Metabolic RNA Labeling: Adding a Temporal Dimension to Transcriptomics and Epitranscriptomics Analysis.
- 1School of Life Sciences, Xiamen University, Xiamen 361005, China.
- 2Institute of Molecular Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 200120, China.
Abstract
Transcriptomics and epitranscriptomics analyses have provided unprecedented insights into the transcriptome-wide RNA abundance and the post-transcriptional modifications of RNA across diverse biological processes. However, conventional transcriptomics and epitranscriptomics analyses only capture static snapshots and lack temporal resolution. To address this limitation, recent advances have integrated metabolic RNA labeling with transcriptomics and epitranscriptomics analyses, enabling time-resolved analysis of the transcription and RNA modification dynamics. This Perspective aims to highlight the recent developments and the ongoing trends in metabolic RNA labeling-based chemical tools that enable time-resolved transcriptomics and epitranscriptomics analysis. Our perspectives on current limitations and future directions are also provided, with the aim of inspiring more advanced chemical tools for accurate measurement and a deeper understanding of transcription and RNA modification dynamics in health and disease.
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BibTeX
@article{wang2026metabolic,
title = {{Metabolic RNA Labeling: Adding a Temporal Dimension to Transcriptomics and Epitranscriptomics Analysis.}},
author = {Di Wang and Zhenzhen Zhang and Shichao Lin and Chaoyong Yang},
journal = {ACS measurement science au},
year = {2026},
month = aug,
doi = {10.1021/acsmeasuresciau.6c00200},
url = {https://europepmc.org/article/MED/42921106},
note = {CC BY},
}
RIS
TY - JOUR
TI - Metabolic RNA Labeling: Adding a Temporal Dimension to Transcriptomics and Epitranscriptomics Analysis.
AU - Di Wang
AU - Zhenzhen Zhang
AU - Shichao Lin
AU - Chaoyong Yang
PY - 2026
DA - 2026/08/10
JO - ACS measurement science au
DO - 10.1021/acsmeasuresciau.6c00200
UR - https://europepmc.org/article/MED/42921106
AB - Transcriptomics and epitranscriptomics analyses have provided unprecedented insights into the transcriptome-wide RNA abundance and the post-transcriptional modifications of RNA across diverse biological processes. However, conventional transcriptomics and epitranscriptomics analyses only capture static snapshots and lack temporal resolution. To address this limitation, recent advances have integrated metabolic RNA labeling with transcriptomics and epitranscriptomics analyses, enabling time-resolved analysis of the transcription and RNA modification dynamics. This Perspective aims to highlight the recent developments and the ongoing trends in metabolic RNA labeling-based chemical tools that enable time-resolved transcriptomics and epitranscriptomics analysis. Our perspectives on current limitations and future directions are also provided, with the aim of inspiring more advanced chemical tools for accurate measurement and a deeper understanding of transcription and RNA modification dynamics in health and disease.
SN - 2694-250X
ER -