Attenuated alpha state transitions and disrupted repetition-dependent temporal adaptation in mild cognitive impairment
- 1Affiliated Hospital of Jiangsu University
Abstract
Mild cognitive impairment (MCI) may involve impaired dynamic regulation of brain states that is not captured by conventional resting-state electroencephalography (EEG). We quantified occipital alpha (8-12 Hz) transitions during three repeated eye-opening/eye-closure cycles in 60 healthy controls (HC) and 77 participants with MCI. Eye-state events were refined from frontal ocular artifacts. Transition magnitude was measured by the log-transformed post-/pre-event energy ratio, and transition success by the expected direction of alpha change. For canonical transitions meeting prespecified fit-quality criteria, mono-exponential fitting yielded transition onset (tonset) and the post-onset time constant ({tau}). MCI showed weaker alpha suppression during eye opening, weaker alpha enhancement during eye closure, and lower odds of transition success. No significant group difference in {tau} was detected within the canonical quality-controlled subset. In contrast, tonset showed significant Group x Trial interactions in both conditions: HC developed later onset during eye opening and earlier onset during eye closure across repetitions, whereas MCI showed no comparable change. These findings suggest reduced alpha state-transition capacity and altered repetition-dependent temporal organization in MCI.
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BibTeX
@misc{wang2026attenuated,
title = {{Attenuated alpha state transitions and disrupted repetition-dependent temporal adaptation in mild cognitive impairment}},
author = {X. Wang and Y. Zhu and J. Zhang and z. zheng and M. Yu},
howpublished = {medRxiv},
year = {2026},
month = oct,
doi = {10.64898/2026.10.10.26365211},
url = {https://www.medrxiv.org/content/10.64898/2026.10.10.26365211v1},
note = {CC BY-NC},
}
RIS
TY - UNPB
TI - Attenuated alpha state transitions and disrupted repetition-dependent temporal adaptation in mild cognitive impairment
AU - X. Wang
AU - Y. Zhu
AU - J. Zhang
AU - z. zheng
AU - M. Yu
PY - 2026
DA - 2026/10/10
PB - medRxiv
DO - 10.64898/2026.10.10.26365211
UR - https://www.medrxiv.org/content/10.64898/2026.10.10.26365211v1
AB - Mild cognitive impairment (MCI) may involve impaired dynamic regulation of brain states that is not captured by conventional resting-state electroencephalography (EEG). We quantified occipital alpha (8-12 Hz) transitions during three repeated eye-opening/eye-closure cycles in 60 healthy controls (HC) and 77 participants with MCI. Eye-state events were refined from frontal ocular artifacts. Transition magnitude was measured by the log-transformed post-/pre-event energy ratio, and transition success by the expected direction of alpha change. For canonical transitions meeting prespecified fit-quality criteria, mono-exponential fitting yielded transition onset (tonset) and the post-onset time constant ({tau}). MCI showed weaker alpha suppression during eye opening, weaker alpha enhancement during eye closure, and lower odds of transition success. No significant group difference in {tau} was detected within the canonical quality-controlled subset. In contrast, tonset showed significant Group x Trial interactions in both conditions: HC developed later onset during eye opening and earlier onset during eye closure across repetitions, whereas MCI showed no comparable change. These findings suggest reduced alpha state-transition capacity and altered repetition-dependent temporal organization in MCI.
ER -