Skip to content
DraconiticResearch
Search Sources API
203,948 studies31 sourcesUpdated 23 min ago
Peer-reviewedCC BY 4.0Journal of Clinical Medicine

Glycemic Status, Stent Count, and In-Stent Restenosis: Exploratory Decomposition and Sex-Related Analyses in a Retrospective Cohort

  • Yuan Wang1
  • Yan Zhuang1
  • Liao Zhang1
  • Haiyan Song1
  1. 1Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China
Open at sourceDOICite

Abstract

Background/Objectives: Fasting blood glucose (FBG) and stent count have been associated with in-stent restenosis (ISR), but their interrelationships remain unclear. We evaluated the FBG–ISR association and explored baseline stent count as a potential mediator. Methods: This single-center retrospective cohort comprised 510 patients with follow-up angiography after percutaneous coronary intervention (PCI). Analyses included multivariable regression, exploratory decomposition in 468 patients sampled before PCI, and intravascular imaging analyses in 284 patients. Results: ISR was observed in 56 patients (11.0%). The adjusted FBG–ISR odds ratio (OR) was 1.100 per mmol/L (95% confidence interval [CI] 1.001–1.208; p = 0.048); Firth and diabetes-adjusted CIs included 1. For FBG increasing from 5.07 to 7.59 mmol/L, the indirect component associated with baseline stent count was 0.48 percentage points (95% CI 0.06 to 1.05); the direct and total CIs included zero. Exploratory analyses suggested higher direct-effect estimates in men and positive indirect-effect estimates in women; between-sex indirect differences remained uncertain. Higher stent count was associated with underexpansion, which was associated with ISR (adjusted OR 4.47, 95% CI 1.85–10.78). Conclusions: Higher FBG showed a modest positive association with ISR, with uncertainty across sensitivity analyses. Exploratory analyses yielded a positive indirect estimate for stent count and linked underexpansion to ISR.

Related

  1. Admission Leuko-Glycemic Index and In-Hospital Mortality in Patients with Acute Surgical Abdomen: An Exploratory Retrospective Cohort Study.
    Andrei Modiga, Vlad-Olimpiu Butiurca, Cristian Marius Boeriu +7
    Medicina (Kaunas, Lithuania)Peer-reviewedCC BYFull textOncologyEurope PMC
  2. Exploratory associations between CT-derived body composition and MRI-based infrapatellar fat pad profiles with age-stratified analyses: a retrospective cross-sectional study.
    Seunghyun Song, Hee Sang Oh, Sungjun Kim +1
    BMC musculoskeletal disordersPeer-reviewedCC BY-NC-NDFull textGeneral medicineEurope PMCPMC
  3. Pathological complete response and long-term outcomes after neoadjuvant therapy for breast cancer: a multicenter retrospective cohort study with exploratory subtype analyses
    Shaolong Fu, Kaiyang Xiao, Sibao Huang +3
    Frontiers in OncologyPeer-reviewedCC BY 4.0Full textOncologyCrossrefDOAJEurope PMC
  4. Effects of saffron and crocin on glycemic control: an exploratory systematic review and meta-analysis of randomized trials
    J. Kim, M. Schaffer, G. Kim +5
    medRxivPreprintAll rights reservedFull textEndocrinology & metabolismmedRxiv
  5. Nomogram for predicting post-percutaneous coronary intervention restenosis in patients with coronary artery disease and diabetes: a retrospective study
    Ping Wang, Hongyu Peng, Qian Fan +2
    PeerJPeer-reviewedCC BY 4.0Full textSurgery & anaesthesiaCrossref

Cite

BibTeXRIS
BibTeX
@article{wang2026glycemic,
  title = {{Glycemic Status, Stent Count, and In-Stent Restenosis: Exploratory Decomposition and Sex-Related Analyses in a Retrospective Cohort}},
  author = {Yuan Wang and Yan Zhuang and Liao Zhang and Haiyan Song},
  journal = {Journal of Clinical Medicine},
  year = {2026},
  month = nov,
  doi = {10.3390/jcm15218685},
  url = {https://www.mdpi.com/2077-0383/15/21/8685},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Glycemic Status, Stent Count, and In-Stent Restenosis: Exploratory Decomposition and Sex-Related Analyses in a Retrospective Cohort
AU  - Yuan Wang
AU  - Yan Zhuang
AU  - Liao Zhang
AU  - Haiyan Song
PY  - 2026
DA  - 2026/11/07
JO  - Journal of Clinical Medicine
DO  - 10.3390/jcm15218685
UR  - https://www.mdpi.com/2077-0383/15/21/8685
AB  - Background/Objectives: Fasting blood glucose (FBG) and stent count have been associated with in-stent restenosis (ISR), but their interrelationships remain unclear. We evaluated the FBG–ISR association and explored baseline stent count as a potential mediator. Methods: This single-center retrospective cohort comprised 510 patients with follow-up angiography after percutaneous coronary intervention (PCI). Analyses included multivariable regression, exploratory decomposition in 468 patients sampled before PCI, and intravascular imaging analyses in 284 patients. Results: ISR was observed in 56 patients (11.0%). The adjusted FBG–ISR odds ratio (OR) was 1.100 per mmol/L (95% confidence interval [CI] 1.001–1.208; p = 0.048); Firth and diabetes-adjusted CIs included 1. For FBG increasing from 5.07 to 7.59 mmol/L, the indirect component associated with baseline stent count was 0.48 percentage points (95% CI 0.06 to 1.05); the direct and total CIs included zero. Exploratory analyses suggested higher direct-effect estimates in men and positive indirect-effect estimates in women; between-sex indirect differences remained uncertain. Higher stent count was associated with underexpansion, which was associated with ISR (adjusted OR 4.47, 95% CI 1.85–10.78). Conclusions: Higher FBG showed a modest positive association with ISR, with uncertainty across sensitivity analyses. Exploratory analyses yielded a positive indirect estimate for stent count and linked underexpansion to ISR.
SN  - 2077-0383
ER  -