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Peer-reviewedCC BY 4.0PLOS One

Impact of revised antral follicle count threshold on PCOS diagnosis: A comparative clinical study

  • Saloni Kamboj1
  • Neena Malhotra2
  • Reeta Mahey3
  • Taruna Arora
  • Aditi Goyal
  • Snigdha Soni
  • Anshu Jyoti
  • Spondita Banerjee
  • Rintu Kutum
  1. 1Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, Delhi, India
  2. 2Division of Reproductive Biology, Maternal and Child Health, Indian Council of Medical Research, New Delhi, Delhi, India
  3. 3Department of Computer Science, Ashoka University, Sonipat, Haryana, India
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Abstract

Objective: To evaluate the clinical impact of the revised antral follicle count (AFC) threshold on polycystic ovary syndrome (PCOS) diagnosis. Methods: A retrospective cross-sectional observational study including women diagnosed using the Rotterdam criteria, stratified by AFC: 12–19 (low AFC) and ≥20 (high AFC). Clinical, metabolic, and hormonal parameters were compared against controls and amongst low and high AFC group. Results: Of 336 PCOS women, 208 (62%) had an AFC between 12 and 19 and would not meet the revised ≥20 follicle threshold for the diagnosis of polycystic morphology. These women had worse metabolic and androgenic profiles than controls, and were similar to the high AFC group. Conclusion: Excluding low AFC women may misclassify patients who require clinical care.

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Cite

BibTeXRIS
BibTeX
@article{kamboj2026impact,
  title = {{Impact of revised antral follicle count threshold on PCOS diagnosis: A comparative clinical study}},
  author = {Saloni Kamboj and Neena Malhotra and Reeta Mahey and Taruna Arora and Aditi Goyal and Snigdha Soni and Anshu Jyoti and Spondita Banerjee and Rintu Kutum},
  journal = {PLOS One},
  year = {2026},
  month = oct,
  doi = {10.1371/journal.pone.0358554},
  url = {https://doi.org/10.1371/journal.pone.0358554},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Impact of revised antral follicle count threshold on PCOS diagnosis: A comparative clinical study
AU  - Saloni Kamboj
AU  - Neena Malhotra
AU  - Reeta Mahey
AU  - Taruna Arora
AU  - Aditi Goyal
AU  - Snigdha Soni
AU  - Anshu Jyoti
AU  - Spondita Banerjee
AU  - Rintu Kutum
PY  - 2026
DA  - 2026/10/15
JO  - PLOS One
DO  - 10.1371/journal.pone.0358554
UR  - https://doi.org/10.1371/journal.pone.0358554
AB  - Objective: To evaluate the clinical impact of the revised antral follicle count (AFC) threshold on polycystic ovary syndrome (PCOS) diagnosis. Methods: A retrospective cross-sectional observational study including women diagnosed using the Rotterdam criteria, stratified by AFC: 12–19 (low AFC) and ≥20 (high AFC). Clinical, metabolic, and hormonal parameters were compared against controls and amongst low and high AFC group. Results: Of 336 PCOS women, 208 (62%) had an AFC between 12 and 19 and would not meet the revised ≥20 follicle threshold for the diagnosis of polycystic morphology. These women had worse metabolic and androgenic profiles than controls, and were similar to the high AFC group. Conclusion: Excluding low AFC women may misclassify patients who require clinical care.
SN  - 1932-6203
ER  -