Fetal goiter treated antenatally with intra-amniotic thyroxine: A case report.
6 affiliations
- 1Department of Endocrinology and Diabetes, University Maternity and Neonatology Hospital of Córdoba, Faculty of Medical Sciences, National University of Córdoba, Rodríguez Peña 285, X5000 Córdoba, Argentina.
- 2Diagnus Academy of Fetal Medicine, 9 de Julio 726, X5000 Córdoba, Argentina.
- 3Postgraduate School of Health, Postgraduate Faculty, Holy Spirit University, Km 2.5 Vía a Samborondón, Samborondón 092301, Ecuador.
- 4Pediatric Endocrinology Service, Clínica Universitaria Reina Fabiola, Faculty of Medical Sciences, Catholic University of Córdoba, Oncativo 1248, X5004 Córdoba, Argentina.
- 5Laboratory of Endocrinology, Genetics, and Molecular Biology, Diagnus-Lab, 9 de Julio 726, X5000 Córdoba, Argentina.
- 6Laboratory of Endocrinology, Fundación para el Progreso de la Medicina, 9 de Julio 941, X5000EMS Córdoba, Argentina.
Abstract
Fetal goiter may compromise the airway and complicate delivery. Prenatal management requires assessment of fetal thyroid function and the mass effect of the enlarged gland. A fetal neck mass was detected at 18 + 5 weeks of gestation in a 32-year-old woman with a history of Hashimoto thyroiditis. Ultrasonography confirmed a bilobed goiter with neck hyperextension and apparent tracheal compression, and fetal hypothyroidism was confirmed by cordocentesis. Eleven intra-amniotic levothyroxine injections were administered between 24 + 4 and 35 + 6 weeks of gestation, initially at a dose of 400 μg and subsequently increased to 600 μg. Serial ultrasonography and hormonal monitoring showed progressive reduction in thyroid volume, resolution of the apparent tracheal compression, and restoration of normal fetal neck flexion. Following premature rupture of membranes, a girl was delivered by cesarean section at 36 + 3 weeks without a clinically apparent goiter. She received neonatal levothyroxine and, at 14 months, showed adequate growth and normal neurological and psychomotor development. Prenatal imaging and assessment of fetal thyroid function can identify thyroid disorders that may be amenable to treatment in utero. In the absence of a standardized intra-amniotic levothyroxine regimen, treatment should be individualized and coordinated by a multidisciplinary team.
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BibTeX
@article{fuxotta2026fetal,
title = {{Fetal goiter treated antenatally with intra-amniotic thyroxine: A case report.}},
author = {Carolina Fux-Otta and Peter Chedraui and Graciela Testa and Sergio A Ochoa and Diana Torre and José H Ochoa},
journal = {Case reports in women's health},
year = {2026},
month = oct,
doi = {10.1016/j.crwh.2026.e00867},
url = {https://europepmc.org/article/MED/42997629},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Fetal goiter treated antenatally with intra-amniotic thyroxine: A case report.
AU - Carolina Fux-Otta
AU - Peter Chedraui
AU - Graciela Testa
AU - Sergio A Ochoa
AU - Diana Torre
AU - José H Ochoa
PY - 2026
DA - 2026/10/24
JO - Case reports in women's health
DO - 10.1016/j.crwh.2026.e00867
UR - https://europepmc.org/article/MED/42997629
AB - Fetal goiter may compromise the airway and complicate delivery. Prenatal management requires assessment of fetal thyroid function and the mass effect of the enlarged gland. A fetal neck mass was detected at 18 + 5 weeks of gestation in a 32-year-old woman with a history of Hashimoto thyroiditis. Ultrasonography confirmed a bilobed goiter with neck hyperextension and apparent tracheal compression, and fetal hypothyroidism was confirmed by cordocentesis. Eleven intra-amniotic levothyroxine injections were administered between 24 + 4 and 35 + 6 weeks of gestation, initially at a dose of 400 μg and subsequently increased to 600 μg. Serial ultrasonography and hormonal monitoring showed progressive reduction in thyroid volume, resolution of the apparent tracheal compression, and restoration of normal fetal neck flexion. Following premature rupture of membranes, a girl was delivered by cesarean section at 36 + 3 weeks without a clinically apparent goiter. She received neonatal levothyroxine and, at 14 months, showed adequate growth and normal neurological and psychomotor development. Prenatal imaging and assessment of fetal thyroid function can identify thyroid disorders that may be amenable to treatment in utero. In the absence of a standardized intra-amniotic levothyroxine regimen, treatment should be individualized and coordinated by a multidisciplinary team.
SN - 2214-9112
ER -