Controlled postoperative red wine intake versus abstinence in habitual wine drinkers undergoing elective urological surgery (WISE): a translational randomized controlled trial assessing quality of life, surgical outcomes and complications.
5 affiliations
- 1IRCCS San Raffaele Scientific Institute, Urological Research Institute (URI), Milan, Italy. [email protected].
- 2University Vita-Salute San Raffaele, Milan, Italy. [email protected].
- 3IRCCS San Raffaele Scientific Institute, Urological Research Institute (URI), Milan, Italy.
- 4University Vita-Salute San Raffaele, Milan, Italy.
- 5Department of Clinical and Health Psychology, IRCCS San Raffaele Hospital, Milan, Italy.
Abstract
Background
To date, no prospective randomized study has evaluated whether controlled postoperative red wine intake, compared with abstinence, affects recovery in habitual wine drinkers undergoing surgery.Methods
In this single-center randomized controlled trial (NCT05261620), habitual wine drinkers scheduled for elective urological surgery were randomized 1:1 to abstinence from alcohol (Control Arm) or standardized red wine intake (150 mL of 13% v/v red wine with lunch and with dinner) from postoperative day 1 to day 30 (Experimental Arm). The primary endpoint was the between-group difference in change from baseline to 30 days in the SF-36 Mental Health Index (MHI). Secondary endpoints included postoperative complications, hospital readmission, length of hospitalization, blood parameters, and oxidative stress markers.Results
The mean change in MHI was - 0.6 in the Control Arm and + 0.7 in the Experimental Arm (difference 1.3 points; 95% CI - 1.9 to 4.6; p = 0.4). Overall complications (16.1% vs. 9.8%; p = 0.4), length of hospital stay and 30-day readmissions (8.1% vs. 0%; p = 0.06) did not differ significantly between the Control and Experimental Arms, respectively. Blood parameters and oxidative stress markers showed no clinically relevant differences.Conclusions
Among predominantly older male habitual wine drinkers undergoing elective urological surgery, controlled postoperative red wine intake did not improve 30-day quality of life compared with abstinence. Complications and blood parameters did not differ meaningfully. These findings do not support the initiation or promotion of alcohol use.Trial registration
This study was registered with ClinicalTrials.gov (NCT05261620, registered on 02/20/2022. https://clinicaltrials.gov/study/NCT05261620 ).
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BibTeX
@article{capitanio2026controlled,
title = {{Controlled postoperative red wine intake versus abstinence in habitual wine drinkers undergoing elective urological surgery (WISE): a translational randomized controlled trial assessing quality of life, surgical outcomes and complications.}},
author = {Umberto Capitanio and Giuseppe Basile and Cristina Barrasso and Alexandra Derevianko and Giacomo Musso and Francesco Cei and Natasha Disabato and Chiara Re and Federico Belladelli and Ciro Piccolo and Giuseppe Rosiello and Daniela Canibus and Francesco Trevisani and Alessandro Larcher and Andrea Salonia and Arianna Bettiga and Maria Monica Ratti and Francesco Montorsi},
journal = {World journal of urology},
year = {2026},
month = oct,
doi = {10.1007/s00345-026-06890-4},
url = {https://europepmc.org/article/MED/42955358},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Controlled postoperative red wine intake versus abstinence in habitual wine drinkers undergoing elective urological surgery (WISE): a translational randomized controlled trial assessing quality of life, surgical outcomes and complications.
AU - Umberto Capitanio
AU - Giuseppe Basile
AU - Cristina Barrasso
AU - Alexandra Derevianko
AU - Giacomo Musso
AU - Francesco Cei
AU - Natasha Disabato
AU - Chiara Re
AU - Federico Belladelli
AU - Ciro Piccolo
AU - Giuseppe Rosiello
AU - Daniela Canibus
AU - Francesco Trevisani
AU - Alessandro Larcher
AU - Andrea Salonia
AU - Arianna Bettiga
AU - Maria Monica Ratti
AU - Francesco Montorsi
PY - 2026
DA - 2026/10/28
JO - World journal of urology
DO - 10.1007/s00345-026-06890-4
UR - https://europepmc.org/article/MED/42955358
AB - Background To date, no prospective randomized study has evaluated whether controlled postoperative red wine intake, compared with abstinence, affects recovery in habitual wine drinkers undergoing surgery.Methods In this single-center randomized controlled trial (NCT05261620), habitual wine drinkers scheduled for elective urological surgery were randomized 1:1 to abstinence from alcohol (Control Arm) or standardized red wine intake (150 mL of 13% v/v red wine with lunch and with dinner) from postoperative day 1 to day 30 (Experimental Arm). The primary endpoint was the between-group difference in change from baseline to 30 days in the SF-36 Mental Health Index (MHI). Secondary endpoints included postoperative complications, hospital readmission, length of hospitalization, blood parameters, and oxidative stress markers.Results The mean change in MHI was - 0.6 in the Control Arm and + 0.7 in the Experimental Arm (difference 1.3 points; 95% CI - 1.9 to 4.6; p = 0.4). Overall complications (16.1% vs. 9.8%; p = 0.4), length of hospital stay and 30-day readmissions (8.1% vs. 0%; p = 0.06) did not differ significantly between the Control and Experimental Arms, respectively. Blood parameters and oxidative stress markers showed no clinically relevant differences.Conclusions Among predominantly older male habitual wine drinkers undergoing elective urological surgery, controlled postoperative red wine intake did not improve 30-day quality of life compared with abstinence. Complications and blood parameters did not differ meaningfully. These findings do not support the initiation or promotion of alcohol use.Trial registration This study was registered with ClinicalTrials.gov (NCT05261620, registered on 02/20/2022. https://clinicaltrials.gov/study/NCT05261620 ).
SN - 0724-4983
SN - 1433-8726
ER -