Associations of Serum Cartilage Oligomeric Matrix Protein with Body Composition and Hematological Inflammatory Indices in Postmenopausal Women
5 affiliations
- 1Department of Biochemistry, Poznan University of Physical Education, 61-871 Poznan, Poland
- 2Department of Biomechanics, Poznan University of Physical Education, 61-871 Poznan, Poland
- 3Department and Clinic of Internal Medicine and Metabolic Disorders, Poznan University of Medical Sciences, 61-701 Poznan, Poland
- 4Greater Poland Center of Pulmonology and Thoracic Surgery, 60-569 Poznan, Poland
- 5Department of Swimming and Water Lifesaving, Poznan University of Physical Education, 61-871 Poznan, Poland
Abstract
In the postmenopausal period, a decrease in sex hormone levels may alter body composition and can predispose individuals to increased body fat and musculoskeletal tissue degeneration, including a deterioration in the articular cartilage. The aim of the study was to assess the resting serum cartilage oligomeric matrix protein (COMP) concentrations in postmenopausal women with different body mass indexes (BMIs) and how COMP correlates with both lean and fat mass as well as with blood count-derived inflammatory markers. Thirty-three postmenopausal women were included in the study. Total fat and lean body mass were measured via dual-energy X-ray absorptiometry. Blood serum concentrations of COMP and adiponectin were assessed, and lymphocyte, monocyte and granulocyte counts were determined. The lymphocyte-to-monocyte ratio (LMR) and granulocyte-to-lymphocyte (GLR) ratios were calculated. The analysis of differences in body mass, BMI, lean body mass, fat mass, and android (p ≤ 0.01) and gynoid fat mass (p < 0.05) revealed significantly lower values in the group of women with a normal BMI compared to the group with a BMI above the normal range. In the group of women with a normal BMI, a significant relationship was noted between COMP and lean body mass (p ≤ 0.01). In the group of women with a BMI above the normal range, a significant positive correlation of COMP with LMR (p < 0.05) and a negative correlation with GLR (p < 0.05) were observed. The significant associations between resting serum COMP levels and lean body mass and inflammatory markers, which varied according to BMI categories, suggest that body composition may be an important factor to consider when using COMP for diagnostic purposes.
Related
- Effects of a 12-Week Zumba Training Program on Estimated Aerobic Capacity and Exploratory Hematological and Inflammatory Outcomes in Overweight/Obese Postmenopausal Women: A Pilot Randomized Controlled Trial.
- Inflammatory Hematological Indices in Heart Failure with Preserved Ejection Fraction: Associations with Disease Severity and 12-Month Outcomes
- Peripheral hematological inflammatory signatures in the amyloid-defined Alzheimer’s disease continuum: associations with disease stage, cognitive function, and astroglial activation
- Associations of adiposity and physical fitness with hippocampaldependent mnemonic discrimination in postmenopausal women
- Associations between regional fat distribution and remnant cholesterol in postmenopausal women: a QCT and MRI mDIXON-Quant Study
BibTeX
@article{wojciechowski2026associations,
title = {{Associations of Serum Cartilage Oligomeric Matrix Protein with Body Composition and Hematological Inflammatory Indices in Postmenopausal Women}},
author = {Michał Wojciechowski and Alicja Nowak and Małgorzata Ogurkowska and Tomasz Podgórski and Piotr Leszczyński and Anna Huta-Osiecka and Krystian Wochna},
journal = {International journal of molecular sciences},
year = {2026},
month = oct,
doi = {10.3390/ijms27198831},
url = {https://europepmc.org/article/PMC/PMC13665044},
note = {CC BY},
}
RIS
TY - JOUR
TI - Associations of Serum Cartilage Oligomeric Matrix Protein with Body Composition and Hematological Inflammatory Indices in Postmenopausal Women
AU - Michał Wojciechowski
AU - Alicja Nowak
AU - Małgorzata Ogurkowska
AU - Tomasz Podgórski
AU - Piotr Leszczyński
AU - Anna Huta-Osiecka
AU - Krystian Wochna
PY - 2026
DA - 2026/10/01
JO - International journal of molecular sciences
DO - 10.3390/ijms27198831
UR - https://europepmc.org/article/PMC/PMC13665044
AB - In the postmenopausal period, a decrease in sex hormone levels may alter body composition and can predispose individuals to increased body fat and musculoskeletal tissue degeneration, including a deterioration in the articular cartilage. The aim of the study was to assess the resting serum cartilage oligomeric matrix protein (COMP) concentrations in postmenopausal women with different body mass indexes (BMIs) and how COMP correlates with both lean and fat mass as well as with blood count-derived inflammatory markers. Thirty-three postmenopausal women were included in the study. Total fat and lean body mass were measured via dual-energy X-ray absorptiometry. Blood serum concentrations of COMP and adiponectin were assessed, and lymphocyte, monocyte and granulocyte counts were determined. The lymphocyte-to-monocyte ratio (LMR) and granulocyte-to-lymphocyte (GLR) ratios were calculated. The analysis of differences in body mass, BMI, lean body mass, fat mass, and android (p ≤ 0.01) and gynoid fat mass (p < 0.05) revealed significantly lower values in the group of women with a normal BMI compared to the group with a BMI above the normal range. In the group of women with a normal BMI, a significant relationship was noted between COMP and lean body mass (p ≤ 0.01). In the group of women with a BMI above the normal range, a significant positive correlation of COMP with LMR (p < 0.05) and a negative correlation with GLR (p < 0.05) were observed. The significant associations between resting serum COMP levels and lean body mass and inflammatory markers, which varied according to BMI categories, suggest that body composition may be an important factor to consider when using COMP for diagnostic purposes.
SN - 1422-0067
ER -