Delayed sequential lung, acral cutaneous and brain metastases after radical nephrectomy for clear cell renal cell carcinoma: a case report
4 affiliations
- 1Bugát Pál Kórház
- 2Mátrai Gyógyintézet
- 3Zala Megyei Szent Rafael Korhaz
- 4Szegedi Tudomanyegyetem
Abstract
Renal cell carcinoma may recur after nephrextomy. Approximately 25-30% of all RCC patients develop metastases, most commonly involving the lungs, bones and brain. Cutaneous metastases are exceptionally rare (about 3% of all RCC patiens) and are associated with a favorable prognosis. While the surgical interventions remain the cornerstone of the management of RCCs, chemotherapy and biological therapies are also available, therefore a complex approach is a must in order to reach the best possible outcome. This is a case report of a 62-year-old male patient with obesity, type 2 diabetes mellitus and smoking history, who underwent a laparoscopic transperitoneal radical right nephrectomy in 2019. Later the histological examination confirmed clear cell renal cell carcinoma. During the course of the disease, he developed multiple metastases involving the lungs, the skin and the brain. He received oncological therapies as well as surgeries – involving robot-assisted thoracoscopic surgery and CyberKnife surgery - and tolerated the therapeutic methods well. This case emphasizes that even small acral lesions in patients with prior renal cell carcinoma may represent metastatic disease and demonstrates the value of prolonged surveillance and multidisciplinary treatment in rare delayed metastatic presentations.
Related
- A Case of Advanced Hepatocellular Carcinoma with Macrovascular Invasion and Lung Metastases Achieving Pathological Complete Remission Following Sequential Multimodal Therapy: A Case Report.
- Widespread Cutaneous Metastases as the Primary Presentation of an Occult Neuroendocrine Tumour of Unknown Primary
- Primary Cutaneous Epithelioid Hemangioendothelioma of the Scalp With Pulmonary, Hepatic, and Osseous Metastases: A Case Report
- Prognostic value of the hemoglobin, albumin, lymphocyte, and platelet score in nonmetastatic renal cell carcinoma after nephrectomy
- Deceased donor interposition graft repair of superior mesenteric artery injury during cytoreductive nephrectomy for metastatic renal cell carcinoma
BibTeX
@article{rajhoczki2026delayed,
title = {{Delayed sequential lung, acral cutaneous and brain metastases after radical nephrectomy for clear cell renal cell carcinoma: a case report}},
author = {Péter Álmos Rajhóczki and Viktor Kardos and Rézan Watti and Marcell Juhász and Magdolna Horváth and Dávid Pócs and Jezdancher Watti},
journal = {Frontiers in Oncology},
year = {2026},
month = oct,
doi = {10.3389/fonc.2026.1817630},
url = {https://www.frontiersin.org/articles/10.3389/fonc.2026.1817630/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Delayed sequential lung, acral cutaneous and brain metastases after radical nephrectomy for clear cell renal cell carcinoma: a case report
AU - Péter Álmos Rajhóczki
AU - Viktor Kardos
AU - Rézan Watti
AU - Marcell Juhász
AU - Magdolna Horváth
AU - Dávid Pócs
AU - Jezdancher Watti
PY - 2026
DA - 2026/10/19
JO - Frontiers in Oncology
DO - 10.3389/fonc.2026.1817630
UR - https://www.frontiersin.org/articles/10.3389/fonc.2026.1817630/full
AB - Renal cell carcinoma may recur after nephrextomy. Approximately 25-30% of all RCC patients develop metastases, most commonly involving the lungs, bones and brain. Cutaneous metastases are exceptionally rare (about 3% of all RCC patiens) and are associated with a favorable prognosis. While the surgical interventions remain the cornerstone of the management of RCCs, chemotherapy and biological therapies are also available, therefore a complex approach is a must in order to reach the best possible outcome. This is a case report of a 62-year-old male patient with obesity, type 2 diabetes mellitus and smoking history, who underwent a laparoscopic transperitoneal radical right nephrectomy in 2019. Later the histological examination confirmed clear cell renal cell carcinoma. During the course of the disease, he developed multiple metastases involving the lungs, the skin and the brain. He received oncological therapies as well as surgeries – involving robot-assisted thoracoscopic surgery and CyberKnife surgery - and tolerated the therapeutic methods well. This case emphasizes that even small acral lesions in patients with prior renal cell carcinoma may represent metastatic disease and demonstrates the value of prolonged surveillance and multidisciplinary treatment in rare delayed metastatic presentations.
SN - 2234-943X
ER -