Exploring the trajectory of quality-of-life deterioration associated with capecitabine-induced hand-foot syndrome and the optimal timing for rehabilitation intervention: secondary analysis of a randomized controlled trial
Abstract
ObjectiveTo investigate the dynamic progression and key turning points of quality-of-life (QoL) impairment in patients with capecitabine-induced hand-foot syndrome (HFS) and identify the optimal timing for rehabilitation intervention.MethodsThis secondary analysis included 234 breast cancer patients receiving capecitabine from a multicenter, double-blind randomized controlled trial. HFS-related QoL (HF-QoL), EORTC QLQ-C30, and QLQ-BR23 were assessed longitudinally. Generalized estimating equations examined HFS grade-by-time interactions, and clinically significant deterioration was defined using the minimum clinically important difference (MCID ≥10 points).ResultsSignificant HFS grade-by-time interactions were observed for HF-QoL (β=1.215, 95% CI = [0.689, 1.741], P < 0.001), QLQ-C30 (β=1.464, 95% CI = [0.820, 2.109], P < 0.001), and QLQ-BR23 (β=0.451, 95% CI = [0.148,0.753], P = 0.004), indicating accelerated QoL deterioration with increasing HFS severity. The proportion of patients with clinically significant HF-QoL deterioration increased sharply from Grade 1 to Grade 2 (18.9% vs. 41.9%; OR = 3.053, P = 0.010).ConclusionHFS severity and QoL deterioration show divergent trajectories; Grade 2 may represent a critical threshold at which QoL impairment crosses the threshold of clinical significance; progression from HFS Grade 1 to Grade 2 may be a potential time point for validation in future prospective rehabilitation intervention studies.
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BibTeX
@article{wang2026exploring,
title = {{Exploring the trajectory of quality-of-life deterioration associated with capecitabine-induced hand-foot syndrome and the optimal timing for rehabilitation intervention: secondary analysis of a randomized controlled trial}},
author = {Yujing Wang and Weilin Yin and Jie Zhang and Yifan Lin and Jie Jia},
journal = {Frontiers in Oncology},
year = {2026},
month = nov,
doi = {10.3389/fonc.2026.1988890},
url = {https://www.frontiersin.org/articles/10.3389/fonc.2026.1988890},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Exploring the trajectory of quality-of-life deterioration associated with capecitabine-induced hand-foot syndrome and the optimal timing for rehabilitation intervention: secondary analysis of a randomized controlled trial
AU - Yujing Wang
AU - Weilin Yin
AU - Jie Zhang
AU - Yifan Lin
AU - Jie Jia
PY - 2026
DA - 2026/11/12
JO - Frontiers in Oncology
DO - 10.3389/fonc.2026.1988890
UR - https://www.frontiersin.org/articles/10.3389/fonc.2026.1988890
AB - ObjectiveTo investigate the dynamic progression and key turning points of quality-of-life (QoL) impairment in patients with capecitabine-induced hand-foot syndrome (HFS) and identify the optimal timing for rehabilitation intervention.MethodsThis secondary analysis included 234 breast cancer patients receiving capecitabine from a multicenter, double-blind randomized controlled trial. HFS-related QoL (HF-QoL), EORTC QLQ-C30, and QLQ-BR23 were assessed longitudinally. Generalized estimating equations examined HFS grade-by-time interactions, and clinically significant deterioration was defined using the minimum clinically important difference (MCID ≥10 points).ResultsSignificant HFS grade-by-time interactions were observed for HF-QoL (β=1.215, 95% CI = [0.689, 1.741], P < 0.001), QLQ-C30 (β=1.464, 95% CI = [0.820, 2.109], P < 0.001), and QLQ-BR23 (β=0.451, 95% CI = [0.148,0.753], P = 0.004), indicating accelerated QoL deterioration with increasing HFS severity. The proportion of patients with clinically significant HF-QoL deterioration increased sharply from Grade 1 to Grade 2 (18.9% vs. 41.9%; OR = 3.053, P = 0.010).ConclusionHFS severity and QoL deterioration show divergent trajectories; Grade 2 may represent a critical threshold at which QoL impairment crosses the threshold of clinical significance; progression from HFS Grade 1 to Grade 2 may be a potential time point for validation in future prospective rehabilitation intervention studies.
SN - 2234-943X
ER -