Dietary Rosa roxburghii Tratt polysaccharides improve intestinal health and alleviate deoxynivalenol-induced oxidative stress and immune imbalance in broilers
- 1College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China
- 2Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, China
- 3Joint International Research Laboratory of Agriculture and Agri-Product Safety, Ministry of Education of China, Yangzhou University, Yangzhou, 225009, China
Abstract
Deoxynivalenol (DON) is a common mycotoxin contaminating poultry feed, which can induce oxidative stress, immune disorders and barrier damage in the intestinal tract of broilers, seriously affecting performance and feed safety. Rosa roxburghii Tratt polysaccharides (RRTPs), a characteristic wild plant resource, have been reported to have antioxidant and immunomodulatory activities. However, whether RRTPs can effectively combat DON induced intestinal disorders in broilers has not been systematically studied. In this study, one-day-old male broilers were acclimated for 3 days and then subjected to dietary supplementation with RRTPs (100, 200, and 400 mg/kg diet) under normal conditions or combined with DON exposure (4 mg/kg diet) for 42 days to evaluate the protective effects of RRTPs against DON-associated intestinal injury. The results showed that under normal physiological conditions, RRTPs could improve body weight gain and feed efficiency, up-regulate the expression of tight junction proteins, modulate jejunal microbiota composition without significantly altering microbial diversity, and enhance mucosal innate immune defense. Under DON exposure, RRTPs significantly reduced the contents of intestinal reactive oxygen species and malondialdehyde, restored the total antioxidant capacity and mitochondrial DNA content, inhibited cGAS-STING-related signaling responses, and regulated the expression of markers associated with M1/M2 macrophages. In summary, RRTPs supplementation alleviated DON-associated intestinal injury by improving redox status and immune-related responses, providing insights into the potential application of Rosa roxburghii Tratt polysaccharides in mycotoxin risk mitigation.
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BibTeX
@article{wang2026dietary,
title = {{Dietary Rosa roxburghii Tratt polysaccharides improve intestinal health and alleviate deoxynivalenol-induced oxidative stress and immune imbalance in broilers}},
author = {Xinbo Wang and Yichao Liu and Jinwen Ge and Pengli Liu and Guodong Cai and Ruilong Song and Hui Zou and Jianhong Gu and Yan Yuan and Xuezhong Liu and Zongping Liu and Jianchun Bian},
journal = {Poultry Science},
year = {2026},
month = oct,
doi = {10.1016/j.psj.2026.108035},
url = {https://doi.org/10.1016/j.psj.2026.108035},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Dietary Rosa roxburghii Tratt polysaccharides improve intestinal health and alleviate deoxynivalenol-induced oxidative stress and immune imbalance in broilers
AU - Xinbo Wang
AU - Yichao Liu
AU - Jinwen Ge
AU - Pengli Liu
AU - Guodong Cai
AU - Ruilong Song
AU - Hui Zou
AU - Jianhong Gu
AU - Yan Yuan
AU - Xuezhong Liu
AU - Zongping Liu
AU - Jianchun Bian
PY - 2026
DA - 2026/10/24
JO - Poultry Science
DO - 10.1016/j.psj.2026.108035
UR - https://doi.org/10.1016/j.psj.2026.108035
AB - Deoxynivalenol (DON) is a common mycotoxin contaminating poultry feed, which can induce oxidative stress, immune disorders and barrier damage in the intestinal tract of broilers, seriously affecting performance and feed safety. Rosa roxburghii Tratt polysaccharides (RRTPs), a characteristic wild plant resource, have been reported to have antioxidant and immunomodulatory activities. However, whether RRTPs can effectively combat DON induced intestinal disorders in broilers has not been systematically studied. In this study, one-day-old male broilers were acclimated for 3 days and then subjected to dietary supplementation with RRTPs (100, 200, and 400 mg/kg diet) under normal conditions or combined with DON exposure (4 mg/kg diet) for 42 days to evaluate the protective effects of RRTPs against DON-associated intestinal injury. The results showed that under normal physiological conditions, RRTPs could improve body weight gain and feed efficiency, up-regulate the expression of tight junction proteins, modulate jejunal microbiota composition without significantly altering microbial diversity, and enhance mucosal innate immune defense. Under DON exposure, RRTPs significantly reduced the contents of intestinal reactive oxygen species and malondialdehyde, restored the total antioxidant capacity and mitochondrial DNA content, inhibited cGAS-STING-related signaling responses, and regulated the expression of markers associated with M1/M2 macrophages. In summary, RRTPs supplementation alleviated DON-associated intestinal injury by improving redox status and immune-related responses, providing insights into the potential application of Rosa roxburghii Tratt polysaccharides in mycotoxin risk mitigation.
SN - 0032-5791
SN - 1525-3171
ER -