Rates of childbirth in female cancer survivors: A population-based study in Taiwan
- 1Nursing Department, Chi Mei Medical Center, Tainan, Taiwan
- 2Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan
- 3Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital Tainan Branch, Tainan, Taiwan
Abstract
Background: As cancer survival improves, increasing numbers of women diagnosed during their reproductive years face potential fertility impairment. However, population-based evidence on post-cancer childbearing remains limited in Asian settings. Methods: We conducted a nationwide cohort study in Taiwan by linking the Cancer Registry, Birth Reporting Registry, and Death Registry. A total of 72,929 females diagnosed with cancer at age ≤ 39 years were followed to identify subsequent livebirths. The cumulative incidence of first post-diagnosis livebirth was estimated using competing-risk methods. Predictors were evaluated using cause-specific Cox models. Standardized birth ratios (SBRs) were calculated by comparing observed births with expected births in the general population, standardized by age and calendar year. Results: Overall, 9.8% of female cancer survivors had at least one livebirth after diagnosis. The 5-, 10-, and 15-year cumulative incidences were 6.4%, 10.7%, and 13.9%, respectively. Compared with the general population, survivors had approximately half the expected number of births (SBR = 0.50; 95% CI, 0.49–0.51). Substantial heterogeneity was observed across cancer types: childbirth was most preserved among survivors of thyroid and skin cancers, whereas those with cervical, uterine, breast, leukemia, and central nervous system cancers had markedly reduced childbirth. Older age at diagnosis and receipt of chemotherapy were strongly associated with lower likelihood of childbirth. Conclusions: In this large, nationwide study, female cancer survivors in Taiwan experienced substantially reduced childbirth rates, with pronounced variation by cancer type, age at diagnosis, and treatment. These findings provide robust population-level evidence from an Asian context and highlight the need for early fertility counseling and improved access to oncofertility care.
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BibTeX
@article{hsieh2026rates,
title = {{Rates of childbirth in female cancer survivors: A population-based study in Taiwan}},
author = {Ya-Ling Hsieh and Chia-Jung Chiang and Tsung Yu},
journal = {PLOS One},
year = {2026},
month = sep,
doi = {10.1371/journal.pone.0358466},
url = {https://doi.org/10.1371/journal.pone.0358466},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Rates of childbirth in female cancer survivors: A population-based study in Taiwan
AU - Ya-Ling Hsieh
AU - Chia-Jung Chiang
AU - Tsung Yu
PY - 2026
DA - 2026/09/11
JO - PLOS One
DO - 10.1371/journal.pone.0358466
UR - https://doi.org/10.1371/journal.pone.0358466
AB - Background: As cancer survival improves, increasing numbers of women diagnosed during their reproductive years face potential fertility impairment. However, population-based evidence on post-cancer childbearing remains limited in Asian settings. Methods: We conducted a nationwide cohort study in Taiwan by linking the Cancer Registry, Birth Reporting Registry, and Death Registry. A total of 72,929 females diagnosed with cancer at age ≤ 39 years were followed to identify subsequent livebirths. The cumulative incidence of first post-diagnosis livebirth was estimated using competing-risk methods. Predictors were evaluated using cause-specific Cox models. Standardized birth ratios (SBRs) were calculated by comparing observed births with expected births in the general population, standardized by age and calendar year. Results: Overall, 9.8% of female cancer survivors had at least one livebirth after diagnosis. The 5-, 10-, and 15-year cumulative incidences were 6.4%, 10.7%, and 13.9%, respectively. Compared with the general population, survivors had approximately half the expected number of births (SBR = 0.50; 95% CI, 0.49–0.51). Substantial heterogeneity was observed across cancer types: childbirth was most preserved among survivors of thyroid and skin cancers, whereas those with cervical, uterine, breast, leukemia, and central nervous system cancers had markedly reduced childbirth. Older age at diagnosis and receipt of chemotherapy were strongly associated with lower likelihood of childbirth. Conclusions: In this large, nationwide study, female cancer survivors in Taiwan experienced substantially reduced childbirth rates, with pronounced variation by cancer type, age at diagnosis, and treatment. These findings provide robust population-level evidence from an Asian context and highlight the need for early fertility counseling and improved access to oncofertility care.
SN - 1932-6203
ER -