Acute Kidney Injury Due to Granulomatous Interstitial Nephritis as the Initial Presentation of CLL/SLL Treated with Acalabrutinib
Abstract
Acute kidney injury (AKI) caused by granulomatous interstitial nephritis (GIN) accompanied by chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is extremely rare. A 71-year-old man with severe AKI was diagnosed with CLL/SLL based on bone marrow and lymph node biopsy results. A renal biopsy revealed dense cortical infiltration of CLL/SLL cells and severe interstitial inflammation with granuloma formation, consistent with GIN. Acalabrutinib-Obinutuzumab combination therapy was effective for CLL/SLL, but prednisolone was required to achieve a renal function improvement. A renal biopsy is essential for the diagnosis, and corticosteroids play a key role in managing GIN-associated renal injury, even in the era of targeted therapies.
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BibTeX
@article{shibamiya2026acute,
title = {{Acute Kidney Injury Due to Granulomatous Interstitial Nephritis as the Initial Presentation of CLL/SLL Treated with Acalabrutinib}},
author = {Asuka Shibamiya and Chikako Ohwada and Akane Tanaka and Reiko Watanabe and Jun Ito and Yuichiro Hayashi and Takayuki Shiomi and Chiaki Nakaseko},
journal = {Internal Medicine},
year = {2026},
month = jul,
doi = {10.2169/internalmedicine.7400-26},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7400-26/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Acute Kidney Injury Due to Granulomatous Interstitial Nephritis as the Initial Presentation of CLL/SLL Treated with Acalabrutinib
AU - Asuka Shibamiya
AU - Chikako Ohwada
AU - Akane Tanaka
AU - Reiko Watanabe
AU - Jun Ito
AU - Yuichiro Hayashi
AU - Takayuki Shiomi
AU - Chiaki Nakaseko
PY - 2026
DA - 2026/07/04
JO - Internal Medicine
DO - 10.2169/internalmedicine.7400-26
UR - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7400-26/_article
AB - Acute kidney injury (AKI) caused by granulomatous interstitial nephritis (GIN) accompanied by chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is extremely rare. A 71-year-old man with severe AKI was diagnosed with CLL/SLL based on bone marrow and lymph node biopsy results. A renal biopsy revealed dense cortical infiltration of CLL/SLL cells and severe interstitial inflammation with granuloma formation, consistent with GIN. Acalabrutinib-Obinutuzumab combination therapy was effective for CLL/SLL, but prednisolone was required to achieve a renal function improvement. A renal biopsy is essential for the diagnosis, and corticosteroids play a key role in managing GIN-associated renal injury, even in the era of targeted therapies.
SN - 1349-7235
SN - 0918-2918
ER -