Fabrication and Characterization of Chitosan-Integrated Polyvinyl Alcohol–Polycaprolactone/Tea Tree Oil Nanofibrous Scaffolds via Dual-Nozzle Electrospinning for Wound Dressing Applications
5 affiliations
- 1Chemical Engineering Department, Engineering Faculty, Istanbul University Cerrahpasa, Istanbul 34320, Turkey
- 2Department of Metallurgical and Materials Engineering, Faculty of Technology, Marmara University, Istanbul 34722, Turkey
- 3Department of Biophysics, Faculty of Medicine, Istanbul Arel University, Istanbul 34010, Turkey
- 4Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istanbul Atlas University, Istanbul 34403, Turkey
- 5Atlas University Research Center (ARC), Istanbul Atlas University, Istanbul 34403, Turkey
Abstract
Hybrid nanofibrous mats comprising distinct hydrophilic and hydrophobic fiber populations were fabricated by simultaneous dual-nozzle co-electrospinning for potential wound-dressing applications. Four formulations—polyvinyl alcohol (PVA)–polycaprolactone (PCL), PVA/Chitosan (CS)–PCL, PVA-PCL/Tea Tree Oil (TTO), and PVA/CS-PCL/TTO—were systematically evaluated in terms of their morphological, physicochemical, mechanical, release, and in vitro cellular properties. All formulations exhibited continuous, bead-free fiber morphologies. FTIR and DSC analyses indicated the physical incorporation of CS and TTO and composition-dependent changes in polymer-chain organization. TTO incorporation improved surface wettability, decreasing the water contact angle to 46.69 ± 2.80° and 57.05 ± 1.40° in the CS-free and CS-containing formulations, respectively. The PVA/CS-PCL/TTO mat exhibited the highest tensile strength (19.17 ± 3.06 MPa) and strain at break (10.82 ± 1.81%). Cumulative TTO release reached 97.63–99.75% within 8 h. MTT analysis showed favorable HDF metabolic activity, with the highest response observed for PVA/CS-PCL/TTO on day 7. Overall, the results support the further investigation of these hybrid nanofibrous mats as potential wound-dressing platforms.
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BibTeX
@article{ismayilova2026fabrication,
title = {{Fabrication and Characterization of Chitosan-Integrated Polyvinyl Alcohol–Polycaprolactone/Tea Tree Oil Nanofibrous Scaffolds via Dual-Nozzle Electrospinning for Wound Dressing Applications}},
author = {Natavan Ismayilova and Tubanur Avci and Zekiye Akdag and Ridvan Yildirim and Zehra Kanli and Ahmet Akif Kızılkurtlu and Oguzhan Gunduz and Canan Dogan},
journal = {Polymers},
year = {2026},
month = oct,
doi = {10.3390/polym18202558},
url = {https://www.mdpi.com/2073-4360/18/20/2558},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Fabrication and Characterization of Chitosan-Integrated Polyvinyl Alcohol–Polycaprolactone/Tea Tree Oil Nanofibrous Scaffolds via Dual-Nozzle Electrospinning for Wound Dressing Applications
AU - Natavan Ismayilova
AU - Tubanur Avci
AU - Zekiye Akdag
AU - Ridvan Yildirim
AU - Zehra Kanli
AU - Ahmet Akif Kızılkurtlu
AU - Oguzhan Gunduz
AU - Canan Dogan
PY - 2026
DA - 2026/10/01
JO - Polymers
DO - 10.3390/polym18202558
UR - https://www.mdpi.com/2073-4360/18/20/2558
AB - Hybrid nanofibrous mats comprising distinct hydrophilic and hydrophobic fiber populations were fabricated by simultaneous dual-nozzle co-electrospinning for potential wound-dressing applications. Four formulations—polyvinyl alcohol (PVA)–polycaprolactone (PCL), PVA/Chitosan (CS)–PCL, PVA-PCL/Tea Tree Oil (TTO), and PVA/CS-PCL/TTO—were systematically evaluated in terms of their morphological, physicochemical, mechanical, release, and in vitro cellular properties. All formulations exhibited continuous, bead-free fiber morphologies. FTIR and DSC analyses indicated the physical incorporation of CS and TTO and composition-dependent changes in polymer-chain organization. TTO incorporation improved surface wettability, decreasing the water contact angle to 46.69 ± 2.80° and 57.05 ± 1.40° in the CS-free and CS-containing formulations, respectively. The PVA/CS-PCL/TTO mat exhibited the highest tensile strength (19.17 ± 3.06 MPa) and strain at break (10.82 ± 1.81%). Cumulative TTO release reached 97.63–99.75% within 8 h. MTT analysis showed favorable HDF metabolic activity, with the highest response observed for PVA/CS-PCL/TTO on day 7. Overall, the results support the further investigation of these hybrid nanofibrous mats as potential wound-dressing platforms.
SN - 2073-4360
ER -