Lethal Viral Sepsis/Septic Shock in Getah Virus-Infected Ifnar1-/- Mice.
4 affiliations
- 1Infection and Inflammation Department, QIMR Berghofer, Brisbane, QLD 4029, Australia.
- 2School of Chemistry and Molecular Biosciences, Faculty of Science, University of Queensland, St Lucia, QLD 2072, Australia.
- 3APEX, UMR 703 PAnTher (INRAE/Oniris), 44307 Nantes, France.
- 4GVN Center of Excellence, Australian Infectious Disease Research Centre, Brisbane, QLD 4029 and 4072, Australia.
Abstract
Getah virus (GETV) is a mosquito-borne Old World alphavirus that has recently increased its geographic range, particularly in China. GETV causes rheumatic disease in horses, but in recent years its primary impact has been lethal infections in newborn piglets. Herein, we characterize a lethal Ifnar1-/- mouse model of GETV which recapitulates many of the features seen in piglets. These include lethality, high viremia, diarrhoea, and splenomegaly, with histopathological findings aligning with those seen in piglets and indicating severe, acute, multi-organ inflammatory immunopathology. RNA-Seq of spleens from GETV-infected Ifnar1-/- mice and subsequent bioinformatic analyses illustrated a cytokine storm response that included robust type I interferon signatures and a pattern of cytokine/chemokine signatures indicative of viral sepsis/septic shock. Ifnar1-/-mice thus offer a framework and a mouse model for understanding GETV disease in piglets. This model also suggests that viral sepsis/septic shock may be the cause of lethality in GETV-infected piglets.
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BibTeX
@article{bishop2026lethal,
title = {{Lethal Viral Sepsis/Septic Shock in Getah Virus-Infected Ifnar1-/- Mice.}},
author = {Cameron R Bishop and Bing Tang and Daniel J Rawle and Thibaut Larcher and Andreas Suhrbier},
journal = {Pathogens (Basel, Switzerland)},
year = {2026},
month = oct,
doi = {10.3390/pathogens15101079},
url = {https://europepmc.org/article/MED/42931232},
note = {CC BY},
}
RIS
TY - JOUR
TI - Lethal Viral Sepsis/Septic Shock in Getah Virus-Infected Ifnar1-/- Mice.
AU - Cameron R Bishop
AU - Bing Tang
AU - Daniel J Rawle
AU - Thibaut Larcher
AU - Andreas Suhrbier
PY - 2026
DA - 2026/10/14
JO - Pathogens (Basel, Switzerland)
DO - 10.3390/pathogens15101079
UR - https://europepmc.org/article/MED/42931232
AB - Getah virus (GETV) is a mosquito-borne Old World alphavirus that has recently increased its geographic range, particularly in China. GETV causes rheumatic disease in horses, but in recent years its primary impact has been lethal infections in newborn piglets. Herein, we characterize a lethal Ifnar1-/- mouse model of GETV which recapitulates many of the features seen in piglets. These include lethality, high viremia, diarrhoea, and splenomegaly, with histopathological findings aligning with those seen in piglets and indicating severe, acute, multi-organ inflammatory immunopathology. RNA-Seq of spleens from GETV-infected Ifnar1-/- mice and subsequent bioinformatic analyses illustrated a cytokine storm response that included robust type I interferon signatures and a pattern of cytokine/chemokine signatures indicative of viral sepsis/septic shock. Ifnar1-/-mice thus offer a framework and a mouse model for understanding GETV disease in piglets. This model also suggests that viral sepsis/septic shock may be the cause of lethality in GETV-infected piglets.
SN - 2076-0817
ER -