Skip to content
DraconiticResearch
Search Sources API
182,549 studies31 sourcesUpdated 32 min ago
Peer-reviewedCC BYInvestigative ophthalmology & visual science

A Review of PRDM13 Transcriptional Regulation in Vertebrate Retinal Development and Disease.

  • Emily R Nettesheim1
  • Katherine J Wert1,2,3,4
4 affiliations
  1. 1Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, United States.
  2. 2Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, United States.
  3. 3Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, Texas, United States.
  4. 4Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States.
Read full textPDFDOICite

Abstract

The retina is a complex neuronal tissue whose development from a common retinal progenitor cell population is tightly controlled by a complex gene regulatory network driven by transcription factors. PRDM13 is a transcription factor known to play a critical role in the specification of neurons across the central nervous system, and its expression is maintained into adulthood in a limited number of neuronal types, including neurons of the dorsomedial hypothalamus and retinal amacrine cells. Dysregulation of PRDM13 has been associated with three inherited human maculopathies - North Carolina macular dystrophy (NCMD), progressive bifocal chorioretinal atrophy (PBCRA), and congenital posterior polar chorioretinal hypoplasia (CPPCRH) - indicating that PRDM13 may also play a role in development and maintenance of non-amacrine retinal cell types. Herein, we review the known roles of PRDM13 across the developing central nervous system to provide a comprehensive understanding of PRDM13's general and tissue-specific functions, as well as how PRDM13 dysregulation may lead to improper macular development and disease. Future studies into PRDM13 and its downstream regulatory network will be important to provide critical insights into the regulation of cell fate decisions in the developing retina.

Related

  1. Single-cell transcriptional dynamics in a living vertebrate
    Elizabeth Eck, Bruno Moretti, Brandon H. Schlomann +13
    Cell SystemsPeer-reviewedLicence not statedFull text16 citedMolecular biology & gene regulationOpenAlex
  2. Beyond DNA—CRISPR technologies for epigenome editing and transcriptional regulation in disease: A scoping review
    Elijah Kolawole Oladipo, Victoria Oluwayemisi Adubiaran, Aanuoluwa Temitayo Iyiola +13
    Clinical and Translational DiscoveryPeer-reviewedCC BYFull textMolecular biology & gene regulationDOAJ
  3. Roles of sialoglycans in vertebrate development
    Herbert Hildebrandt, Anja Münster-Kühnel
    Journal of Biological ChemistryPeer-reviewedCC BY 4.0Molecular biology & gene regulationCrossref
  4. The small ORF (smORF)-encoded polypeptide MIRINE promotes neuronal differentiation in vertebrate brain development
    Y. Kim, B. S. Nilges, A. Elhelbawi +5
    bioRxivPreprintCC BY-NCFull textGeneral biochemistrybioRxiv
  5. cBAF drives AR-V7 expression through regulation of transcriptional termination in castration-resistant prostate cancer
    M. Nakano, S. Uzokboev, J. G. Kirkland +2
    bioRxivPreprintAll rights reservedFull textMolecular biology & gene regulationbioRxiv

Cite

BibTeXRIS
BibTeX
@article{nettesheim2026review,
  title = {{A Review of PRDM13 Transcriptional Regulation in Vertebrate Retinal Development and Disease.}},
  author = {Emily R Nettesheim and Katherine J Wert},
  journal = {Investigative ophthalmology \& visual science},
  year = {2026},
  month = oct,
  doi = {10.1167/iovs.67.12.33},
  url = {https://europepmc.org/article/MED/42885990},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - A Review of PRDM13 Transcriptional Regulation in Vertebrate Retinal Development and Disease.
AU  - Emily R Nettesheim
AU  - Katherine J Wert
PY  - 2026
DA  - 2026/10/01
JO  - Investigative ophthalmology & visual science
DO  - 10.1167/iovs.67.12.33
UR  - https://europepmc.org/article/MED/42885990
AB  - The retina is a complex neuronal tissue whose development from a common retinal progenitor cell population is tightly controlled by a complex gene regulatory network driven by transcription factors. PRDM13 is a transcription factor known to play a critical role in the specification of neurons across the central nervous system, and its expression is maintained into adulthood in a limited number of neuronal types, including neurons of the dorsomedial hypothalamus and retinal amacrine cells. Dysregulation of PRDM13 has been associated with three inherited human maculopathies - North Carolina macular dystrophy (NCMD), progressive bifocal chorioretinal atrophy (PBCRA), and congenital posterior polar chorioretinal hypoplasia (CPPCRH) - indicating that PRDM13 may also play a role in development and maintenance of non-amacrine retinal cell types. Herein, we review the known roles of PRDM13 across the developing central nervous system to provide a comprehensive understanding of PRDM13's general and tissue-specific functions, as well as how PRDM13 dysregulation may lead to improper macular development and disease. Future studies into PRDM13 and its downstream regulatory network will be important to provide critical insights into the regulation of cell fate decisions in the developing retina.
SN  - 0146-0404
SN  - 1552-5783
ER  -