Intervention with Exogenous Melatonin Has No Adverse Effects on Cardiometabolic Parameters of Overweight Night Workers without Cardiometabolic Abnormalities.
7 affiliations
- 1Pharmacy Department, Hospital Municipal de Cubatão, Cubatão, SPBrazil.
- 2Teaching and Research Laboratory, Sociedade Brasileira Caminho de Damasco, São Paulo, SPBrazil.
- 3Independent Research, São Paulo, SPBrazil.
- 4Department of Physiology, Intituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SPBrazil.
- 5Department of Health, Life Cycles, and Society, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, SPBrazil.
- 6Stress Research Institute, University of Stockholm, StockholmSweden.
- 7Department of Public Health, Post-Graduate Program in Public Health, Escola de Saúde, Universidade Federal do Rio Grande do Norte, Natal, RNBrazil.
Abstract
Night workers are chronically exposed to circadian disruption and melatonin suppression, conditions associated with an increased risk of cardiometabolic disorders. To determine whether exogenous melatonin administration impacts cardiometabolic parameters (glucose, glycated hemoglobin [HbA1c], insulin, total cholesterol, high-density lipoprotein [HDL], low-density lipoprotein [LDL], very low-density lipoprotein [VLDL], triglycerides, heart rates, and mean systolic and diastolic blood pressure) in overweight night workers without cardiometabolic abnormalities. A randomized, double-blind, placebo-controlled, crossover trial was conducted. Participants (n = 27) took 3 mg of fast-release melatonin or placebo orally for 3 months, 1 hour before bedtime, only on days off when they had nocturnal sleep, on an intermittent basis (every other day). Generalized estimating equations (GEEs) were used to analyze the cardiometabolic parameters. Systolic blood pressure showed a significant effect of time ( p = 0.01). Bonferroni-adjusted post-hoc comparisons showed higher values after placebo than at baseline (mean difference: 5.82 mmHg; 95%CI: 2.02-9.62; adjusted p = 0.01), whereas the difference between melatonin and placebo was not statistically significant (adjusted p = 1.00). No statistically significant effects of time were detected for the other cardiometabolic parameters. Melatonin was not associated with significant changes in cardiometabolic parameters compared with placebo in overweight night workers.
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BibTeX
@article{santana2026intervention,
title = {{Intervention with Exogenous Melatonin Has No Adverse Effects on Cardiometabolic Parameters of Overweight Night Workers without Cardiometabolic Abnormalities.}},
author = {Patrícia Teixeira de Santana and Adriana de Sousa Duarte and Ananda Laís Felix Garrido and Pollyanna Pellegrino and Luciana Fidalgo Ramos Nogueira and José Cipolla-Neto and Claudia Roberta de Castro Moreno and Elaine Cristina Marqueze},
journal = {Sleep science (Sao Paulo, Brazil)},
year = {2026},
month = sep,
doi = {10.1055/s-0046-1829852},
url = {https://europepmc.org/article/MED/42997745},
note = {CC BY},
}
RIS
TY - JOUR
TI - Intervention with Exogenous Melatonin Has No Adverse Effects on Cardiometabolic Parameters of Overweight Night Workers without Cardiometabolic Abnormalities.
AU - Patrícia Teixeira de Santana
AU - Adriana de Sousa Duarte
AU - Ananda Laís Felix Garrido
AU - Pollyanna Pellegrino
AU - Luciana Fidalgo Ramos Nogueira
AU - José Cipolla-Neto
AU - Claudia Roberta de Castro Moreno
AU - Elaine Cristina Marqueze
PY - 2026
DA - 2026/09/01
JO - Sleep science (Sao Paulo, Brazil)
DO - 10.1055/s-0046-1829852
UR - https://europepmc.org/article/MED/42997745
AB - Night workers are chronically exposed to circadian disruption and melatonin suppression, conditions associated with an increased risk of cardiometabolic disorders. To determine whether exogenous melatonin administration impacts cardiometabolic parameters (glucose, glycated hemoglobin [HbA1c], insulin, total cholesterol, high-density lipoprotein [HDL], low-density lipoprotein [LDL], very low-density lipoprotein [VLDL], triglycerides, heart rates, and mean systolic and diastolic blood pressure) in overweight night workers without cardiometabolic abnormalities. A randomized, double-blind, placebo-controlled, crossover trial was conducted. Participants (n = 27) took 3 mg of fast-release melatonin or placebo orally for 3 months, 1 hour before bedtime, only on days off when they had nocturnal sleep, on an intermittent basis (every other day). Generalized estimating equations (GEEs) were used to analyze the cardiometabolic parameters. Systolic blood pressure showed a significant effect of time ( p = 0.01). Bonferroni-adjusted post-hoc comparisons showed higher values after placebo than at baseline (mean difference: 5.82 mmHg; 95%CI: 2.02-9.62; adjusted p = 0.01), whereas the difference between melatonin and placebo was not statistically significant (adjusted p = 1.00). No statistically significant effects of time were detected for the other cardiometabolic parameters. Melatonin was not associated with significant changes in cardiometabolic parameters compared with placebo in overweight night workers.
SN - 1984-0659
SN - 1984-0063
ER -