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Peer-reviewedCC BYJournal of agricultural and food chemistry

Oxidomics of Human Plasma Reveals Lower Oxidized Lipids After Acute Intake of Polyphenol-Enriched Flaxseed Oil: A Randomized Crossover Exercise Trial.

  • Fawzan Sigma Aurum1,2
  • Julia Brem1
  • Matthias Strauss1,3
  • Markus Gassner4,5
  • Daniel König4,6,5
  • Marc Pignitter1
6 affiliations
  1. 1Institute of Physiological Chemistry, Faculty of Chemistry, University of Vienna, Josef-Holaubek-Platz 2, Vienna1090, Austria.
  2. 2Research Center for Food Technology and Processing, National Research and Innovation Agency, Yogyakarta55861, Indonesia.
  3. 3Vienna Doctoral School in Chemistry (DoSChem), Faculty of Chemistry, University of Vienna, Währinger Str. 42, Vienna1090, Austria.
  4. 4Department of Nutrition, Faculty of Life Sciences, Section for Nutrition, Exercise and Health, University of Vienna, Vienna1090, Austria.
  5. 5Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, Josef-Holaubek-Platz, Vienna1090, Austria.
  6. 6Centre for Sport Science and University Sports, Department of Sports Science, Section for Nutrition, Exercise and Health, University of Vienna, Auf der Schmelz 6, Vienna1150, Austria.
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Abstract

Dietary antioxidants offer protection against oxidative bursts caused by high-intensity physical exercise. However, their acute effects on specific lipid oxidation products, especially oxidized phosphatidylcholine (oxPC) and oxysterols, remain underexplored in human plasma. Nineteen female participants underwent a crossover study involving pre-exercise intake of either polyphenol-enriched flaxseed oil (FO) or water (control), followed by standardized high-intensity interval training (HIIT). Plasma collected at four time points (pre- to post-HIIT) was analyzed via targeted LC-MS/MS for oxPCs and oxysterols and untargeted lipidomics using LC-QTOF-MS. FO significantly suppressed the postexercise rise in oxPCs (e.g., SONPC, KOOA-PC, KDdiA-PC) and nonenzymatically formed oxysterols (7-ketocholesterol, 7β-hydroxycholesterol). Orthogonal PLS-DA showed obvious postexercise group separation between FO-consuming subjects versus control. Untargeted lipidomics revealed broader remodeling of the phospholipidome in the FO group. This study provides novel evidence that polyphenol-rich FO acutely mitigates lipid peroxidation, supporting its potential as a nutritional strategy for oxidative stress management.

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Cite

BibTeXRIS
BibTeX
@article{aurum2026oxidomics,
  title = {{Oxidomics of Human Plasma Reveals Lower Oxidized Lipids After Acute Intake of Polyphenol-Enriched Flaxseed Oil: A Randomized Crossover Exercise Trial.}},
  author = {Fawzan Sigma Aurum and Julia Brem and Matthias Strauss and Markus Gassner and Daniel König and Marc Pignitter},
  journal = {Journal of agricultural and food chemistry},
  year = {2026},
  month = oct,
  doi = {10.1021/acs.jafc.6c08737},
  url = {https://europepmc.org/article/MED/42915783},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Oxidomics of Human Plasma Reveals Lower Oxidized Lipids After Acute Intake of Polyphenol-Enriched Flaxseed Oil: A Randomized Crossover Exercise Trial.
AU  - Fawzan Sigma Aurum
AU  - Julia Brem
AU  - Matthias Strauss
AU  - Markus Gassner
AU  - Daniel König
AU  - Marc Pignitter
PY  - 2026
DA  - 2026/10/01
JO  - Journal of agricultural and food chemistry
DO  - 10.1021/acs.jafc.6c08737
UR  - https://europepmc.org/article/MED/42915783
AB  - Dietary antioxidants offer protection against oxidative bursts caused by high-intensity physical exercise. However, their acute effects on specific lipid oxidation products, especially oxidized phosphatidylcholine (oxPC) and oxysterols, remain underexplored in human plasma. Nineteen female participants underwent a crossover study involving pre-exercise intake of either polyphenol-enriched flaxseed oil (FO) or water (control), followed by standardized high-intensity interval training (HIIT). Plasma collected at four time points (pre- to post-HIIT) was analyzed via targeted LC-MS/MS for oxPCs and oxysterols and untargeted lipidomics using LC-QTOF-MS. FO significantly suppressed the postexercise rise in oxPCs (e.g., SONPC, KOOA-PC, KDdiA-PC) and nonenzymatically formed oxysterols (7-ketocholesterol, 7β-hydroxycholesterol). Orthogonal PLS-DA showed obvious postexercise group separation between FO-consuming subjects versus control. Untargeted lipidomics revealed broader remodeling of the phospholipidome in the FO group. This study provides novel evidence that polyphenol-rich FO acutely mitigates lipid peroxidation, supporting its potential as a nutritional strategy for oxidative stress management.
SN  - 0021-8561
SN  - 1520-5118
ER  -