Knowledge, trust, and multidimensional perceptions of human papillomavirus vaccination among women attending a single primary care centre in Astana, Kazakhstan: a cross-sectional study.
- 1Department of General Medical Practice with a course in evidence-based medicine, Astana Medical University, Astana, Kazakhstan.
- 2Department of Research Institute of Preventive Medicine Named Academician E.Dalenov, Astana Medical University, Astana, Kazakhstan.
- 3Department of Science, Medical Education and Human Resources, Ministry of Healthcare of the Republic of Kazakhstan, Astana, Kazakhstan.
Abstract
Background
Kazakhstan reintroduced human papillomavirus (HPV) vaccination in 2024, making public confidence and communication important. This study described HPV knowledge and trust in information sources and exploratorily examined vaccine-perception structure and correlates among women attending primary care in Astana.Methods
A cross-sectional electronic survey was conducted from 17 January to 28 February 2026 among 221 adult women recruited through convenience sampling. HPV knowledge, source-specific trust, and 16 perception items were assessed. Exploratory psychometric analysis used polychoric correlations, parallel analysis, and principal-axis factor analysis with oblimin rotation to derive preliminary composite measures. Spearman correlations and robust multivariable linear models examined safety concern and perceived effectiveness. A secondary logistic model examined refusal or intention to refuse HPV vaccination for a daughter.Results
Mean HPV knowledge was 4.95 ± 3.84 of 12. A five-item safety concern measure (mean 2.34 ± 0.97; α = 0.868; ω = 0.901) and a three-item perceived effectiveness measure (mean 3.20 ± 1.24; α = 0.922; ω = 0.948) were derived. Knowledge correlated negatively with safety concern (ρ = -0.284, p < 0.001) and positively with perceived effectiveness (ρ = 0.393, p < 0.001). Safety concern was associated with COVID-19 controversy spillover (B = 0.190, 95% CI 0.043-0.337), earlier-programme distrust (B = 0.197, 95% CI 0.047-0.347), and preference for natural immunity (B = 0.137, 95% CI 0.040-0.234). Higher knowledge (B = 0.061, 95% CI 0.010-0.111) and professional/scientific trust (B = 0.297, 95% CI 0.114-0.480) were associated with greater perceived effectiveness. Forty-nine participants (22.2%) reported refusal or intention to refuse vaccination for a daughter; knowing someone believed to have become seriously ill after vaccination was associated with this response (aOR 7.42, 95% CI 2.60-21.16).Conclusion
HPV vaccine perceptions were multidimensional. Knowledge and professional-scientific trust were linked mainly to perceived effectiveness, whereas safety concerns were more strongly related to vaccine narratives. Communication strategies should combine factual education with transparent safety dialogue and clinician communication.
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BibTeX
@article{umbetzhanova2026knowledge,
title = {{Knowledge, trust, and multidimensional perceptions of human papillomavirus vaccination among women attending a single primary care centre in Astana, Kazakhstan: a cross-sectional study.}},
author = {Ayagyoz Umbetzhanova and Adina Kusniyeva and Gulmira Derbissalina and Aigul Abduldayeva and Nikolay Safonov and Vitaliy Koikov},
journal = {Frontiers in global women's health},
year = {2026},
month = oct,
doi = {10.3389/fgwh.2026.1960252},
url = {https://europepmc.org/article/MED/42922943},
note = {CC BY},
}
RIS
TY - JOUR
TI - Knowledge, trust, and multidimensional perceptions of human papillomavirus vaccination among women attending a single primary care centre in Astana, Kazakhstan: a cross-sectional study.
AU - Ayagyoz Umbetzhanova
AU - Adina Kusniyeva
AU - Gulmira Derbissalina
AU - Aigul Abduldayeva
AU - Nikolay Safonov
AU - Vitaliy Koikov
PY - 2026
DA - 2026/10/08
JO - Frontiers in global women's health
DO - 10.3389/fgwh.2026.1960252
UR - https://europepmc.org/article/MED/42922943
AB - Background Kazakhstan reintroduced human papillomavirus (HPV) vaccination in 2024, making public confidence and communication important. This study described HPV knowledge and trust in information sources and exploratorily examined vaccine-perception structure and correlates among women attending primary care in Astana.Methods A cross-sectional electronic survey was conducted from 17 January to 28 February 2026 among 221 adult women recruited through convenience sampling. HPV knowledge, source-specific trust, and 16 perception items were assessed. Exploratory psychometric analysis used polychoric correlations, parallel analysis, and principal-axis factor analysis with oblimin rotation to derive preliminary composite measures. Spearman correlations and robust multivariable linear models examined safety concern and perceived effectiveness. A secondary logistic model examined refusal or intention to refuse HPV vaccination for a daughter.Results Mean HPV knowledge was 4.95 ± 3.84 of 12. A five-item safety concern measure (mean 2.34 ± 0.97; α = 0.868; ω = 0.901) and a three-item perceived effectiveness measure (mean 3.20 ± 1.24; α = 0.922; ω = 0.948) were derived. Knowledge correlated negatively with safety concern (ρ = -0.284, p < 0.001) and positively with perceived effectiveness (ρ = 0.393, p < 0.001). Safety concern was associated with COVID-19 controversy spillover (B = 0.190, 95% CI 0.043-0.337), earlier-programme distrust (B = 0.197, 95% CI 0.047-0.347), and preference for natural immunity (B = 0.137, 95% CI 0.040-0.234). Higher knowledge (B = 0.061, 95% CI 0.010-0.111) and professional/scientific trust (B = 0.297, 95% CI 0.114-0.480) were associated with greater perceived effectiveness. Forty-nine participants (22.2%) reported refusal or intention to refuse vaccination for a daughter; knowing someone believed to have become seriously ill after vaccination was associated with this response (aOR 7.42, 95% CI 2.60-21.16).Conclusion HPV vaccine perceptions were multidimensional. Knowledge and professional-scientific trust were linked mainly to perceived effectiveness, whereas safety concerns were more strongly related to vaccine narratives. Communication strategies should combine factual education with transparent safety dialogue and clinician communication.
SN - 2673-5059
ER -