Onsite DADQs-assisted chemiluminescence wavelength shift from luminol µPADs to tetracyanoquinodimethane-based fluorophores enabling sensitised emission of AuNPs in point-of-source testing (PoST) multimode device.
- 1Department of Chemistry, Birla Institute of Technology and Science, Pilani-Hyderabad Campus Jawahar Nagar, Kapra Mandal, Medchal Malkajgiri District Hyderabad 500078 Telangana India [email protected].
- 2MEMS, Microfluidics and Nanoelectronics Laboratory, Department of Electrical and Electronics Engineering, Birla Institute of Technology and Science Pilani Hyderabad 500078 Telangana India.
- 3Department of Chemistry, Indian Institute of Technology Kharagpur 721302 India.
Abstract
The rapid advancement of small-molecule-based fluorophores is attributed to their highly tunable optical properties, which enable notable applications in biomedical, environmental research and demand cost-effective, user-friendly alternatives for deployment in remote locations. Accordingly, we have synthesised and characterised a new class of simple tetracyanoquinodimethane (TCNQ) derivatives with different amine substituents referred to as diaminodicyanoquinodimethane fluorophores (DADQs), i.e. BMOPDQ [1], BCDMDQ [2], BEPDQ [3], BMPPDQ [4], and BCPPDQ [5]. At the outset, herein we introduce and demonstrate a novel approach that utilises a sequential sensitised emission process, in which the first step involves DADQ-assisted chemiluminescence (CL) wavelength shift, followed by optical sensitisation of gold nanoparticles (AuNPs), in a point-of-source testing (PoST) multimode optical detection system. The photons emitted from the luminol-based chemiexcited species are transferred to DADQs via an optical absorption. The resulting green emission from DADQs ascertains the sensitised emission of AuNPs, which emit a red signal. Moreover, the blue emission of the chemiluminiscent signal can be shifted to longer wavelengths without any complex instrumental setup, making it suitable for real-world applications. Thus, the PoST platform provides a compact, sensitive, and selective method for detecting various analytes, including biomarkers and metal ions, using small sample volumes without the requirement of bulky instrumentation. Furthermore, a PoST-reliable device could enable luminescence techniques to reach remote areas for portable on-site testing.
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BibTeX
@article{mohitkar2026onsite,
title = {{Onsite DADQs-assisted chemiluminescence wavelength shift from luminol µPADs to tetracyanoquinodimethane-based fluorophores enabling sensitised emission of AuNPs in point-of-source testing (PoST) multimode device.}},
author = {Anuradha Sureshrao Mohitkar and Pavar Sai Kumar and Rituparna Sinha and Sabyashachi Mishra and Sanket Goel and Subbalakshmi Jayanty},
journal = {RSC advances},
year = {2026},
month = oct,
doi = {10.1039/d6ra08375g},
url = {https://europepmc.org/article/MED/42903338},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Onsite DADQs-assisted chemiluminescence wavelength shift from luminol µPADs to tetracyanoquinodimethane-based fluorophores enabling sensitised emission of AuNPs in point-of-source testing (PoST) multimode device.
AU - Anuradha Sureshrao Mohitkar
AU - Pavar Sai Kumar
AU - Rituparna Sinha
AU - Sabyashachi Mishra
AU - Sanket Goel
AU - Subbalakshmi Jayanty
PY - 2026
DA - 2026/10/20
JO - RSC advances
DO - 10.1039/d6ra08375g
UR - https://europepmc.org/article/MED/42903338
AB - The rapid advancement of small-molecule-based fluorophores is attributed to their highly tunable optical properties, which enable notable applications in biomedical, environmental research and demand cost-effective, user-friendly alternatives for deployment in remote locations. Accordingly, we have synthesised and characterised a new class of simple tetracyanoquinodimethane (TCNQ) derivatives with different amine substituents referred to as diaminodicyanoquinodimethane fluorophores (DADQs), i.e. BMOPDQ [1], BCDMDQ [2], BEPDQ [3], BMPPDQ [4], and BCPPDQ [5]. At the outset, herein we introduce and demonstrate a novel approach that utilises a sequential sensitised emission process, in which the first step involves DADQ-assisted chemiluminescence (CL) wavelength shift, followed by optical sensitisation of gold nanoparticles (AuNPs), in a point-of-source testing (PoST) multimode optical detection system. The photons emitted from the luminol-based chemiexcited species are transferred to DADQs via an optical absorption. The resulting green emission from DADQs ascertains the sensitised emission of AuNPs, which emit a red signal. Moreover, the blue emission of the chemiluminiscent signal can be shifted to longer wavelengths without any complex instrumental setup, making it suitable for real-world applications. Thus, the PoST platform provides a compact, sensitive, and selective method for detecting various analytes, including biomarkers and metal ions, using small sample volumes without the requirement of bulky instrumentation. Furthermore, a PoST-reliable device could enable luminescence techniques to reach remote areas for portable on-site testing.
SN - 2046-2069
ER -