Status Epilepticus as the Initial Manifestation of Follicular Lymphoma with Leptomeningeal Dissemination

Abstract

Follicular lymphoma (FL) rarely presents with central nervous system involvement at the time of the diagnosis. We describe the case of a 44-year-old man who presented with meningoencephalitis and subsequently developed status epilepticus due to diffuse leptomeningeal dissemination of grade 1 FL. Cerebrospinal fluid (CSF) cytology yielded negative results, but flow cytometry detected monoclonal B-cell proliferation, leading to a diagnosis. Rapid neurological recovery was achieved after immunochemotherapy. This case underscores the importance of CSF flow cytometry in mononuclear cell-predominant meningoencephalitis that is unresponsive to empirical therapy.

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BibTeX

@article{ibukuro2026status,
  title = {{Status Epilepticus as the Initial Manifestation of Follicular Lymphoma with Leptomeningeal Dissemination}},
  author = {Momoyo Ibukuro and Kenichi Sakuta and Motohiro Okumura and Shu Fujimoto and Fumie Wada and Yuki Asahara and Tadahiro Gunji and Shiko Honma and Yasuyuki Iguchi},
  journal = {Internal Medicine},
  year = {2026},
  month = sep,
  doi = {10.2169/internalmedicine.6762-25},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/18/65_6762-25/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Status Epilepticus as the Initial Manifestation of Follicular Lymphoma with Leptomeningeal Dissemination
AU  - Momoyo Ibukuro
AU  - Kenichi Sakuta
AU  - Motohiro Okumura
AU  - Shu Fujimoto
AU  - Fumie Wada
AU  - Yuki Asahara
AU  - Tadahiro Gunji
AU  - Shiko Honma
AU  - Yasuyuki Iguchi
PY  - 2026
DA  - 2026/09/15
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.6762-25
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/65/18/65_6762-25/_article
AB  - Follicular lymphoma (FL) rarely presents with central nervous system involvement at the time of the diagnosis. We describe the case of a 44-year-old man who presented with meningoencephalitis and subsequently developed status epilepticus due to diffuse leptomeningeal dissemination of grade 1 FL. Cerebrospinal fluid (CSF) cytology yielded negative results, but flow cytometry detected monoclonal B-cell proliferation, leading to a diagnosis. Rapid neurological recovery was achieved after immunochemotherapy. This case underscores the importance of CSF flow cytometry in mononuclear cell-predominant meningoencephalitis that is unresponsive to empirical therapy.
SN  - 1349-7235
SN  - 0918-2918
ER  -

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