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Patterns of perceptions and beliefs about PrEP and their association with daily oral PrEP initiation among sexual and gender diverse adolescents in Brazil Padrões de percepções e crenças sobre a PrEP e sua associação com o início da PrEP oral diária entre adolescentes com diversidade sexual e de gênero no Brasil Patrones de percepciones y creencias sobre PrEP y su asociación con el inicio de la PrEP oral diaria entre adolescentes sexual y genéricamente diversos en Brasil

  • Suelen Seixas1
  • Nila Galvão2
  • Beo Oliveira Leite3
  • Fabiane Soares3
  • Leila Denise Alves Ferreira Amorim4
  • Jony A. Pinto5
  • Eliana Miura Zucchi6,7
  • Dirceu B. Greco8
  • Alexandre Grangeiro9
  • Inês Dourado3
  • Laio Magno1,3,10
10 affiliations
  1. 1Departamento de Ciências da Vida, Universidade do Estado da Bahia, Salvador, Brasil.
  2. 2Departamento de Ciências Exatas e da Terra, Universidade do Estado da Bahia, Salvador, Brasil.
  3. 3Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, Brasil.
  4. 4Departamento de Estatística, Universidade Federal da Bahia, Salvador, Brasil.
  5. 5Departamento de Estatística, Universidade Federal Fluminense, Niterói, Brasil.
  6. 6Universidade Católica de Santos, Santos, Brasil.
  7. 7Faculdade Israelita de Ciências da Saúde Albert Einstein, São Paulo, Brasil.
  8. 8Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
  9. 9Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brasil.
  10. 10Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Fiocruz, Salvador Brasil.
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Abstract

Perceptions and beliefs about pre-exposure prophylaxis (PrEP) for HIV are shaped by various factors and play a key role in its uptake. This study analyzed the relationship between these perceptions and PrEP initiation among adolescent men who have sex with men (AMSM) and adolescent transgender women (ATGW) in Brazil. This cross-sectional analysis used baseline data from the PrEP15-19 study, which evaluated the effectiveness of daily oral PrEP among AMSM and ATGW aged 15-19 years in three Brazilian cities from February 2019 to February 2023. Latent class analysis (LCA) was employed to identify patterns in PrEP-related perceptions and beliefs based on eight binary (agree/disagree) indicators. Logistic regression was used to estimate adjusted odds ratios (adjORs) for the association between these patterns of perceptions and beliefs and PrEP initiation. A total of 1,477 adolescents were included in the analysis, the majority of whom were AMSM (91%) and aged 18-19 years (74.5%). Most participants identified as Black or Mixed-race (72%), and 81.4% initiated PrEP within 30 days of their initial study visit. LCA revealed two distinct groups based on perceptions and beliefs about PrEP: positive (n = 1,348; 93.2%) and negative (n = 99; 6.8%). Adolescents with positive perceptions and beliefs were significantly more likely to initiate PrEP (adjOR = 1.73; 95%CI: 1.05-2.84). Most participants held positive perceptions and beliefs about PrEP, which were strongly associated with timely initiation. These findings highlight the importance of addressing individual perceptions and beliefs and providing accurate, accessible information about PrEP. Educational interventions are essential to further improve PrEP awareness and uptake among vulnerable adolescent populations.

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Cite

BibTeXRIS
BibTeX
@article{seixas2026patterns,
  title = {{Patterns of perceptions and beliefs about PrEP and their association with daily oral PrEP initiation among sexual and gender diverse adolescents in Brazil Padrões de percepções e crenças sobre a PrEP e sua associação com o início da PrEP oral diária entre adolescentes com diversidade sexual e de gênero no Brasil Patrones de percepciones y creencias sobre PrEP y su asociación con el inicio de la PrEP oral diaria entre adolescentes sexual y genéricamente diversos en Brasil}},
  author = {Suelen Seixas and Nila Galvão and Beo Oliveira Leite and Fabiane Soares and Leila Denise Alves Ferreira Amorim and Jony A. Pinto and Eliana Miura Zucchi and Dirceu B. Greco and Alexandre Grangeiro and Inês Dourado and Laio Magno},
  journal = {Cadernos de saude publica},
  year = {2026},
  month = oct,
  doi = {10.1590/0102-311xen202725},
  url = {https://europepmc.org/article/PMC/PMC13722035},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Patterns of perceptions and beliefs about PrEP and their association with daily oral PrEP initiation among sexual and gender diverse adolescents in Brazil Padrões de percepções e crenças sobre a PrEP e sua associação com o início da PrEP oral diária entre adolescentes com diversidade sexual e de gênero no Brasil Patrones de percepciones y creencias sobre PrEP y su asociación con el inicio de la PrEP oral diaria entre adolescentes sexual y genéricamente diversos en Brasil
AU  - Suelen Seixas
AU  - Nila Galvão
AU  - Beo Oliveira Leite
AU  - Fabiane Soares
AU  - Leila Denise Alves Ferreira Amorim
AU  - Jony A. Pinto
AU  - Eliana Miura Zucchi
AU  - Dirceu B. Greco
AU  - Alexandre Grangeiro
AU  - Inês Dourado
AU  - Laio Magno
PY  - 2026
DA  - 2026/10/30
JO  - Cadernos de saude publica
DO  - 10.1590/0102-311xen202725
UR  - https://europepmc.org/article/PMC/PMC13722035
AB  - Perceptions and beliefs about pre-exposure prophylaxis (PrEP) for HIV are shaped by various factors and play a key role in its uptake. This study analyzed the relationship between these perceptions and PrEP initiation among adolescent men who have sex with men (AMSM) and adolescent transgender women (ATGW) in Brazil. This cross-sectional analysis used baseline data from the PrEP15-19 study, which evaluated the effectiveness of daily oral PrEP among AMSM and ATGW aged 15-19 years in three Brazilian cities from February 2019 to February 2023. Latent class analysis (LCA) was employed to identify patterns in PrEP-related perceptions and beliefs based on eight binary (agree/disagree) indicators. Logistic regression was used to estimate adjusted odds ratios (adjORs) for the association between these patterns of perceptions and beliefs and PrEP initiation. A total of 1,477 adolescents were included in the analysis, the majority of whom were AMSM (91%) and aged 18-19 years (74.5%). Most participants identified as Black or Mixed-race (72%), and 81.4% initiated PrEP within 30 days of their initial study visit. LCA revealed two distinct groups based on perceptions and beliefs about PrEP: positive (n = 1,348; 93.2%) and negative (n = 99; 6.8%). Adolescents with positive perceptions and beliefs were significantly more likely to initiate PrEP (adjOR = 1.73; 95%CI: 1.05-2.84). Most participants held positive perceptions and beliefs about PrEP, which were strongly associated with timely initiation. These findings highlight the importance of addressing individual perceptions and beliefs and providing accurate, accessible information about PrEP. Educational interventions are essential to further improve PrEP awareness and uptake among vulnerable adolescent populations.
SN  - 0102-311X
SN  - 1678-4464
ER  -