Radiofrequency Echographic Multi-Spectrometry for bone health assessment in prostate cancer patients receiving Androgen deprivation therapy: A prospective comparative observational study
5 affiliations
- 1Department of Clinical and Experimental Medicine, Foggia University School of Medicine, Viale L. Pinto 1, Foggia, 71121 Italy
- 2Radiology Unit, Mount Sinai Hospital, 600 University Ave, Toronto, ON M5G 1X5 Canada
- 3School of Biomedical Engineering and Imaging Sciences, King’s College London, Strand, London WC2R 2LS, London, UK
- 4Radiology Unit, “Dimiccoli” Hospital, Viale Ippocrate 15, Barletta, 76121 BT Italy
- 5Unit of Urology, L. Bonomo Hospital, ASL BAT, Viale Istria 1, BT 76123 Andria, Italy
Abstract
Background: Androgen deprivation therapy (ADT), used in selected patients with prostate cancer (PCa), is associated with accelerated bone loss and increased fragility fracture risk. Radiofrequency Echographic Multi-Spectrometry (REMS) is a non-ionizing ultrasound-based technique for axial bone mineral density (BMD) assessment.
Aim: To evaluate REMS-derived BMD at the lumbar spine and femoral neck in men with PCa receiving ADT and in age- and body mass index-matched healthy controls.
Methods: In this cross-sectional study, 143 Caucasian men were enrolled between October 2023 and October 2024: 83 patients with histologically confirmed PCa receiving ADT for at least 6 months and 60 healthy controls. REMS scans were performed at the lumbar spine and femoral neck. Between-group differences in BMD, T-score, and Z-score were assessed using an unpaired t-test.
Results: Compared with controls, patients receiving ADT showed lower REMS-derived BMD at the lumbar spine (0.885 ± 0.08 vs. 0.945 ± 0.11 g/cm²; p = 0.007), corresponding to a 6.3% difference. Femoral neck BMD was also lower in the PCa group (0.691 ± 0.08 vs. 0.715 ± 0.10 g/cm²; p = 0.01), corresponding to a 3.4% difference.
Conclusions: These findings are consistent with the known skeletal effects of ADT and support the potential role of REMS as a radiation-free tool for identifying reduced axial BMD in men with PCa undergoing ADT. Longitudinal monitoring assessments are ongoing to clarify the temporal relationship between ADT exposure and progressive bone loss.
Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s40520-026-03467-4.
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BibTeX
@article{montatore2026radiofrequency,
title = {{Radiofrequency Echographic Multi-Spectrometry for bone health assessment in prostate cancer patients receiving Androgen deprivation therapy: A prospective comparative observational study}},
author = {Manuela Montatore and Riccardo Guglielmi and Amanda Isaac and Maria Grazia Capasso and Antonio Corvasce and Federica Masino and Giuseppe Guglielmi},
journal = {Aging Clinical and Experimental Research},
year = {2026},
month = aug,
doi = {10.1007/s40520-026-03467-4},
url = {https://doi.org/10.1007/s40520-026-03467-4},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Radiofrequency Echographic Multi-Spectrometry for bone health assessment in prostate cancer patients receiving Androgen deprivation therapy: A prospective comparative observational study
AU - Manuela Montatore
AU - Riccardo Guglielmi
AU - Amanda Isaac
AU - Maria Grazia Capasso
AU - Antonio Corvasce
AU - Federica Masino
AU - Giuseppe Guglielmi
PY - 2026
DA - 2026/08/04
JO - Aging Clinical and Experimental Research
DO - 10.1007/s40520-026-03467-4
UR - https://doi.org/10.1007/s40520-026-03467-4
AB - Background: Androgen deprivation therapy (ADT), used in selected patients with prostate cancer (PCa), is associated with accelerated bone loss and increased fragility fracture risk. Radiofrequency Echographic Multi-Spectrometry (REMS) is a non-ionizing ultrasound-based technique for axial bone mineral density (BMD) assessment. Aim: To evaluate REMS-derived BMD at the lumbar spine and femoral neck in men with PCa receiving ADT and in age- and body mass index-matched healthy controls. Methods: In this cross-sectional study, 143 Caucasian men were enrolled between October 2023 and October 2024: 83 patients with histologically confirmed PCa receiving ADT for at least 6 months and 60 healthy controls. REMS scans were performed at the lumbar spine and femoral neck. Between-group differences in BMD, T-score, and Z-score were assessed using an unpaired t-test. Results: Compared with controls, patients receiving ADT showed lower REMS-derived BMD at the lumbar spine (0.885 ± 0.08 vs. 0.945 ± 0.11 g/cm²; p = 0.007), corresponding to a 6.3% difference. Femoral neck BMD was also lower in the PCa group (0.691 ± 0.08 vs. 0.715 ± 0.10 g/cm²; p = 0.01), corresponding to a 3.4% difference. Conclusions: These findings are consistent with the known skeletal effects of ADT and support the potential role of REMS as a radiation-free tool for identifying reduced axial BMD in men with PCa undergoing ADT. Longitudinal monitoring assessments are ongoing to clarify the temporal relationship between ADT exposure and progressive bone loss. Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s40520-026-03467-4.
SN - 1594-0667
SN - 1720-8319
ER -