Convergent Amino-Acid Substitutions Link Primate Longevity to Male-Fertility Genes
- 1Institute of Evolutionary Biology (IBE, UPF-CSIC), Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona (P
Abstract
Maximum lifespan varies widely among mammals, but the genomic basis of this variation remains incompletely understood. We used body-mass-corrected longevity and a phylogenetically informed phenotype-shift framework to compare 126 primate species, selecting seven long-lived and six short-lived species for convergent amino-acid substitution analysis. Stringent pooling across species identified 1,068 recurrent phenotype-associated positions in 934 genes. These genes showed significant agreement with mammal-wide longevity candidates, with 226 genes shared compared with 120 expected by chance (1.88-fold enrichment; P = 1.16 x 10exp-22). Functional analysis detected 17 significant terms, with the strongest coherent signal involving male infertility and decreased male fertility. Our results show that focused primate sampling recovers a non-random component of the broader mammalian longevity signal and point to male reproductive biology as a promising direction for investigating the evolution of lifespan.
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BibTeX
@misc{barteri2026convergent,
title = {{Convergent Amino-Acid Substitutions Link Primate Longevity to Male-Fertility Genes}},
author = {F. Barteri and M. Ramon and E. Brigos and D. Juan and G. Muntane and A. Navarro},
howpublished = {bioRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.04.749475},
url = {https://www.biorxiv.org/content/10.64898/2026.09.04.749475v1},
note = {CC BY},
}
RIS
TY - UNPB
TI - Convergent Amino-Acid Substitutions Link Primate Longevity to Male-Fertility Genes
AU - F. Barteri
AU - M. Ramon
AU - E. Brigos
AU - D. Juan
AU - G. Muntane
AU - A. Navarro
PY - 2026
DA - 2026/09/04
PB - bioRxiv
DO - 10.64898/2026.09.04.749475
UR - https://www.biorxiv.org/content/10.64898/2026.09.04.749475v1
AB - Maximum lifespan varies widely among mammals, but the genomic basis of this variation remains incompletely understood. We used body-mass-corrected longevity and a phylogenetically informed phenotype-shift framework to compare 126 primate species, selecting seven long-lived and six short-lived species for convergent amino-acid substitution analysis. Stringent pooling across species identified 1,068 recurrent phenotype-associated positions in 934 genes. These genes showed significant agreement with mammal-wide longevity candidates, with 226 genes shared compared with 120 expected by chance (1.88-fold enrichment; P = 1.16 x 10exp-22). Functional analysis detected 17 significant terms, with the strongest coherent signal involving male infertility and decreased male fertility. Our results show that focused primate sampling recovers a non-random component of the broader mammalian longevity signal and point to male reproductive biology as a promising direction for investigating the evolution of lifespan.
ER -