Prevalence of Klinefelter syndrome among infertile men with spermogram abnormalities: a cross-sectional study at a referral laboratory in Rabat, Morocco.
5 affiliations
- 1Laboratory of Microbiology and Molecular Biology, Faculty of Sciences, Mohammed V University, Avenue Ibn Battouta, BP 1014, Rabat 10000, Morocco.
- 2Biolab Laboratory, Rabat, Morocco.
- 3Department of Cytogenetics, Institut Pasteur, Casablanca, Morocco.
- 4High Institute of Health Sciences, University Hassan First, Settat, Morocco.
- 5Faculty of Sciences, University Ibn Tofail, Kenitra, Morocco.
Abstract
Klinefelter syndrome (KS), the most common genetic cause of male infertility, remains vastly underdiagnosed in Morocco and across Africa due to limited cytogenetic access. we conducted a 5-year retrospective cross-sectional study (2020-2024) at BIOLAB Laboratory, Rabat, analyzing 415 infertile Moroccan men (18-58 years) with spermogram abnormalities (azoospermia or oligospermia) who were referred for karyotyping. Standard R-banding cytogenetics (≥15 metaphases; ISCN 2020) was performed on peripheral blood lymphocytes. among 415 infertile men included in the study, Klinefelter syndrome was identified in 45 cases (10.8%). The prevalence of KS was higher among azoospermic men (12.6%) compared with oligospermic men (3.1%). Most cases were non-mosaic 47, XXY (91.1%), while mosaic forms accounted for 8.9% of cases. Klinefelter syndrome was frequently observed among infertile men with severe spermogram abnormalities in this referral-based population, particularly among azoospermic patients. These findings highlight the importance of cytogenetic evaluation in infertile men presenting with azoospermia or severe oligospermia.
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BibTeX
@article{chebihi2026prevalence,
title = {{Prevalence of Klinefelter syndrome among infertile men with spermogram abnormalities: a cross-sectional study at a referral laboratory in Rabat, Morocco.}},
author = {Zahra Takki Chebihi and Elbekkay Chadli and Fatine Hadrya and Bouchra Belkadi and Aziza Belkhayat},
journal = {The Pan African medical journal},
year = {2026},
month = jun,
doi = {10.11604/pamj.2026.54.36.50134},
url = {https://europepmc.org/article/MED/42952821},
note = {CC BY},
}
RIS
TY - JOUR
TI - Prevalence of Klinefelter syndrome among infertile men with spermogram abnormalities: a cross-sectional study at a referral laboratory in Rabat, Morocco.
AU - Zahra Takki Chebihi
AU - Elbekkay Chadli
AU - Fatine Hadrya
AU - Bouchra Belkadi
AU - Aziza Belkhayat
PY - 2026
DA - 2026/06/08
JO - The Pan African medical journal
DO - 10.11604/pamj.2026.54.36.50134
UR - https://europepmc.org/article/MED/42952821
AB - Klinefelter syndrome (KS), the most common genetic cause of male infertility, remains vastly underdiagnosed in Morocco and across Africa due to limited cytogenetic access. we conducted a 5-year retrospective cross-sectional study (2020-2024) at BIOLAB Laboratory, Rabat, analyzing 415 infertile Moroccan men (18-58 years) with spermogram abnormalities (azoospermia or oligospermia) who were referred for karyotyping. Standard R-banding cytogenetics (≥15 metaphases; ISCN 2020) was performed on peripheral blood lymphocytes. among 415 infertile men included in the study, Klinefelter syndrome was identified in 45 cases (10.8%). The prevalence of KS was higher among azoospermic men (12.6%) compared with oligospermic men (3.1%). Most cases were non-mosaic 47, XXY (91.1%), while mosaic forms accounted for 8.9% of cases. Klinefelter syndrome was frequently observed among infertile men with severe spermogram abnormalities in this referral-based population, particularly among azoospermic patients. These findings highlight the importance of cytogenetic evaluation in infertile men presenting with azoospermia or severe oligospermia.
SN - 1937-8688
ER -