Albuminuria and associated renal and hemodynamic factors in adults with steady-state sickle cell disease: a multicenter study with measured GFR.

@article{engole2026albuminuria,
  title = {{Albuminuria and associated renal and hemodynamic factors in adults with steady-state sickle cell disease: a multicenter study with measured GFR.}},
  author = {Yannick Mompango Engole and Justine Busanga Bukabau and Yannick Mayamba Nlandu and Aliocha Natuhoyila Nkodila and Brady Makanzu and Jean-Robert Rissassy Makulo and François Musungayi Kajingulu and Vieux Momeme Mokoli and Marie-France Ingole Mboliasa and Evariste Mukendi Kadima and Chantal Zinga Vuvu and Daddy Mbiso Liombo and Jonathan Musa and Blaise Nkolomoni and Ange Ngonde and Ernest Kiswaya Sumaili},
  journal = {BMC nephrology},
  year = {2026},
  month = jul,
  doi = {10.1186/s12882-026-05247-8},
  url = {https://europepmc.org/article/MED/42958048},
  note = {CC BY-NC-ND},
}

TY  - JOUR
TI  - Albuminuria and associated renal and hemodynamic factors in adults with steady-state sickle cell disease: a multicenter study with measured GFR.
AU  - Yannick Mompango Engole
AU  - Justine Busanga Bukabau
AU  - Yannick Mayamba Nlandu
AU  - Aliocha Natuhoyila Nkodila
AU  - Brady Makanzu
AU  - Jean-Robert Rissassy Makulo
AU  - François Musungayi Kajingulu
AU  - Vieux Momeme Mokoli
AU  - Marie-France Ingole Mboliasa
AU  - Evariste Mukendi Kadima
AU  - Chantal Zinga Vuvu
AU  - Daddy Mbiso Liombo
AU  - Jonathan Musa
AU  - Blaise Nkolomoni
AU  - Ange Ngonde
AU  - Ernest Kiswaya Sumaili
PY  - 2026
DA  - 2026/07/31
JO  - BMC nephrology
DO  - 10.1186/s12882-026-05247-8
UR  - https://europepmc.org/article/MED/42958048
AB  - Background  Albuminuria is an early marker of renal involvement in sickle cell disease (SCD) and is associated with progressive renal function decline. However, data on albuminuria in adults with SCD in sub-Saharan Africa remain limited. This study aimed to determine the prevalence of albuminuria and identify factors associated with albuminuria in adults with steady-state SCD in Kinshasa, Democratic Republic of the Congo.Methods  We conducted a multicenter cross-sectional study involving 279 adults (aged ≥ 18 years) with steady-state SCD. Albuminuria was assessed using the urinary albumin-to-creatinine ratio (UACR) and classified according to KDIGO categories. Glomerular filtration rate (GFR) was directly measured by plasma iohexol clearance. Cardiac function was evaluated by Doppler echocardiography, and arterial stiffness was assessed using pulse wave velocity (PWV). Multivariable linear and logistic regression analyses were performed to identify factors associated with albuminuria.Results  The overall prevalence of albuminuria was 29.1%, including 21.5% with KDIGO A2 and 7.5% with A3 albuminuria. In multivariable linear regression, higher PWV was independently associated with increased albuminuria (β = 2.086, 95% CI: 1.036-3.208; p < 0.001), whereas lower systemic vascular resistance (SVR) was inversely associated with albuminuria (β = -0.311, 95% CI: -0.762 to -0.001 p = 0.029). In multivariable logistic regression, urinary α-1 microglobulin ≥ 12 mg/L (aOR 3.01, 95% CI 1.80-4.02), recent vaso-occlusive crisis (aOR 2.71, 95% CI 1.22-4.21), LDH > 246 IU/L (aOR 3.57, 95% CI 2.40-6.13), and SVR < 700 dyn·s/cm⁵ (aOR 1.91, 95% CI 1.51-7.15) were independently associated with albuminuria.Conclusions  Albuminuria was common in this cohort of adults with steady-state SCD and was associated with markers of hemolysis, tubular injury, recent vaso-occlusive events, and systemic hemodynamic alterations. These findings suggest that albuminuria may be associated with a broader pattern of cardiorenal vulnerability in adults with SCD.
SN  - 1471-2369
ER  -