Development and Assessment of a Zingiber officinale -based Biologic Dressing for Enhanced Wound Healing in Diabetic Rats
Abstract
Diabetic patients exhibit delayed skin wound healing due to chronic hyperglycemia, which results in prolonged tissue recovery. In this work, a skin dressing was synthesized using three natural composites: chitosan, gelatin, and Zingiber officinale herb, commonly known as ginger (CH+GE+ZO). The dressing was applied to albino Wistar rats, which then received an intraperitoneal injection of Alloxan at a dose of 150 mg/kg. Incision caused skin wounds. The antioxidant markers were quantified. A histological study was conducted to evaluate the effectiveness of the skin healing process. Analysis of the oxidative balance revealed a significant (p < .001) increase in enzymatic antioxidant activities in the CH+GE+ZO-treated group compared to the diabetic group. A considerable increase in non-enzymatic markers was observed compared to the diabetic group (p < .001). Histologically, the application of a composite synthesized by CH+GE+ZO dressing showed an improvement in the healing process, compared to controls, and a total recovery of wounds was observed around Day 13. This was characterized by a progressive reepithelialization, a structured organization of the layers of the epidermis, as well as a partial restoration of the cutaneous appendages. Overall, the synthesized biological dressing actively contributes to tissue repair and skin healing.
Related
- Cadmium Exposure Modulates Quality of the Medicinal Plant Dendrobium officinale via Regulation of Gene Expression, Antioxidant Systems, Bioactive Compound Accumulation, and Rhizosphere Microbial Community
- A haplotype-resolved triploid genome assembly of Zingiber striolatum sheds light on genome expansion and trait evolution in Zingiberaceae
- Characterization of the First Complete Plastome of Zingiber emeiense : Insights Into Its Phylogenetic Position
- The Structure, Evolution, and Comparative Genomics of the Dendrobium officinale Mitochondrial Genome.
- Community Needs Assessment for Bamboo Marinduque: A Strategic Framework for Community-Led Bamboo Development and Engagement
BibTeX
@article{ghabbari2026development,
title = {{Development and Assessment of a Zingiber officinale -based Biologic Dressing for Enhanced Wound Healing in Diabetic Rats}},
author = {Mabrouka Ghabbari and Awatef Elwej and Taysir Ghabbari and Ghada Ben Salah and Amal Ahmed Ismail and Hassane Oudadesse and Samira Jebahi},
journal = {Journal of Applied Pharmaceutical Science},
year = {2026},
month = oct,
doi = {10.1177/22313354261438281},
url = {https://hal.science/hal-05834638v1},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Development and Assessment of a Zingiber officinale -based Biologic Dressing for Enhanced Wound Healing in Diabetic Rats
AU - Mabrouka Ghabbari
AU - Awatef Elwej
AU - Taysir Ghabbari
AU - Ghada Ben Salah
AU - Amal Ahmed Ismail
AU - Hassane Oudadesse
AU - Samira Jebahi
PY - 2026
DA - 2026/10/22
JO - Journal of Applied Pharmaceutical Science
DO - 10.1177/22313354261438281
UR - https://hal.science/hal-05834638v1
AB - Diabetic patients exhibit delayed skin wound healing due to chronic hyperglycemia, which results in prolonged tissue recovery. In this work, a skin dressing was synthesized using three natural composites: chitosan, gelatin, and Zingiber officinale herb, commonly known as ginger (CH+GE+ZO). The dressing was applied to albino Wistar rats, which then received an intraperitoneal injection of Alloxan at a dose of 150 mg/kg. Incision caused skin wounds. The antioxidant markers were quantified. A histological study was conducted to evaluate the effectiveness of the skin healing process. Analysis of the oxidative balance revealed a significant (p < .001) increase in enzymatic antioxidant activities in the CH+GE+ZO-treated group compared to the diabetic group. A considerable increase in non-enzymatic markers was observed compared to the diabetic group (p < .001). Histologically, the application of a composite synthesized by CH+GE+ZO dressing showed an improvement in the healing process, compared to controls, and a total recovery of wounds was observed around Day 13. This was characterized by a progressive reepithelialization, a structured organization of the layers of the epidermis, as well as a partial restoration of the cutaneous appendages. Overall, the synthesized biological dressing actively contributes to tissue repair and skin healing.
SN - 2231-3354
ER -