NLR–TyG index and prevalent chronic kidney disease in hypertension: a cross-population study
4 affiliations
- 1Department of General Practice, People's Hospital of Tengchong City , , ,
- 2Department of Cardiology, The Second People’s Hospital of Baoshan City Yunnan Province , , ,
- 3College of Health Science and Technology, West Yunnan University of Applied Sciences , , ,
- 4Department of Cardiology, The First Affiliated Hospital of Dali University , , ,
Abstract
Background: Inflammation and metabolic dysfunction are interrelated in chronic kidney disease (CKD). The NLR–TyG index (NTI), calculated from the neutrophil-to-lymphocyte ratio (NLR) and triglyceride–glucose (TyG) index, summarizes concurrent inflammatory and metabolic burden. We examined its association with prevalent CKD in hypertensive adults from a Chinese cardiology inpatient population and the US National Health and Nutrition Examination Survey (NHANES).
Methods: This cross-sectional study included hypertensive adults from the Department of Cardiology, First Affiliated Hospital of Dali University, and NHANES. NTI was analyzed continuously and by cohort-specific quartiles. Multivariable logistic regression and restricted cubic splines assessed associations. Subgroup, sensitivity, and incremental discrimination analyses were also performed.
Results: The analysis included 8,358 hospital participants (1,800 with CKD) and 9,182 NHANES participants (2,751 with CKD). In fully adjusted models, each 1-unit increase in NTI was associated with higher odds of CKD in the hospital population [odds ratio (OR), 1.012; 95% confidence interval (CI), 1.010–1.014] and NHANES (OR, 1.021; 95% CI, 1.013–1.029; both p < 0.001). Compared with the lowest NTI quartile, the highest quartile was associated with higher CKD odds in the hospital population (OR, 2.85; 95% CI, 2.38–3.40) and NHANES (OR, 1.93; 95% CI, 1.56–2.38; both P for trend <0.001). Significant nonlinearity was detected only in the hospital population. Associations persisted among participants with known non-use of lipid-lowering therapy. Adding NTI increased the C statistic from 0.769 to 0.778 in the hospital population and from 0.772 to 0.778 in NHANES; discrimination was similar when NLR and TyG were entered separately.
Conclusion: Higher NTI was independently associated with prevalent CKD in both hypertensive populations and provided modest incremental discrimination. NTI may offer a simple summary of inflammatory–metabolic burden, but prospective prediction and clinical utility require further validation.
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BibTeX
@article{li2026nlrtyg,
title = {{NLR–TyG index and prevalent chronic kidney disease in hypertension: a cross-population study}},
author = {Honglin Li and Chuanwei Zhao and Mingpeng Zhao and Xinhua Wu},
journal = {Frontiers in nutrition},
year = {2026},
month = oct,
doi = {10.3389/fnut.2026.1917577},
url = {https://europepmc.org/article/PMC/PMC13724347},
note = {CC BY},
}
RIS
TY - JOUR
TI - NLR–TyG index and prevalent chronic kidney disease in hypertension: a cross-population study
AU - Honglin Li
AU - Chuanwei Zhao
AU - Mingpeng Zhao
AU - Xinhua Wu
PY - 2026
DA - 2026/10/19
JO - Frontiers in nutrition
DO - 10.3389/fnut.2026.1917577
UR - https://europepmc.org/article/PMC/PMC13724347
AB - Background: Inflammation and metabolic dysfunction are interrelated in chronic kidney disease (CKD). The NLR–TyG index (NTI), calculated from the neutrophil-to-lymphocyte ratio (NLR) and triglyceride–glucose (TyG) index, summarizes concurrent inflammatory and metabolic burden. We examined its association with prevalent CKD in hypertensive adults from a Chinese cardiology inpatient population and the US National Health and Nutrition Examination Survey (NHANES). Methods: This cross-sectional study included hypertensive adults from the Department of Cardiology, First Affiliated Hospital of Dali University, and NHANES. NTI was analyzed continuously and by cohort-specific quartiles. Multivariable logistic regression and restricted cubic splines assessed associations. Subgroup, sensitivity, and incremental discrimination analyses were also performed. Results: The analysis included 8,358 hospital participants (1,800 with CKD) and 9,182 NHANES participants (2,751 with CKD). In fully adjusted models, each 1-unit increase in NTI was associated with higher odds of CKD in the hospital population [odds ratio (OR), 1.012; 95% confidence interval (CI), 1.010–1.014] and NHANES (OR, 1.021; 95% CI, 1.013–1.029; both p < 0.001). Compared with the lowest NTI quartile, the highest quartile was associated with higher CKD odds in the hospital population (OR, 2.85; 95% CI, 2.38–3.40) and NHANES (OR, 1.93; 95% CI, 1.56–2.38; both P for trend <0.001). Significant nonlinearity was detected only in the hospital population. Associations persisted among participants with known non-use of lipid-lowering therapy. Adding NTI increased the C statistic from 0.769 to 0.778 in the hospital population and from 0.772 to 0.778 in NHANES; discrimination was similar when NLR and TyG were entered separately. Conclusion: Higher NTI was independently associated with prevalent CKD in both hypertensive populations and provided modest incremental discrimination. NTI may offer a simple summary of inflammatory–metabolic burden, but prospective prediction and clinical utility require further validation.
SN - 2296-861X
ER -