Impacts of Oliceridine versus Sufentanil on the Quality of Postoperative Recovery in Elective Gynecological Laparoscopic Surgery: A Randomized Controlled Trial
4 affiliations
- 1Department of Anesthesiology, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning, People’s Republic of China
- 2Graduate School, Dalian Medical University, Dalian, Liaoning, People’s Republic of China
- 3Department of Gynecology, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning, People’s Republic of China
- 4Department of Pharmacy, Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital), Dalian, Liaoning, People’s Republic of China
Abstract
Background: Oliceridine is a novel μ-opioid receptor agonist selectively activating the G protein signaling pathway. This study aimed to explore the influences of patient-controlled intravenous analgesia (PCIA) employing oliceridine and sufentanil on the postoperative recovery of patients undergoing elective laparoscopic gynecological surgery.
Methods: This study included 136 patients aged 18–65 years who were randomized to receive elective gynecological laparoscopic surgery under general anaesthesia with administering PCIA with oliceridine or sufentanil. The primary outcome was the Quality of Recovery - 15 (QoR-15) score on postoperative day 1 (POD 1). Secondary outcome measures comprised: the overall benefit of analgesic score (OBAS) on POD 1; time to first flatus; time to first ambulation; postoperative hospital stay; QoR-15 score on POD 2 and 3; PCIA total injected drugs; the number of patients requiring rescue analgesia and rescue antiemetics; VAS scores from T1 to T6, and MOAA/S scores from T1 to T5; the incidence rate of adverse events; perioperative vital signs.
Results: In the primary ITT analysis using multiple imputation (n=136), analysis of covariance adjusting for baseline QoR‑15 score showed that the group O had significantly higher QoR‑15 scores on POD 1 than the group S, with the adjusted mean difference of 11.94 points (95% CI: 10.02–13.86; p < 0.001). Statistical differences between the two groups were observed in POD 1 OBAS score, time to first flatus, time to first ambulation, hospital discharge duration, and QoR-15 scores on POD 2 and 3. In addition, compared with the sufentanil group, the oliceridine group was observed to have a lower incidence of opioid-related adverse events.
Conclusion: In this single-center study of relatively young and healthy female patients undergoing gynecologic laparoscopic surgery, oliceridine demonstrated superior recovery quality compared with sufentanil, with a between-group difference exceeding the 6-point MCID threshold. It also significantly accelerated gastrointestinal recovery, shortened hospital stay.
Trial Registration: This study was registered with the Chinese Clinical Trial Registry (ChiCTR2400090783).
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BibTeX
@article{jiang2026impacts,
title = {{Impacts of Oliceridine versus Sufentanil on the Quality of Postoperative Recovery in Elective Gynecological Laparoscopic Surgery: A Randomized Controlled Trial}},
author = {Chenxin Jiang and Ruonan Song and Di Wang and Naying Su and Yutao Chen and Siru Li and Fanchen Zhou and Zhen Yang and Yingying Jiao and Yalin Xi and Congjie Bi},
journal = {Drug Design, Development and Therapy},
year = {2026},
month = oct,
doi = {10.2147/dddt.s612360},
url = {https://doi.org/10.2147/dddt.s612360},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Impacts of Oliceridine versus Sufentanil on the Quality of Postoperative Recovery in Elective Gynecological Laparoscopic Surgery: A Randomized Controlled Trial
AU - Chenxin Jiang
AU - Ruonan Song
AU - Di Wang
AU - Naying Su
AU - Yutao Chen
AU - Siru Li
AU - Fanchen Zhou
AU - Zhen Yang
AU - Yingying Jiao
AU - Yalin Xi
AU - Congjie Bi
PY - 2026
DA - 2026/10/31
JO - Drug Design, Development and Therapy
DO - 10.2147/dddt.s612360
UR - https://doi.org/10.2147/dddt.s612360
AB - Background: Oliceridine is a novel μ-opioid receptor agonist selectively activating the G protein signaling pathway. This study aimed to explore the influences of patient-controlled intravenous analgesia (PCIA) employing oliceridine and sufentanil on the postoperative recovery of patients undergoing elective laparoscopic gynecological surgery. Methods: This study included 136 patients aged 18–65 years who were randomized to receive elective gynecological laparoscopic surgery under general anaesthesia with administering PCIA with oliceridine or sufentanil. The primary outcome was the Quality of Recovery - 15 (QoR-15) score on postoperative day 1 (POD 1). Secondary outcome measures comprised: the overall benefit of analgesic score (OBAS) on POD 1; time to first flatus; time to first ambulation; postoperative hospital stay; QoR-15 score on POD 2 and 3; PCIA total injected drugs; the number of patients requiring rescue analgesia and rescue antiemetics; VAS scores from T1 to T6, and MOAA/S scores from T1 to T5; the incidence rate of adverse events; perioperative vital signs. Results: In the primary ITT analysis using multiple imputation (n=136), analysis of covariance adjusting for baseline QoR‑15 score showed that the group O had significantly higher QoR‑15 scores on POD 1 than the group S, with the adjusted mean difference of 11.94 points (95% CI: 10.02–13.86; p < 0.001). Statistical differences between the two groups were observed in POD 1 OBAS score, time to first flatus, time to first ambulation, hospital discharge duration, and QoR-15 scores on POD 2 and 3. In addition, compared with the sufentanil group, the oliceridine group was observed to have a lower incidence of opioid-related adverse events. Conclusion: In this single-center study of relatively young and healthy female patients undergoing gynecologic laparoscopic surgery, oliceridine demonstrated superior recovery quality compared with sufentanil, with a between-group difference exceeding the 6-point MCID threshold. It also significantly accelerated gastrointestinal recovery, shortened hospital stay. Trial Registration: This study was registered with the Chinese Clinical Trial Registry (ChiCTR2400090783).
SN - 1177-8881
ER -