Serum suPAR Associations with Clinical and Laboratory Variables and Emergency Department Disposition in Adults with Respiratory Symptoms: A Prospective Observational Cohort Study
5 affiliations
- 1Laboratory of Human Pathophysiology, Department of Nursing, University of Thessaly, Gaiopolis, 41500 Larissa, Greece
- 2Pulmonology Department, General Hospital of Corfu, 491 00 Corfu, Greece
- 3Laboratory of Respiratory Disorders, Department of Nursing, University of Thessaly, Gaiopolis, 41500 Larissa, Greece
- 4Department of Respiratory Medicine, University of Thessaly, Biopolis, 41110 Larissa, Greece
- 5Public Health and Adults Immunization Laboratory, Department of Nursing, University of Thessaly, Gaiopolis, 41500 Larissa, Greece
Abstract
Background: Soluble urokinase plasminogen activator receptor (suPAR) reflects systemic immune activation. We examined associations between serum suPAR and pulmonary/internal-medicine admission in adults presenting to the emergency department (ED) with respiratory symptoms. Methods: This prospective single-centre exploratory pilot included 87 adults (54 pathway admissions; 33 ED discharges). Serum suPAR concentrations were determined using four-parameter logistic calibration of an eight-point ELISA standard curve, with correction for the fivefold serum dilution. Exploratory adjusted logistic regression and single-marker ROC analyses were performed. Results: Median serum suPAR was 3440.0 (2497.5–4535.0) pg/mL overall, 3955.0 (2979.0–5559.0) pg/mL among admitted patients and 2832.5 (2216.0–3317.5) pg/mL among discharged patients (p < 0.001). The apparent AUC for suPAR was 0.765 (95% bootstrap CI 0.663–0.856). After adjustment for age-category midpoint, sex, SpO2 and log-CRP, the odds ratio for admission per 1-SD increase in log-suPAR was 2.43 (95% CI 1.18–4.98; p = 0.015); the corresponding estimate for log-CRP was 1.69 (0.93–3.07; p = 0.084). Conclusions: Serum suPAR was associated with pathway-specific admission after adjustment for CRP and selected clinical covariates. These exploratory findings do not establish incremental clinical utility and require external validation.
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BibTeX
@article{karpouza2026serum,
title = {{Serum suPAR Associations with Clinical and Laboratory Variables and Emergency Department Disposition in Adults with Respiratory Symptoms: A Prospective Observational Cohort Study}},
author = {Anna Karpouza and Paraskevi Kirgou and Vasiliki Sachtaridou and Dimitrios Papagiannis and Erasmia Rouka and Foteini Malli and Ioannis Pantazopoulos and Ilias Papanikolaou and Ourania S. Kotsiou},
journal = {Journal of Clinical Medicine},
year = {2026},
month = nov,
doi = {10.3390/jcm15228857},
url = {https://www.mdpi.com/2077-0383/15/22/8857},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Serum suPAR Associations with Clinical and Laboratory Variables and Emergency Department Disposition in Adults with Respiratory Symptoms: A Prospective Observational Cohort Study
AU - Anna Karpouza
AU - Paraskevi Kirgou
AU - Vasiliki Sachtaridou
AU - Dimitrios Papagiannis
AU - Erasmia Rouka
AU - Foteini Malli
AU - Ioannis Pantazopoulos
AU - Ilias Papanikolaou
AU - Ourania S. Kotsiou
PY - 2026
DA - 2026/11/12
JO - Journal of Clinical Medicine
DO - 10.3390/jcm15228857
UR - https://www.mdpi.com/2077-0383/15/22/8857
AB - Background: Soluble urokinase plasminogen activator receptor (suPAR) reflects systemic immune activation. We examined associations between serum suPAR and pulmonary/internal-medicine admission in adults presenting to the emergency department (ED) with respiratory symptoms. Methods: This prospective single-centre exploratory pilot included 87 adults (54 pathway admissions; 33 ED discharges). Serum suPAR concentrations were determined using four-parameter logistic calibration of an eight-point ELISA standard curve, with correction for the fivefold serum dilution. Exploratory adjusted logistic regression and single-marker ROC analyses were performed. Results: Median serum suPAR was 3440.0 (2497.5–4535.0) pg/mL overall, 3955.0 (2979.0–5559.0) pg/mL among admitted patients and 2832.5 (2216.0–3317.5) pg/mL among discharged patients (p < 0.001). The apparent AUC for suPAR was 0.765 (95% bootstrap CI 0.663–0.856). After adjustment for age-category midpoint, sex, SpO2 and log-CRP, the odds ratio for admission per 1-SD increase in log-suPAR was 2.43 (95% CI 1.18–4.98; p = 0.015); the corresponding estimate for log-CRP was 1.69 (0.93–3.07; p = 0.084). Conclusions: Serum suPAR was associated with pathway-specific admission after adjustment for CRP and selected clinical covariates. These exploratory findings do not establish incremental clinical utility and require external validation.
SN - 2077-0383
ER -