Optimizing Preexposure Prophylaxis Adherence: Evaluating Point-of-Care Urine Tenofovir Testing and Tailored…

Abstract

Among South African women using oral HIV preexposure prophylaxis, we compared a urine tenofovir point-of-care test with dried blood spot tenofovir diphosphate concentrations for recent vs longer-term adherence and assessed acceptability. The test demonstrated 76% accuracy, 100% sensitivity, and 69% specificity for high adherence (tenofovir diphosphate ≥700 fmol/punch) and was highly acceptable.

Clinical Trials Registration: NCT04038060.

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BibTeX RIS

BibTeX

@article{poovan2026optimizing,
  title = {{Optimizing Preexposure Prophylaxis Adherence: Evaluating Point-of-Care Urine Tenofovir Testing and Tailored Counseling Among Young South African Women}},
  author = {Nicole Poovan and Jennifer Velloza and Nontokozo H Ndlovu and Allison Meisner and Cole Grabow and Monica Gandhi and Deborah Donnell and Sybil Hosek and Connie Celum and Sinead Delany-Moretlwe},
  journal = {Open forum infectious diseases},
  year = {2026},
  month = nov,
  doi = {10.1093/ofid/ofag612},
  url = {https://europepmc.org/article/PMC/PMC13728699},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Optimizing Preexposure Prophylaxis Adherence: Evaluating Point-of-Care Urine Tenofovir Testing and Tailored Counseling Among Young South African Women
AU  - Nicole Poovan
AU  - Jennifer Velloza
AU  - Nontokozo H Ndlovu
AU  - Allison Meisner
AU  - Cole Grabow
AU  - Monica Gandhi
AU  - Deborah Donnell
AU  - Sybil Hosek
AU  - Connie Celum
AU  - Sinead Delany-Moretlwe
PY  - 2026
DA  - 2026/11/01
JO  - Open forum infectious diseases
DO  - 10.1093/ofid/ofag612
UR  - https://europepmc.org/article/PMC/PMC13728699
AB  - Among South African women using oral HIV preexposure prophylaxis, we compared a urine tenofovir point-of-care test with dried blood spot tenofovir diphosphate concentrations for recent vs longer-term adherence and assessed acceptability. The test demonstrated 76% accuracy, 100% sensitivity, and 69% specificity for high adherence (tenofovir diphosphate ≥700 fmol/punch) and was highly acceptable.  Clinical Trials Registration: NCT04038060.
SN  - 2328-8957
ER  -

Abstract

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