men. Conclusions: EOS accounted for 16.37% of sarcoidosis cases. Older age at diagnosis was associated with specific patterns of organ involvement, which changed gradually across the age spectrum, some of them differing by sex in exploratory analyses. Further studies are needed to confirm these findings.
SN  - 2077-0383
ER  -