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Peer-reviewedCC BY-NCAlzheimer's & dementia (Amsterdam, Netherlands)

Global, regional, and national burden of anxiety-related Alzheimer's disease and Alzheimer's-related dementias among older adults from 1995 to 2021: A comparative risk assessment study.

  • Jiayao Ying1,2
  • Jiali Zhou1,2
  • Shiyi Shan1,2
  • Xinyu Liu1,2
  • Longzhu Zhu1,2
  • Chenyue Xu3
  • Zeyu Luo1,2
  • Jing Wu1,2
  • Peige Song1,2,4
4 affiliations
  1. 1Center of Clinical Big Data and Analytics of the Second Affiliated Hospital and School of Public Health Zhejiang University School of Medicine Hangzhou Zhejiang China.
  2. 2Center for Global Health Zhejiang University School of Medicine Hangzhou Zhejiang China.
  3. 3Department of Psychiatry, the First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China.
  4. 4Zhejiang Key Laboratory of Intelligent Preventive Medicine Hangzhou Zhejiang China.
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Abstract

This study aimed to quantify the global dementia burden attributable to anxiety disorders among older adults. We searched PubMed, Embase, and MEDLINE through July, 2024 for cohort studies examining anxiety-related dementia risk, and pooled risk ratios (RRs). Prevalence of anxiety disorders and disability-adjusted life-years (DALYs) for dementia were obtained from Global Burden of Disease (GBD) 2021. Attributable age-standardized DALY rates (ASDRs) were estimated for 1995-2021, with trends and cross-country inequalities assessed. Fourteen studies met inclusion. Anxiety disorders were associated with increased dementia risk (RR: 1.14). Globally, attributable ASDRs declined slightly (23.54 to 22.52 per 100,000, 1995-2021). Highest burdens were observed in Europe and high-middle sociodemographic index (SDI) regions in 2021, while the fastest increases occurred in South-East Asian and low-middle SDI regions. Global inequalities persisted over time. Anxiety contributes to dementia burden in older adults, highlighting the need for targeted interventions in countries and regions with high anxiety-attributable dementia burden.

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Cite

BibTeXRIS
BibTeX
@article{ying2026global,
  title = {{Global, regional, and national burden of anxiety-related Alzheimer's disease and Alzheimer's-related dementias among older adults from 1995 to 2021: A comparative risk assessment study.}},
  author = {Jiayao Ying and Jiali Zhou and Shiyi Shan and Xinyu Liu and Longzhu Zhu and Chenyue Xu and Zeyu Luo and Jing Wu and Peige Song},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year = {2026},
  month = oct,
  doi = {10.1002/dad2.70537},
  url = {https://europepmc.org/article/MED/42996801},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Global, regional, and national burden of anxiety-related Alzheimer's disease and Alzheimer's-related dementias among older adults from 1995 to 2021: A comparative risk assessment study.
AU  - Jiayao Ying
AU  - Jiali Zhou
AU  - Shiyi Shan
AU  - Xinyu Liu
AU  - Longzhu Zhu
AU  - Chenyue Xu
AU  - Zeyu Luo
AU  - Jing Wu
AU  - Peige Song
PY  - 2026
DA  - 2026/10/01
JO  - Alzheimer's & dementia (Amsterdam, Netherlands)
DO  - 10.1002/dad2.70537
UR  - https://europepmc.org/article/MED/42996801
AB  - This study aimed to quantify the global dementia burden attributable to anxiety disorders among older adults. We searched PubMed, Embase, and MEDLINE through July, 2024 for cohort studies examining anxiety-related dementia risk, and pooled risk ratios (RRs). Prevalence of anxiety disorders and disability-adjusted life-years (DALYs) for dementia were obtained from Global Burden of Disease (GBD) 2021. Attributable age-standardized DALY rates (ASDRs) were estimated for 1995-2021, with trends and cross-country inequalities assessed. Fourteen studies met inclusion. Anxiety disorders were associated with increased dementia risk (RR: 1.14). Globally, attributable ASDRs declined slightly (23.54 to 22.52 per 100,000, 1995-2021). Highest burdens were observed in Europe and high-middle sociodemographic index (SDI) regions in 2021, while the fastest increases occurred in South-East Asian and low-middle SDI regions. Global inequalities persisted over time. Anxiety contributes to dementia burden in older adults, highlighting the need for targeted interventions in countries and regions with high anxiety-attributable dementia burden.
SN  - 2352-8729
ER  -