Spatially or temporally resolved phase-based optoretinography with actively-tracked point-scanning optical coherence tomography
Abstract
Optoretinography is a promising approach to measure visual function but its clinical translation has remained confined to research settings due to demanding hardware requirements. Here, we demonstrate that high-quality phase-based optoretinography can be performed using conventional point-scanning spectral-domain optical coherence tomography. We show that the need for high imaging speed can be circumvented by accurate sampling of phase changes at consistent spatial location. Light-evoked outer-segment expansion could be temporally resolved in B-scan series acquired at a fixed position when filtering off-location B-scans, and spatially resolved in volumes acquired at rates as low as 1~Hz. These results indicate that the technical barrier for phase-based optoretinography is substantially lower than previously assumed and pave the way toward broad clinical translation.
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BibTeX
@misc{puyo2026spatially,
title = {{Spatially or temporally resolved phase-based optoretinography with actively-tracked point-scanning optical coherence tomography}},
author = {Léo Puyo and Jonas Franke and Felix Zeisberger and Roland Rocholz and Gereon Hüttmann},
howpublished = {arXiv},
year = {2026},
month = aug,
doi = {10.48550/arxiv.2608.30411},
eprint = {2608.30411},
archivePrefix = {arXiv},
url = {https://arxiv.org/abs/2608.30411},
}
RIS
TY - UNPB
TI - Spatially or temporally resolved phase-based optoretinography with actively-tracked point-scanning optical coherence tomography
AU - Léo Puyo
AU - Jonas Franke
AU - Felix Zeisberger
AU - Roland Rocholz
AU - Gereon Hüttmann
PY - 2026
DA - 2026/08/31
PB - arXiv
DO - 10.48550/arxiv.2608.30411
UR - https://arxiv.org/abs/2608.30411
AB - Optoretinography is a promising approach to measure visual function but its clinical translation has remained confined to research settings due to demanding hardware requirements. Here, we demonstrate that high-quality phase-based optoretinography can be performed using conventional point-scanning spectral-domain optical coherence tomography. We show that the need for high imaging speed can be circumvented by accurate sampling of phase changes at consistent spatial location. Light-evoked outer-segment expansion could be temporally resolved in B-scan series acquired at a fixed position when filtering off-location B-scans, and spatially resolved in volumes acquired at rates as low as 1~Hz. These results indicate that the technical barrier for phase-based optoretinography is substantially lower than previously assumed and pave the way toward broad clinical translation.
ER -