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Peer-reviewedLicence not statedNature

Human lung organoid modelling of tissue-resident antiviral T cell responses

  • Joseph K. Rathkey1,2,3
  • S. S. Choi1,4
  • Vincent van Unen5,1,6,7
  • Huimin Zhang1,4
  • Min Liu1,4
  • Jie Ding1,4
  • Samira Alwahabi1,4
  • António J. M. Santos1,3
  • Vamsee V. A. Mallajosyula5,6,8
  • Joshua Elbridge Chan1,8
  • Azam Mohsin6,8
  • Maher M. Elsheikh1,4
27 more authors
  • Arjun Rustagi9,8
  • Brandon Krishna Lam10,3
  • Steven M. Chirieleison10,1,3
  • Bailey Wallen11,8
  • Daniel Solis10,12
  • Jordan Mah10,4
  • Hudson T. Horn1,8
  • Katharina Röltgen10,8
  • Ramesh V. Nair13,14
  • Winston Trope11,12
  • Alexander Guh‐Siesel1,4
  • Zhongqi Lin1,4
  • Hannah S. Powell1,15,7
  • Ahmad Salehi16,17,7
  • Aimee Beck18
  • Caitlin E. Edwards19
  • Brock A. Martin10
  • James Dunn20
  • Joseph B. Shrager11
  • Ralph Steven Baric19
  • Benjamin A. Pinsky10
  • Scott Dexter Boyd10
  • Catherine A. Blish21,18,6
  • Alessandro Sette22,23
  • Alba Grifoni22,23
  • Mark M. Davis5,6
  • Calvin Jay Kuo24,25
25 affiliations
  1. 1Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
  2. 2Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
  3. 3Division of Hematology, Stanford University School of Medicine
  4. 4Stanford University
  5. 5Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA
  6. 6Stanford Institute of Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA
  7. 7Stanford Institute of Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA
  8. 8Stanford University School of Medicine
  9. 9Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
  10. 10Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
  11. 11Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA
  12. 12Department of Microbiology and Immunology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
  13. 13Stanford Center for Genomics and Personalized Medicine, Stanford University School of Medicine, Stanford, CA, USA
  14. 14Stanford Division of Thoracic Surgery
  15. 15Chan Zuckerberg Biohub, San Francisco, CA 94158, USA
  16. 16Donor Network West, San Ramon, CA, USA
  17. 17Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
  18. 18Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
  19. 19Department of Epidemiology, Microbiology, and Immunology, University of North Carolina Chapel Hill, Chapel Hill, NC, USA
  20. 20Department of Pediatric Surgery, Stanford University School of Medicine, Stanford, CA, USA
  21. 21Chan Zuckerberg Biohub, San Francisco, CA, USA
  22. 22Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA
  23. 23Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA, USA
  24. 24Arc Institute, Palo Alto, CA, USA. [email protected]
  25. 25Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. [email protected]
Open at sourcePDFDOICite

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Cite

BibTeXRIS
BibTeX
@article{rathkey2026human,
  title = {{Human lung organoid modelling of tissue-resident antiviral T cell responses}},
  author = {Joseph K. Rathkey and S. S. Choi and Vincent van Unen and Huimin Zhang and Min Liu and Jie Ding and Samira Alwahabi and António J. M. Santos and Vamsee V. A. Mallajosyula and Joshua Elbridge Chan and Azam Mohsin and Maher M. Elsheikh and Arjun Rustagi and Brandon Krishna Lam and Steven M. Chirieleison and Bailey Wallen and Daniel Solis and Jordan Mah and Hudson T. Horn and Katharina Röltgen and Ramesh V. Nair and Winston Trope and Alexander Guh‐Siesel and Zhongqi Lin and Hannah S. Powell and Ahmad Salehi and Aimee Beck and Caitlin E. Edwards and Brock A. Martin and James Dunn and Joseph B. Shrager and Ralph Steven Baric and Benjamin A. Pinsky and Scott Dexter Boyd and Catherine A. Blish and Alessandro Sette and Alba Grifoni and Mark M. Davis and Calvin Jay Kuo},
  journal = {Nature},
  year = {2026},
  month = oct,
  doi = {10.1038/s41586-026-11114-1},
  url = {https://doi.org/10.21203/rs.3.rs-2870695/v1},
}
RIS
TY  - JOUR
TI  - Human lung organoid modelling of tissue-resident antiviral T cell responses
AU  - Joseph K. Rathkey
AU  - S. S. Choi
AU  - Vincent van Unen
AU  - Huimin Zhang
AU  - Min Liu
AU  - Jie Ding
AU  - Samira Alwahabi
AU  - António J. M. Santos
AU  - Vamsee V. A. Mallajosyula
AU  - Joshua Elbridge Chan
AU  - Azam Mohsin
AU  - Maher M. Elsheikh
AU  - Arjun Rustagi
AU  - Brandon Krishna Lam
AU  - Steven M. Chirieleison
AU  - Bailey Wallen
AU  - Daniel Solis
AU  - Jordan Mah
AU  - Hudson T. Horn
AU  - Katharina Röltgen
AU  - Ramesh V. Nair
AU  - Winston Trope
AU  - Alexander Guh‐Siesel
AU  - Zhongqi Lin
AU  - Hannah S. Powell
AU  - Ahmad Salehi
AU  - Aimee Beck
AU  - Caitlin E. Edwards
AU  - Brock A. Martin
AU  - James Dunn
AU  - Joseph B. Shrager
AU  - Ralph Steven Baric
AU  - Benjamin A. Pinsky
AU  - Scott Dexter Boyd
AU  - Catherine A. Blish
AU  - Alessandro Sette
AU  - Alba Grifoni
AU  - Mark M. Davis
AU  - Calvin Jay Kuo
PY  - 2026
DA  - 2026/10/07
JO  - Nature
DO  - 10.1038/s41586-026-11114-1
UR  - https://doi.org/10.21203/rs.3.rs-2870695/v1
SN  - 0028-0836
SN  - 1476-4687
ER  -