Genomic resilience of aquatic microbes in Sangam: insights from the Mahakumbh event
Abstract
The Mahakumbh festival at Prayagraj represents an exceptionally intense and temporally concentrated anthropogenic perturbation superimposed on the dynamic riverine ecosystem at the confluence of the Ganga and Yamuna rivers. The large gathering of people during the festival can alter organic loading, nutrient availability, turbidity, dissolved oxygen, microbial inputs, and exposure to pharmaceutical, fecal, and other anthropogenic contaminants, thereby providing a valuable natural observational framework for investigating microbial community responses to environmental disturbance. This review synthesizes current evidence on the structural organization, functional potential, and stress-response mechanisms of riverine microbiota in the Mahakumbh region. It discusses how metagenomics, metatranscriptomics, metaproteomics, metabolomics, and viromics can be integrated to distinguish microbial community composition from functional potential and active biochemical responses. It pays particular attention to stress-response pathways, xenobiotic transformation, metal-resistance determinants, antibiotic-resistance genes, biofilm-associated functions, mobile genetic elements, and potential horizontal gene transfer. Importantly, the presence or increased abundance of functional genes is distinguished from their expression, biochemical activity, and demonstrated contribution to microbial fitness or ecological resilience. Candidate ecogenomic biomarkers, oxidative-stress genes and antibiotic-resistance determinants, are discussed as potential indicators for environmental surveillance and validation when integrated with physicochemical and microbiological measurements. This review also describes how longitudinal, spatially resolved multi-omics monitoring can support moving from perturbations in the environment to functional and taxonomic responses of microbial communities over different time scales. Such integrated ecogenomic frameworks could provide means to detect ecological changes in their infancy while also assisting evidence-based management and conservation of aquatic ecosystems at local and wider spatial scales.
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BibTeX
@article{guru2026genomic,
title = {{Genomic resilience of aquatic microbes in Sangam: insights from the Mahakumbh event}},
author = {Gurudayal Ram Guru and Pramod W. Ramteke and Csilla Veres and Csaba Vágvölgyi and Rita Büchner and Dayanand P. Gogle},
journal = {Frontiers in Microbiology},
year = {2026},
month = nov,
doi = {10.3389/fmicb.2026.1783734},
url = {https://www.frontiersin.org/articles/10.3389/fmicb.2026.1783734},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Genomic resilience of aquatic microbes in Sangam: insights from the Mahakumbh event
AU - Gurudayal Ram Guru
AU - Pramod W. Ramteke
AU - Csilla Veres
AU - Csaba Vágvölgyi
AU - Rita Büchner
AU - Dayanand P. Gogle
PY - 2026
DA - 2026/11/09
JO - Frontiers in Microbiology
DO - 10.3389/fmicb.2026.1783734
UR - https://www.frontiersin.org/articles/10.3389/fmicb.2026.1783734
AB - The Mahakumbh festival at Prayagraj represents an exceptionally intense and temporally concentrated anthropogenic perturbation superimposed on the dynamic riverine ecosystem at the confluence of the Ganga and Yamuna rivers. The large gathering of people during the festival can alter organic loading, nutrient availability, turbidity, dissolved oxygen, microbial inputs, and exposure to pharmaceutical, fecal, and other anthropogenic contaminants, thereby providing a valuable natural observational framework for investigating microbial community responses to environmental disturbance. This review synthesizes current evidence on the structural organization, functional potential, and stress-response mechanisms of riverine microbiota in the Mahakumbh region. It discusses how metagenomics, metatranscriptomics, metaproteomics, metabolomics, and viromics can be integrated to distinguish microbial community composition from functional potential and active biochemical responses. It pays particular attention to stress-response pathways, xenobiotic transformation, metal-resistance determinants, antibiotic-resistance genes, biofilm-associated functions, mobile genetic elements, and potential horizontal gene transfer. Importantly, the presence or increased abundance of functional genes is distinguished from their expression, biochemical activity, and demonstrated contribution to microbial fitness or ecological resilience. Candidate ecogenomic biomarkers, oxidative-stress genes and antibiotic-resistance determinants, are discussed as potential indicators for environmental surveillance and validation when integrated with physicochemical and microbiological measurements. This review also describes how longitudinal, spatially resolved multi-omics monitoring can support moving from perturbations in the environment to functional and taxonomic responses of microbial communities over different time scales. Such integrated ecogenomic frameworks could provide means to detect ecological changes in their infancy while also assisting evidence-based management and conservation of aquatic ecosystems at local and wider spatial scales.
SN - 1664-302X
ER -